| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Outline of Final Research Achievements |
Signaling linked to αklotho/FGF23 is predominantly found in the proximal renal tubules, where it inhibits Pi reabsorption and 1α-hydroxylase activity. Therefore disrupted function of FGF23/αklotho in kl/kl mice and αklotho-deficient (αklotho-/-) mice results in hyperphosphatemia and hypercalcemia. Despite of elevated concentration of serum Pi, bone minerals around several osteocytes were disappeared. Kl/kl mice fed with low Pi diet showed improved bone matrix, but, αklotho-/- mice still demonstrated patched unmineralized areas in the periphery of the osteocytes. In the kidney of kl/kl mice fed with low Pi diet showed increased expression of αklotho. Therefore, it seems likely that improved histology in bone in kl/kl mice may be due to increased expression of αklotho, but not normalized concentration of serum Pi.
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