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New diagnostic strategy for glaucoma optic neuropathy using the visualization for mitochondrial transport in the optic nerve

Research Project

Project/Area Number 24390395
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionUniversity of Fukui

Principal Investigator

Inatani Masaru  福井大学, 医学部, 教授 (40335245)

Co-Investigator(Kenkyū-buntansha) TAKAMURA Yoshihiro  福井大学, 医学部, 准教授 (00283193)
TOMOMATSU Takeshi  福井大学, 医学部附属病院, 助教 (10401994)
TANIHARA Hidenobu  熊本大学, 大学院生命科学研究部(医), 教授 (60217148)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Keywords軸索流 / ミトコンドリア / 緑内障 / 二光子レーザー顕微鏡 / 網膜 / 視神経 / 神経科学 / 軸索
Outline of Final Research Achievements

We examined whether live imaging for optic nerve axonal flow was useful for predicting the progression of glaucoma optic neuropathy. Our experiments using transgenic mice revealed the movement of mitochondria in the axons of retinal ganglion cells anterogradely and retrogradely. In glaucoma axons, the number of mitochondrial transport was decreased; mitochondria-free axonal regions were increased; mitochondrial sizes were shortened. In aged axons, the number of mitochondrial transport was unchanged; mitochondria-free axonal regions were increased; mitochondrial sizes were shortened. The aged glaucoma axons showed more decreased number of mitochondrial transport than the young glaucoma axons did. These results are the first data about live imaging of axonal transport in a physiologic condition, demonstrating the deterioration of axonal transport before glaucoma optic neuropathy.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (24 results)

All 2016 2015 2013 2012 Other

All Int'l Joint Research (1 results) Journal Article (13 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 13 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (5 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results) Remarks (5 results)

  • [Int'l Joint Research] カリフォルニア大学サンディエゴ校(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] In vivo imaging of mitochondrial axonal transport in the diseased and aged mammalian CNS2015

    • Author(s)
      Takihara et al.
    • Journal Title

      Proceedings of the National Academy of Sciences of the U.S.A.

      Volume: 112 Issue: 33 Pages: 10515-10520

    • DOI

      10.1073/pnas.1509879112

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Altered Transport Velocity of Axonal Mitochondria in Retinal Ganglion Cells After Laser-Induced Axonal Injury In Vitro.2015

    • Author(s)
      Yokota S, Takihara Y, Arimura S, Miyake S, Takamura Y, Yoshimura N, Inatani M.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 56 Issue: 13 Pages: 8019-8025

    • DOI

      10.1167/iovs.15-17876

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vitreous and Aqueous Concentrations of Brimonidine Following Topical Application of Brimonidine Tartrate 0.1% Ophthalmic Solution in Humans.2015

    • Author(s)
      Takamura Y
    • Journal Title

      Journal of Ocular Pharmacology and Therapeutics

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.2015

    • Author(s)
      Aung T
    • Journal Title

      Nature Genetics

      Volume: 47 Issue: 4 Pages: 387-392

    • DOI

      10.1038/ng.3226

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Determinants of anterior chamber angle narrowing after mydriasis in the patients with cataract.2015

    • Author(s)
      Arimura S
    • Journal Title

      Graefes Archives Clinical Experimental Ophthalmology

      Volume: 253 Issue: 2 Pages: 307-312

    • DOI

      10.1007/s00417-014-2817-x

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Japanese Phaco-Goniosynechialysis Multicenter Study Group. Long-term efficacy of goniosynechialysis combined with phacoemulsification for primary angle closure2013

    • Author(s)
      Kameda T, Inoue T, Inatani M, Tanihara H
    • Journal Title

      Graefe's Archive for Clinical and Experimental Ophthalmology

      Volume: 251 Issue: 3 Pages: 825-830

    • DOI

      10.1007/s00417-012-2091-8

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aldose reductase inhibitor counteracts the enhanced expression of matrix metalloprotease-10 and improves corneal wound healing in galactose-fed rats.2013

    • Author(s)
      Takamura Y
    • Journal Title

      Molecular Vision

      Volume: 19 Pages: 2477-2486

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human glutathione S-transferase A (GSTA) family genes are regulated by steroidogenic factor 1 (SF-1) and are involved in steroidogenesis.2013

    • Author(s)
      Matsumura T, Imamichi Y, Mizutani T, Ju Y, Yazawa T, Kawabe S, Kanno M, Ayabe T, Katsumata N, Fukami M, Inatani M, Akagi Y, Umezawa A, Ogata T, Miyamoto K
    • Journal Title

      FASEB J

      Volume: 27 Issue: 8 Pages: 3198-3208

    • DOI

      10.1096/fj.12-222745

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anterior capsular contraction and flare intensity in the early stages after cataract surgery in eyes with diabetic retinopathy.2013

    • Author(s)
      Takamura Y
    • Journal Title

      Journal of Cataract & Refractive Surgery

      Volume: 39 Issue: 5 Pages: 716-721

    • DOI

      10.1016/j.jcrs.2012.12.029

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A prospective comparison between trabeculectomy with mitomycin C and phacotrabeculectomy with mitomycin C2013

    • Author(s)
      Ogata-Iwao M, Inatani M, Takihara Y, Inoue T, Iwao K, Tanihara H
    • Journal Title

      Acta Ophthalmologica

      Volume: 91 Issue: 6 Pages: 500-501

    • DOI

      10.1111/aos.12133

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of Rho-associated protein kinase inhibitor on monkey Schlemm's canal endothelial cells2012

    • Author(s)
      Kameda T, Inoue T, Inatani M, 9人3番目
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 53 Issue: 6 Pages: 3092-3103

    • DOI

      10.1167/iovs.11-8018

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elevated levels of monocyte chemoattractant protein-1 in the aqueous humor after phacoemulsification.2012

    • Author(s)
      Kawai M
    • Journal Title

      Investigative Ophthalmology and Visual Science

      Volume: 53 Issue: 13 Pages: 7951-7960

    • DOI

      10.1167/iovs.12-10231

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous increases in multiple proinflammatory cytokines in the aqueous humor of pseudophakic glaucomatous eyes2012

    • Author(s)
      Inoue T, Kawaji T, Inatani M, Kameda T, Yoshimura N, Tanihara H
    • Journal Title

      Journal of Cataract and Refractive Surgery

      Volume: 38 Issue: 8 Pages: 1389-1397

    • DOI

      10.1016/j.jcrs.2012.04.028

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] In vivo imaging of mitochondrial axonal transport in the deseased and aged mammalian CNS.2016

    • Author(s)
      Inatani M
    • Organizer
      The 31th APAO Congress
    • Place of Presentation
      台湾、台北市、コンベンションセンター
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Visualization for axonal damage in glaucoma.2015

    • Author(s)
      Inatani M
    • Organizer
      SNEC 25th anniversary international meeting
    • Place of Presentation
      シンガポール、シンガポール、コンベンションセンター
    • Year and Date
      2015-05-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular mechanism of axonal damage in glaucoma.2015

    • Author(s)
      Inatani M, Yokota S, Takihara Y
    • Organizer
      Asia-ARVO 2015
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-02-16 – 2015-02-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Dynamic imaging of axonal transport in retinal ganglion cells.2013

    • Author(s)
      Inatani M
    • Organizer
      The 28<th> APAO Congress
    • Place of Presentation
      ハイデラバード国際会議場(インド)(招待講演)
    • Year and Date
      2013-01-18
    • Related Report
      2012 Annual Research Report
  • [Presentation] In vivo imaging of mitochondrial axonal transport in the diseased and aged mammalian CNS.2013

    • Author(s)
      Takihara Y
    • Organizer
      The Annual Meeting of the Association for Research in Vision and Ophthalmology
    • Place of Presentation
      Seattle, Washington, USA
    • Related Report
      2013 Annual Research Report
  • [Remarks] 福井大学眼科学教室

    • URL

      http://ganka-fukuimed.jp

    • Related Report
      2015 Annual Research Report
  • [Remarks] 福井大学医学部眼科学教室研究内容紹介

    • URL

      http://ganka-fukuimed.jp/class/pages/kenkyu.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 福井大学医学部眼科学教室研究業績

    • URL

      http://ganka-fukuimed.jp/class/pages/gyouseki.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 福井大学医学部眼科学教室研究内容紹介

    • URL

      http://ganka-fukuimed.jp/class/pages/kenkyu.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 福井大学医学部眼科学教室研究業績

    • URL

      http://ganka-fukuimed.jp/class/pages/gyouseki.html

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2012-04-24   Modified: 2022-01-27  

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