New paradigm of enamel maturation: Mechanisms of non-endocytotic resorption and degradation of enamel matrix proteins
| Project/Area Number |
24390408
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TAKANO Yoshiro 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (90126425)
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| Co-Investigator(Kenkyū-buntansha) |
TABATA J Makoto 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (20243248)
馬場 麻人 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (90251545)
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| Research Collaborator |
ISEKI Hachiro
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
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| Keywords | emamel matrix / amelogenin / proteasome / ubiquitin / endocytosis / ameloblast / enamel matrix / エナメル質 / 口腔解剖学 / 硬組織 |
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| Outline of Final Research Achievements |
Massive removal of organic matrix components from immature enamel is essential for the induction of large apatite crystals and ultimately high mineralization of the unique dental tissue of epithelial origin.
Amelogenesis is characterized by degradation and re-absorption of enamel matrix proteins in both secretory and maturation stages of amelogenesis but how exactly the ameloblasts remove organic constituents is not well documented. Current study confirmed existence of organic anion transporters (OATs) in the Tomes’ process and ruffled border membranes of ameloblasts and that ameloblasts transport the cleavage product of enamel matrix proteins via OATs to the cytosol for final processing through the ubiquitin-proteasome system.
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Report
(4 results)
Research Products
(34 results)
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[Presentation] Rearing Medaka Fish in International Space Station (ISS) for Bone Metabolism Study2014
Author(s)
Masahiro Chatani, Akiko Mantoku, Kazuhiro Takeyama, Kazuhiro Aoki, Yasutaka Sugamori, Keiichi Ohya, Satoko Uchida, Hiromi Suzuki, Toru Sakimura, Yasushi Kono, Fumiaki Tanigaki, Masaki Shirakawa, Keiji Inohaya, Dawud Abduweri, Yoshiro Takano, Akira Kudo
Organizer
ASBMR
Place of Presentation
Houston, USA
Year and Date
2014-09-12 – 2014-09-15
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[Presentation] Alveolar bone loss induced by hypofunctional tooth movement in rats.2013
Author(s)
Chisa Shitano, Otto Baba, Sawa Kaneko, Jun Hosomichi, Yasuhiro Shimizu, Naoki Shibutani, Risa Usumi-Fujita, Yoshiro Takano, Takashi Ono
Organizer
IADR-APR, JADR General Session 2013
Place of Presentation
Bangkok, Thailand
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