A novel therapeutic strategy for prostate cancer treatment with anti-cancer immunological proteins.
| Project/Area Number |
24390368
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
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| Research Field |
Urology
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|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
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|---|
| Co-Investigator(Kenkyū-buntansha) |
KAKU Haruki 岡山大学, 岡山大学病院, 講師 (60346426)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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|---|
| Keywords | サイトカイン / 癌 / STAT / 癌免疫 / 前立腺癌 / タンパク質 / がん / 免疫学 / REIC/Dkk-3 |
|---|
| Outline of Final Research Achievements |
Recently, we found that secreted REIC/Dkk-3 protein induces differentiation from monocytes to dendritic cell-like cells. Until now, the anti-cancer effects of REIC/Dkk-3 protein have been also reported. In this study, we identified and purified a 17 kDa cysteine-rich stable product of the REIC/Dkk-3 protein (17kDa REIC/Dkk-3) which shows the protein character of limited degradation. We herein demonstrated that the C17-REIC indicates anti-cancer effects in response to intraperitoneal administration and its effects on the activation of immunocompetent cells in blood.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Integrin antagonist augments the therapeutic effect of adenovirus-mediated REIC/Dkk-3 gene therapy for malignant glioma2015
Author(s)
Shimazu Y, Kurozumi K, Ichikawa T, Fujii K, Onishi M, Ishida J, Oka T, Watanabe M, Nasu Y, Kumon H, Date I.
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Journal Title
Gene Ther
Volume: 22
Pages: 146-154
DOI
Related Report
Peer Reviewed
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[Journal Article] Dramatic increase in expression of a transgene by insertion of promoters downstream of the cargo gene2014
Author(s)
Masakiyo Sakaguchi, Masami Watanabe, Rie Kinoshita, Haruki Kaku, Hideo Ueki, Junichiro Futami, Hitoshi Murata, Yusuke Inoue, Shun-Ai Li, Peng Huang, Endy Widya Putranto, I. Made, Winarsa Ruma, Yasutomo Nasu, Hiromi Kumon, Nam-ho Huh
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Journal Title
Mol Biotech
Volume: 56
Pages: 621-630
DOI
Related Report
Peer Reviewed
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[Journal Article] Potential of adenovirus-mediated REIC/Dkk-3 gene therapy for use in the treatment of pancreatic cancer2014
Author(s)
Uchida D, Shiraha H, Kato H, Nagahara T, Iwamuro M, Kataoka J, Horiguchi S, Watanabe M, Takaki A, Nouso K, Nasu Y, Yagi T, Kumon H, Yamamoto K.
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Journal Title
Journal of Gastroenterology and Hepatology
Volume: 29
Pages: 973-983
DOI
NAID
Related Report
Peer Reviewed
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