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Perioperative airway and respiratory management for patients with sleep disordered breathing

Research Project

Project/Area Number 24390363
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionChiba University

Principal Investigator

ISONO Shiroh  千葉大学, 医学(系)研究科(研究院), 教授 (80212968)

Research Collaborator ISHIKAWA Teruhiko  
SATO Yumi  
OKAZAKI Junko  
AMEMIYA Megumi  
KATO Shinichiro  
IKEDA Aya  
SATO Shin  
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2012: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywords呼吸 / 上気道閉塞 / 呼吸モニター / 術後合併症 / 咽頭 / 睡眠時呼吸異常 / モニター / 鼻内圧 / 術後呼吸合併症 / flow limitation / 鼻カヌラ
Outline of Final Research Achievements

This study aimed to develop new strategies for perioperative airway and respiratory management for patients with sleep disordered breathing. First, we investigated possibility of using nasal cannula pressure for detecting obstructive disordered breathing as a postoperative respiratory monitor. We found that patterns of the respiratory signals obtained from the nasal cannula during obstructive breaths could be automatically detected and used for development of postoperative respiratory monitor. Second, we tested whether application of negative external pressure to the submental region decreases collapsibility of the passive pharynx in anesthetized subjects. We found that it was effective in non-obese subjects but not in obese subjects. We concluded that the submental negative pressure application could be an alternative treatment for postoperative obstructive events particularly in non-obese subjects who rejected nasal CPAP treatment.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (12 results)

All 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) Patent(Industrial Property Rights) (6 results) (of which Overseas: 6 results)

  • [Journal Article] Submental negative pressure application decreases collapsibility of the passive pharyngeal airway in nonobese women2015

    • Author(s)
      Kato S, Isono S, Amemiya M, Sato S, Ikeda A, Okazaki J, Sato Y, Ishikawa T
    • Journal Title

      J Appl Physiol (1985)

      Volume: 118 Issue: 7 Pages: 912-920

    • DOI

      10.1152/japplphysiol.00158.2014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Pathophysiological considerations of perioperative respiratory managements of obese patients with obstructive sleep apnea2013

    • Author(s)
      Shiroh Isono
    • Journal Title

      Sleep Medicine Clinic

      Volume: 8 Issue: 1 Pages: 59-64

    • DOI

      10.1016/j.jsmc.2012.12.005

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Submental Negative Pressure Application Improves Collapsibility of the Passive Pharyngeal Airway2015

    • Author(s)
      Kato S, Isono S, Amemiya M, Sato S, Ikeda A, Okazaki J, Sato Y, Teruhiko Ishikawa T
    • Organizer
      American Society for Anesthesiologists annual meeting
    • Place of Presentation
      ニューオリンズ(米国)
    • Year and Date
      2015-10-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Submental Negative Pressure Application Improves Collapsibility of the Passive Pharyngeal Airway2015

    • Author(s)
      Kato S, Isono S, Amemiya M, Sato S, Ikeda A, Okazaki J, Sato Y, Teruhiko Ishikawa T
    • Organizer
      Society for Anesthesia and Sleep Medicine
    • Place of Presentation
      ニューオリンズ(米国)
    • Year and Date
      2015-10-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 下顎陰圧負荷(NEP)により気道開通性は改善する2015

    • Author(s)
      加藤 辰一朗, 池田 彩, 雨宮 めぐみ, 佐藤 晋, 石川 輝彦, 磯野 史朗
    • Organizer
      第61回日本麻酔科学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川・横浜)
    • Year and Date
      2015-05-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Does negative pressure applied to the submandible region improve collapsibility of the passive pharyngeal airway?2013

    • Author(s)
      Kato S, Amemiya M, Sato S, Sato Y, Ikeda A, Okazaki J, Ishikawa T, Isono S
    • Organizer
      Society for Anesthesia and Sleep Medicine
    • Place of Presentation
      サンフランシスコ(米国)
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] APPARATUS FOR DETERMINING RESPIRATORY CONDITION2014

    • Inventor(s)
      野中幸夫、磯野史朗、清水剛
    • Industrial Property Rights Holder
      野中幸夫、磯野史朗、清水剛
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-06-26
    • Related Report
      2014 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 呼吸状態判定装置2014

    • Inventor(s)
      野中幸夫、磯野史朗、清水剛
    • Industrial Property Rights Holder
      野中幸夫、磯野史朗、清水剛
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-06-28
    • Related Report
      2014 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 呼吸状態判定装置2014

    • Inventor(s)
      野中幸夫、磯野史朗、清水剛
    • Industrial Property Rights Holder
      野中幸夫、磯野史朗、清水剛
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-06-25
    • Related Report
      2014 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 呼吸状態判定装置2013

    • Inventor(s)
      野中幸夫、磯野史朗、清水剛
    • Industrial Property Rights Holder
      野中幸夫、磯野史朗、清水剛
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-05-24
    • Related Report
      2013 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] Apparatus for determining respiratory condition2013

    • Inventor(s)
      野中幸夫、磯野史朗、清水剛
    • Industrial Property Rights Holder
      野中幸夫、磯野史朗、清水剛
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-05-24
    • Related Report
      2013 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] Apparatus for determining respiratory condition2013

    • Inventor(s)
      野中幸夫、磯野史朗、清水剛
    • Industrial Property Rights Holder
      野中幸夫、磯野史朗、清水剛
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-05-23
    • Related Report
      2013 Annual Research Report
    • Overseas

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Published: 2012-04-24   Modified: 2019-07-29  

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