Study of biology and regulation of vitreous body
| Project/Area Number |
24390396
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kagoshima University |
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Principal Investigator |
SAKAMOTO Taiji 鹿児島大学, 医歯学総合研究科, 教授 (10235179)
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| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Ikuro 鹿児島大学, 医歯学総合研究科, 教授 (20082282)
HASHIGUCHI Teruto 鹿児島大学, 医歯学総合研究科, 教授 (70250917)
TAKAO Sonshin 鹿児島大学, 学内共同利用施設等 (80171411)
KOSAI Kenichirou 鹿児島大学, 医歯学総合研究科, 教授 (90258418)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Keywords | 硝子体 / ヒアルロン酸 / 細胞破壊物 / 炎症 / 硝子体手術 / histone / DAMPs / retina / vitreous body / degradome / hyaluronan / cell reaction / 網膜剥離 / デグラドーム / ヒストン / アポトーシス / 糖尿病網膜症 / 加齢黄斑変性 |
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| Outline of Final Research Achievements |
Biology of vitreous body was investigated during the study period. First, molecular profile of vitreous body was evaluated by measuring such molecules as HMGB-1 and histone H3. The results showed that both were rich in the vitreous with retinal detachment. The co-incubation of HMGB-1 and histone H3 with retinal cells increased the production of inflammatory cytokines by these cells. Furthermore, the apoptosis was induced when added excessively. These indicated that the damage in retinal disease does not only cause functional impairment of the damaged retina, but also induces collateral damage to the surrounding retina. To prevent this complication, we found that hyaluronic acid was most effective, which lead to development of novel surgical method termed “soft shell vitrectomy”. In each project, the detailed cellular mechanisms such as involvement of toll-like receptors were also studied.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Ultrastructural Changes of the Vitreoretinal Interface During Long-Term Follow-up After Removal of the Internal Limiting Membrane.2014
Author(s)
Hisatomi T, Notomi S, Tachibana T, Sassa Y, Ikeda Y, Nakamura T, Ueno A, Enaida H, Murata T, Sakamoto T, Ishibashi T
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Journal Title
Am J Ophthalmol.
Volume: 158
Pages: 550-556
DOI
Related Report
Peer Reviewed
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[Journal Article] Individualized, spectral domain-optical coherence tomography-guided facedown posturing after macular hole surgery: minimizing treatment burden and maximizing outcome.2014
Author(s)
Yamashita T, Sakamoto T, Yamashita T, Sonoda S, Yamakiri K,Otsuka H, Hisatomi T, Imaki H, Ishibashi T, Dugel PU
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Journal Title
Invest Ophthalmol Vis Sci.
Volume: 34
Pages: 1367-1375
DOI
Related Report
Peer Reviewed
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