| Project/Area Number |
24390403
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Sawa Teiji 京都府立医科大学, 医学(系)研究科(研究院), 教授 (10206013)
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| Co-Investigator(Kenkyū-buntansha) |
Moriyama Kiyoshi 杏林大学, 医学部, 准教授 (10296717)
Ueno Hiroshi 京都府立医科大学, 医学(系)研究科, 講師 (20381965)
Kurahashi Kiyoyasu 横浜市立大学, 大学病院, 准教授 (50234539)
Amaya Fumimasa 京都府立医科大学, 医学(系)研究科, 准教授 (60347466)
Hashimoto Soshi 京都府立医科大学, 医学(系)研究科, 客員講師 (60515279)
Matsuyama Hiroki 京都府立医科大学, 医学(系)研究科, 客員講師 (80515289)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | グラム陰性菌 / V抗原 / 血清抗体価 / 三型分泌システム / 感染 / 免疫 / PcrV / LcrV / 重症肺炎 / 緑膿菌 / 3型分泌システム / 敗血症 / 抗体価 / 肺炎 / III型分泌システム / ワクチン / 血清疫学調査 |
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| Outline of Final Research Achievements |
We made the following five recombinant V-antigen proteins of pathogenic gram-negative bacteria (Pseudomonas aeruginosa PcrV, Yersinia LcrV, Vibrio VcrV, Aeromonas AcrV, and Photolahbdus LssV). Then, we developed measurement system for human anti-V-antigen titers, and performed an epidemiological study to examine serum titers against these V-antigens in 200 volunteers. As a result, we found that there are wide variations in V-antigen titers and these variations may have some effects on the infectivity of individuals.
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