| Budget Amount *help |
¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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| Outline of Final Research Achievements |
Recently, we found that secreted REIC/Dkk-3 protein induces differentiation from monocytes to dendritic cell-like cells. Until now, the anti-cancer effects of REIC/Dkk-3 protein have been also reported. In this study, we identified and purified a 17 kDa cysteine-rich stable product of the REIC/Dkk-3 protein (17kDa REIC/Dkk-3) which shows the protein character of limited degradation. We herein demonstrated that the C17-REIC indicates anti-cancer effects in response to intraperitoneal administration and its effects on the activation of immunocompetent cells in blood.
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