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A novel device for drug delivery to the posterior segment of the eye

Research Project

Project/Area Number 24390392
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionHokkaido University

Principal Investigator

Ishida Susumu  北海道大学, 医学(系)研究科(研究院), 教授 (10245558)

Co-Investigator(Kenkyū-buntansha) OZAWA Yoko  慶應義塾大学, 医学部, 講師 (90265885)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Keywordsドラッグデリバリーシステム / レニン・アンジオテンシン系 / ドラッグデリバリーシステ ム / レニン・アンジオテンシン / 後眼部失明疾患 / レニン-アンジオテンシン
Outline of Final Research Achievements

We evaluated the safety of conjunctival rings (CR), a novel device for drug delivery to the posterior segment of the eye. Our data demonstrated that CR is safe for use in vivo. The use of CR has the advantage of avoiding several side effects that are associated with the existing implant devices, since removing the device from the ocular surface easily discontinues the drug therapy. Therefore, CR could be a new drug delivery device and safe approach in the treatment of posterior segment diseases such as age-related macular degeneration, diabetic macular edema and uveitis.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (49 results)

All 2016 2015 2014 2013

All Journal Article (30 results) (of which Peer Reviewed: 22 results,  Open Access: 6 results,  Acknowledgement Compliant: 1 results) Presentation (19 results) (of which Int'l Joint Research: 5 results,  Invited: 6 results)

  • [Journal Article] Dong Y, Dong Z, Kase S, Ando R, Fukuhara J, Kinoshita S, Inafuku S, Tagawa Y, Ishizuka ET, Saito W, Murata M, Kanda A, Noda K, Ishida S2016

    • Author(s)
      Phosphorylation of alphaB-crystallin in epiretinal membrane of human proliferative diabetic retinopathy
    • Journal Title

      Int J Ophthalmol

      Volume: -

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of vascular endothelial growth factor-C by tumor necrosis factor-α in the conjunctiva and pterygium2016

    • Author(s)
      Dong Y, Kase S, Dong Z, Fukuhara J, Tagawa Y, Ishizuka ET, Murata M, Shinmei Y, Ohguchi T, Kanda A, Noda K, Ishida S
    • Journal Title

      Int J Mol Med

      Volume: -

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Localization of Acrolein-lysine adduct in fibrovascular tissues of proliferative diabetic retinopathy2016

    • Author(s)
      Dong Y, Noda K, Murata M, Yoshida S, Saito W, Kanda A, Ishida S
    • Journal Title

      Curr Eye Re

      Volume: -

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vitreous levels of vascular endothelial growth factor-B in proliferative diabetic retinopathy2016

    • Author(s)
      Kinoshita S, Noda K, Saito W, Kanda A, Ishida S
    • Journal Title

      Acta Ophthalmol

      Volume: - Issue: 6

    • DOI

      10.1111/aos.12969

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increase of Sialylated N-glycans in Eyes with Neovascular Glaucoma Secondary to Proliferative Diabetic Retinopathy2016

    • Author(s)
      Inafuku S., Noda K., Amano M., Nishimura S-I., Ishida S.
    • Journal Title

      Curr. Eye Res.

      Volume: 印刷中 Pages: 1-4

    • DOI

      10.3109/02713683.2015.1068816

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alteration of N-glycan profiles in Diabetic Retinopathy2015

    • Author(s)
      Inafuku S., Noda K., Amano M., Murata M., Saito W., Ohashi T., Kanda A., Nishimura S-I., Ishida S.
    • Journal Title

      Invest. Ophthalmol. Vis. Sci.

      Volume: 56 Issue: 9 Pages: 5316-5322

    • DOI

      10.1167/iovs.15-16747

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ATP6AP2/(pro)renin receptor contributes to glucose metabolism via stabilizing the pyruvate dehydrogenase E1 b-subunit.2015

    • Author(s)
      Kanda A, Noda K, Ishida S.
    • Journal Title

      J Biol Chem.

      Volume: 290 Issue: 15 Pages: 9690-9700

    • DOI

      10.1074/jbc.m114.626713

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Aflibercept traps galectin-1, an angiogenic factor associated with diabetic retinopathy.2015

    • Author(s)
      Kanda A, Noda K, Saito W, Ishida S
    • Journal Title

      Sci Rep

      Volume: 5 Issue: 1 Pages: 17946-17946

    • DOI

      10.1038/srep17946

    • NAID

      120005690890

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of a Dual Inhibitor of SRPK1 and CK2 that Attenuates Pathological Angiogenesis of Macular Degeneration in Mice.2015

    • Author(s)
      Satoshi Morooka, Mitsuteru Hoshina, Isao Kii, et al.
    • Journal Title

      Molecular Pharmacology

      Volume: 88 Issue: 2 Pages: 316-325

    • DOI

      10.1124/mol.114.097345

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] マウス脈絡膜新生血管モデルにおけるゲニステインの抑制効果2015

    • Author(s)
      木下哲志、野田航介、田川義晃、稲福沙織、董 陽子、福原淳一、董 震宇、安藤 亮、神田敦宏、石田 晋
    • Journal Title

      北海道医学雑誌

      Volume: 90 Pages: 72-72

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 網膜細胞生物学と分子標的療法 – ポストVEGF創薬の時代(巻頭言)2015

    • Author(s)
      石田 晋
    • Journal Title

      日本眼科学会雑誌

      Volume: 119 Pages: 759-760

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 網膜疾患におけるVEGFの生物活性とVEGF阻害薬の特色(総説)2015

    • Author(s)
      石田 晋
    • Journal Title

      日本の眼科

      Volume: 86 Pages: 1088-1094

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 眼科医にとって研究とは何か. 眼科研修へのアドバイス(総説)2015

    • Author(s)
      石田 晋
    • Journal Title

      眼科研修ノート

      Volume: - Pages: 48-51

    • Related Report
      2015 Annual Research Report
  • [Journal Article] メタボエイジング仮説と眼疾患. 眼疾患の診断と治療(総説)2015

    • Author(s)
      石田 晋
    • Journal Title

      眼科研究ノート

      Volume: - Pages: 432-437

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 糖尿病網膜症における炎症と血管新生の分子病態(総説)2015

    • Author(s)
      石田 晋
    • Journal Title

      日本糖尿病学会誌

      Volume: 19 Pages: 56-60

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 現代社会の環境因子からとらえた加齢黄斑変性(総説)2015

    • Author(s)
      神田敦宏、石田 晋
    • Journal Title

      医学のあゆみ

      Volume: 253 Pages: 162-165

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 【感覚とその異常】感覚の基礎知識 視覚(総説)2015

    • Author(s)
      神田敦宏、石田 晋
    • Journal Title

      Clinical Neuroscience

      Volume: 33 Pages: 504-506

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Amelioration of experimental autoimmune uveoretinitis by inhibition of glyceraldehyde derived-advanced glycation end product formation.2014

    • Author(s)
      Dong Z, Iwata D, Kitaichi N, Takeuchi M, Sato M, Endo N, Iwabuchi K, Ando R, Fukuhara J, Kinoshita S, Lennikov A, Kitamura M, Mizuuchi K, Kanda A, Noda K, Namba K, Yamagishi S, Ohno S, Ishida S
    • Journal Title

      J Leukoc Biol

      Volume: 96 Issue: 6 Pages: 1077-1085

    • DOI

      10.1189/jlb.3a0513-288rrr

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of the receptor-associated prorenin system in the pathogenesis of human conjunctival lymphoma.2014

    • Author(s)
      Ishizuka ET, Kanda A, Kase S, Noda K, Ishida S
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 56 Issue: 1 Pages: 74-80

    • DOI

      10.1167/iovs.14-15743

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aqueous humor levels of placental growth factor in diabetic retinopathy.2014

    • Author(s)
      Ando R, Noda K, Namba S, Saito W, Kanda A, Ishida S.
    • Journal Title

      Acta Ophthalmol.

      Volume: Epub

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of alphaB-crystallin and vascular endothelial growth factor in conjunctival squamous cell carcinoma.2013

    • Author(s)
      Dong Z, Kase S, Ando R, Fukuhara J, Kinoshita S, Dong Y, Takashina S, Kanda A, Noda M, Noda K, Ishida S.
    • Journal Title

      Anticancer Res.

      Volume: 33 Pages: 3745-3751

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Specific inhibition of serine/arginine-rich protein kinase attenuates choroidal neovascularization.2013

    • Author(s)
      Dong Z, Noda K, Kanda A, Fukuhara J, Ando R, Murata M, Saito W, Hagiwara M, Ishida S.
    • Journal Title

      Mol Vis.

      Volume: 19 Pages: 536-543

    • NAID

      120005372289

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of vascular endothelial growth factor C in human pterygium.2013

    • Author(s)
      Fukuhara J, Kase S, Ohashi T, Ando R, Dong Z, Noda K, Ohguchi T, Kanda A, Ishida S.
    • Journal Title

      Histochem Cell Biol.

      Volume: 139 Pages: 381-389

    • NAID

      120005228265

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tissue kallikrein attenuates choroidal neovascularization via cleavage of vascular endothelial growth factor.2013

    • Author(s)
      Fukuhara J, Noda K, Murata M, Namba S, Kinoshita S, Dong Z, Ando R, Lennikov A, Kanda A, Ishida S.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 54 Pages: 274-279

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vitreous renin-angiotensin system is mediated by soluble (pro)renin receptor in diabetic retinopathy: New implication of receptor-associated prorenin system.2013

    • Author(s)
      Kanda A, Ishida S.
    • Journal Title

      Twn J Ophthalmol.

      Volume: 3 Pages: 51-53

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vitreous renin activity correlates with vascular endothelial growth factor in proliferative diabetic retinopathy2013

    • Author(s)
      Kanda A, Noda K, Saito W, Ishida S.
    • Journal Title

      Br J Ophthalmol.

      Volume: 97 Pages: 666-668

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Atp6ap2/(pro)renin receptor interacts with Par3 as a cell polarity determinant required for laminar formation during retinal development in mice.2013

    • Author(s)
      Kanda A, Noda K, Yuki K, Ozawa Y, Furukawa T, Ichihara A, Ishida S.
    • Journal Title

      J Neurosci.

      Volume: 33 Pages: 19341-19351

    • NAID

      120005438252

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of vascular endothelial growth factor in eyes with Coats disease.2013

    • Author(s)
      Kase S, Rao NA, Yoshikawa H, Fukuhara J, Noda K, Kanda A, Ishida S.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 54 Pages: 57-62

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of chronic inflammation in diabetic retinopathy.2013

    • Author(s)
      Noda K, Ishida S.
    • Journal Title

      Inflamm Regen

      Volume: 33 Pages: 230-237

    • NAID

      130004482313

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of 2% rebapimide ophthalmic solution on the tear functions and ocular surface of the superoxide dismutase-1 (Sod1) knockout mice.2013

    • Author(s)
      Ohguchi T, Kojima T, Ibrahim OM, Nagata T, Shimizu T, Shirasawa T, Kawakita T, Satake Y, Tsubota K, Shimazaki J, Ishida S.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 54 Pages: 7793-7802

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Afilibercept traps Galectin-1, an angiogenic factor associated with diabetic retinopathy2016

    • Author(s)
      Ishida S
    • Organizer
      39th Annual Macula Society Meeting
    • Place of Presentation
      Florida(USA)
    • Year and Date
      2016-02-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 受容体結合プロレニン系とミトコンドリア活性酵素2015

    • Author(s)
      石田 晋
    • Organizer
      平成27年度慶大眼科オータムセミナー
    • Place of Presentation
      京王プラザホテル(東京都・新宿区)
    • Year and Date
      2015-11-01
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Receptor-associated prorenin system in diabetic retinopathy. Ocular inflammation and diabetic retinopathy: The unplanned marriage.2015

    • Author(s)
      Ishida S
    • Organizer
      13th International Ocular Inflammation Society (IOIS) Congress
    • Place of Presentation
      San Francisco(USA)
    • Year and Date
      2015-09-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 糖尿病網膜症の硝子体および血漿におけるN型糖鎖プロファイル2015

    • Author(s)
      稲福沙織、野田航介、天野麻穂、大橋 哲、齋藤 航、村田美幸、神田敦宏、西村紳一郎、石田 晋
    • Organizer
      第36回日本炎症・再生医学会
    • Place of Presentation
      虎ノ門フィルズフォーラム(東京都・港区)
    • Year and Date
      2015-07-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 結膜リンパ腫における受容体結合プロレニン系の病態への関与2015

    • Author(s)
      石塚タンエルダル、神田敦宏、加瀬 諭、野田航介、石田 晋
    • Organizer
      第36回日本炎症・再生医学会
    • Place of Presentation
      虎ノ門フィルズフォーラム(東京都・港区)
    • Year and Date
      2015-07-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 毒性終末糖化産物阻害薬による自己免疫性ぶどう膜網膜炎の軽症化2015

    • Author(s)
      董 震宇、北市伸義、野田航介、竹内正義、石田 晋
    • Organizer
      第36回日本炎症・再生医学会
    • Place of Presentation
      虎ノ門フィルズフォーラム(東京都・港区)
    • Year and Date
      2015-07-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] VEGF阻害薬の理論と糖尿病黄斑浮腫に対する実践2015

    • Author(s)
      石田 晋
    • Organizer
      横浜糖尿病合併症治療フォーラム
    • Place of Presentation
      横浜ベイホテル東急(神奈川県・横浜市)
    • Year and Date
      2015-06-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] VEGF阻害薬の基礎と糖尿病黄斑浮腫に対する効果2015

    • Author(s)
      石田 晋
    • Organizer
      第85回九州眼科学会 ・平成27年度九州ブロック眼科講習会
    • Place of Presentation
      鹿児島県医師会館(鹿児島県・鹿児島市)
    • Year and Date
      2015-05-31
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Alteration of N-glycan profiles in diabetic retinopathy2015

    • Author(s)
      Inafuku S, Noda K, Amano M, Murata M, Saito W, Ohashi T, Kanda A, Nishimura S, Ishida S.
    • Organizer
      Association for Research in Vision and Ophthalmology Annual Meeting
    • Place of Presentation
      Denver(USA)
    • Year and Date
      2015-05-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Role of the receptor associated prorenin system in trabecular meshwork of glaucoma2015

    • Author(s)
      Ishizuka ET, Kanda A, Shinmei Y, Dong Y, Inafuku S, Tagawa Y, Noda K, Ishida S
    • Organizer
      Association for Research in Vision and Ophthalmology Annual Meeting
    • Place of Presentation
      Denver(USA)
    • Year and Date
      2015-05-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Rebamipide reduces the response to capsaicin in sensory ganglion cells2015

    • Author(s)
      Tagawa Y, Noda K, Miyamoto R, Otsuguro K, Ishizuka ET, Inafuku S, Ohguchi T, Kanda A,    Ishida S
    • Organizer
      ARVO (Association for Research in Vision and Ophthalmology) Annual Meeting
    • Place of Presentation
      Denver(USA)
    • Year and Date
      2015-05-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] VEGF阻害薬の薬剤特性 -アイソフォーム選択性の意義-. モーニングセミナー「VEGF165阻害薬マクジェン最新情報 エキスパートはこう使う!」.2015

    • Author(s)
      石田 晋
    • Organizer
      第119回 日本眼科学会総会
    • Place of Presentation
      ロイトン札幌(北海道・札幌市)
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 糖尿病網膜症の硝子体および血漿におけるΝ型糖鎖の網羅的解析.学術展示優秀賞受賞講演2015

    • Author(s)
      稲福沙織、野田航介、天野麻穂、大橋 哲、齋藤 航、村田美幸、神田敦宏、西村紳一郎、石田 晋
    • Organizer
      第119回 日本眼科学会総会
    • Place of Presentation
      ロイトン札幌(北海道・札幌市)
    • Year and Date
      2015-04-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 結膜節外辺縁帯B細胞性リンパ腫におけるレニン・アンジオテンシン系の病態への関与2015

    • Author(s)
      石塚タンエルダル、神田敦宏、加瀬 諭、安藤 亮、董 陽子、稲福沙織、田川義晃、野田航介、石田 晋
    • Organizer
      第119回日本眼科学会総会
    • Place of Presentation
      ロイトン札幌(北海道・札幌市)
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 糖負荷刺激によるシアル酸転移酵素の誘導2015

    • Author(s)
      稲福沙織、野田航介、天野麻穂、大橋 哲、齋藤 航、村田美幸、神田敦宏、西村紳一郎、石田 晋
    • Organizer
      第119回日本眼科学会総会
    • Place of Presentation
      ロイトン札幌(北海道・札幌市)
    • Year and Date
      2015-04-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Evaluation of safety and tolerability of conjunctival ring2015

    • Author(s)
      Kinoshita S, Noda K, Atsumi I, Obata H, Matsunaga T, Ohguchi T, Kanda A, Ishida S
    • Organizer
      Asia-ARVO2015
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-02-16 – 2015-02-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] BUT短縮型ドライアイの寒冷刺激によるシルマー試験の検討2014

    • Author(s)
      田川義晃、大口剛司、野田航介、岩田大樹、水内一臣、田川義継、石田 晋
    • Organizer
      第68回日本臨床眼科学会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県神戸市)
    • Year and Date
      2014-11-13 – 2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Safety evaluation of novel drug delivery device, the conjunctival ring2014

    • Author(s)
      Kinoshita S, Noda K, Takashina S, Dong Y, Atsumi I, Obata H, Matsunaga T, Ohguchi T, Kanda A, Ishida S
    • Organizer
      ARVO
    • Place of Presentation
      Florida( USA)
    • Year and Date
      2014-05-04 – 2014-05-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒト結膜リングのオキュラーサーフェスにおける安全性の検討2014

    • Author(s)
      大口剛司、野田航介、木下哲志、神田敦宏、安枝真一、福島 努、石田 晋
    • Organizer
      第118回日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2014-04-02 – 2014-04-06
    • Related Report
      2014 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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