| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
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| Outline of Final Research Achievements |
We examined whether live imaging for optic nerve axonal flow was useful for predicting the progression of glaucoma optic neuropathy. Our experiments using transgenic mice revealed the movement of mitochondria in the axons of retinal ganglion cells anterogradely and retrogradely. In glaucoma axons, the number of mitochondrial transport was decreased; mitochondria-free axonal regions were increased; mitochondrial sizes were shortened. In aged axons, the number of mitochondrial transport was unchanged; mitochondria-free axonal regions were increased; mitochondrial sizes were shortened. The aged glaucoma axons showed more decreased number of mitochondrial transport than the young glaucoma axons did. These results are the first data about live imaging of axonal transport in a physiologic condition, demonstrating the deterioration of axonal transport before glaucoma optic neuropathy.
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