| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Outline of Final Research Achievements |
Evasion of the human immune system is a hallmark of pathogenic streptococci that cause invasive infections, and leads to exacerbation of pathological condition during the course of infection. In this study, we revealed that a group A streptococcal protease, SpeB, cleaves C1 esterase inhibitor, and the cleavage is attributable to bacterial survival and aberration of complement system. Moreover, we demonstrate a mechanism by which streptococcus species frequently isolated from subacute bacterial endocarditis evades neutrophil killing.
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