Does acute pain progress to chronic pain: mechanisms of persistent postoperative pain
| Project/Area Number |
24390365
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Satoshi 信州大学, 学術研究院医学系, 准教授 (60293510)
SUGIYAMA Yuki 信州大学, 学術研究院医学系, 助教 (10468100)
ISHIDA Takashi 信州大学, 医学部附属病院, 助教(診療) (60531952)
SUGIYAMA Daisuke 信州大学, 医学部, 助教(特定雇用) (40467189)
KAWAMATA Tomoyuki 信州大学, 医学部, 准教授 (80336388)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2014: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2013: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2012: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Keywords | 術後痛 / 遷延性術後痛 / 動物モデル / 筋肉 / 慢性炎症 / マイクログリア / 筋挫傷 / 脊髄後角 / 麻酔科学 / 周術期管理学 / 周術期疼痛学 / 急性術後痛 / 慢性痛化 / 皮膚切開 / 筋傷害 / 脊髄 / 急性痛 / 慢性痛 |
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| Outline of Final Research Achievements |
We hypothesized that muscle injury with persistent inflammation would induce persistent postoperative pain (PPOP). We prepared two types of muscle injury, plantar muscle incision and plantar muscle cryoinjury caused by liquid nitrogen of the rat hind paw. Plantar muscle cryoinjury induced greater mechanical hyperalgesia from day 5 to 8 and spontaneous pain from day 3 to 7 compared with plantar muscle incision. In plantar muscle cryoinjury, the number of inflammatory cells in injured muscle and spinal Iba-1 expression were significantly higher compared with those in plantar muscle incision. Taken together, plantar muscle cryoinjury is a more appropriate model of PPSP compared with plantar muscle incision. This model effectively reflected the characteristics of PPSP. In addition, the results of this study suggest that spinal microglial activation is involved in the pathogenic mechanism of PPOP.
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Report
(5 results)
Research Products
(42 results)
