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Reglation of mineralization by osteocyte

Research Project

Project/Area Number 24390412
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Functional basic dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

NAKAHSIMA Tomoki  東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (00346959)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Keywords骨代謝学 / 骨細胞 / ミネラリゼーション / 骨溶解
Outline of Final Research Achievements

Bone is constantly renewed by the balanced action of osteoblastic bone formation and osteoclastic bone resorption both of which mainly occur at the bone surface. This restructuring process called "bone remodeling" is important not only for normal bone mass and strength, but also for mineral homeostasis. Osteocytes, the most numerous and least well studied bone cells, are stellate-shaped cells enclosed within the bone lacuno-canalicular network of bone. Based on the osteocyte location within the bone matrix and the cellular morphology, it is proposed that osteocytes potentially contribute to the regulation of bone remodeling in response to mechanical and endocrine stimuli. To identify the regulation factor of bone remodeling and mineralization, we performed a genome-wide screening of osteocytes, and in vivo analysis of bone disease model and gene targeting mice.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (34 results)

All 2015 2014 2013 2012 Other

All Journal Article (18 results) (of which Peer Reviewed: 8 results,  Acknowledgement Compliant: 1 results,  Open Access: 2 results) Presentation (15 results) (of which Invited: 6 results) Book (1 results)

  • [Journal Article] Global epigenomic analysis indicates protocadherin-7 activates osteoclastogenesis by promoting cell-cell fusion2014

    • Author(s)
      Nakamura H, Nakashima T, Hayashi M, Izawa N, Yasui T, Aburatani H, Tanaka S, Takayanagi H.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 455 Issue: 3-4 Pages: 305

    • DOI

      10.1016/j.bbrc.2014.11.009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Peyer's patches and mesenteric lymph nodes cooperatively promote enteropathy in a mouse model of food allergy.2014

    • Author(s)
      Nakajima-Adachi, H., Kikuchi, A., Fujimura, Y., Shibahara, K., Makino, T., Goseki-Sone, M., Kihara-Fujioka, M., Nochi, T., Kurashima, Y., Igarashi, O., Yamamoto, M., Kunisawa, J., Toda, M., Kaminogawa, S., Sato, R., Kiyono, H., and Hachimura, S.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 9 Pages: 108294-108294

    • DOI

      10.1371/journal.pone.0108294

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis.2014

    • Author(s)
      Komatsu, N., Okamoto, K., Sawa, S., Nakashima, T., Oh-hora, M., Kodama, T., Tanaka, S., Bluestone, JA. and Takayanagi, H.
    • Journal Title

      Nature Medicine

      Volume: 20 Issue: 1 Pages: 62-68

    • DOI

      10.1038/nm.3432

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] RANKLの多彩な作用2014

    • Author(s)
      中島友紀
    • Journal Title

      実験医学(増刊)

      Volume: 32 Pages: 43-52

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 骨細胞による骨制御2014

    • Author(s)
      中島友紀
    • Journal Title

      腎と骨代謝

      Volume: 27 Pages: 136-146

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 乳癌の骨転移病変とRANKL2014

    • Author(s)
      中島友紀
    • Journal Title

      腎と骨代謝

      Volume: 27 Pages: 15-23

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Osteocyte control of osteoclastogenesis.2013

    • Author(s)
      O'Brien CA, Nakashima T, Takayanagi H.
    • Journal Title

      Bone

      Volume: 54 Issue: 2 Pages: 258-263

    • DOI

      10.1016/j.bone.2012.08.121

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ストレスと骨の細胞間コミュニケーション2013

    • Author(s)
      中島友紀
    • Journal Title

      CLINICAL CALCIUM

      Volume: 23 Pages: 1595-1603

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 骨細胞による骨吸収制御2013

    • Author(s)
      中島友紀
    • Journal Title

      THE BONE

      Volume: 27 Pages: 49-57

    • Related Report
      2013 Annual Research Report
  • [Journal Article] New insights into osteoclastogenic signaling mechanisms2012

    • Author(s)
      Nakashima T et.ai.
    • Journal Title

      Trends Endocrinol Metab

      Volume: 23 Issue: 11 Pages: 582-590

    • DOI

      10.1016/j.tem.2012.05.005

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteoprotection by semaphorin 3A2012

    • Author(s)
      Mikihito Hayashi, Tomoki Nakashima, Masahiko Taniguchi, Tatsuhiko Kodama, Atsushi Kumanogoh and Hiroshi Takayanagi
    • Journal Title

      Nature

      Volume: 485 Issue: 7396 Pages: 69-74

    • DOI

      10.1038/nature11000

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RANK and RANKL2012

    • Author(s)
      Nakashima T, et.al.
    • Journal Title

      Encyclopedia of Signaling Molecules

      Pages: 1581-1589

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intracellular and extracellular ATP coordinately regulate the inverse correlation between osteoclast survival and bone resorption.2012

    • Author(s)
      Miyazaki T, Iwasawa M
    • Journal Title

      J Biol Chem.

      Volume: 287(45) Issue: 45 Pages: 34808-23

    • DOI

      10.1074/jbc.m112.385369

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 骨代謝における骨細胞の新たな役割2012

    • Author(s)
      中島友紀
    • Journal Title

      Medical Practice

      Volume: 29 Pages: 1925-1928

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 骨細胞による骨恒常性の制御2012

    • Author(s)
      中島友紀
    • Journal Title

      リウマチ科

      Volume: 48 Pages: 352-361

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 骨細胞による骨リモデリング制御2012

    • Author(s)
      中島友紀
    • Journal Title

      THE BONE

      Volume: 26 Pages: 5-10

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 骨細胞による骨吸収制御2012

    • Author(s)
      中島友紀
    • Journal Title

      CLINICAL CALCIUM

      Volume: 22 Pages: 85-96

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 骨免疫学からみたRA治療の新展開2012

    • Author(s)
      中島友紀
    • Journal Title

      最新医学

      Volume: 62 Pages: 203-211

    • Related Report
      2012 Annual Research Report
  • [Presentation] RANKL Biology2014

    • Author(s)
      中島友紀
    • Organizer
      第32回日本骨代謝学会 日韓合同シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2014-07-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 炎症と骨破壊2014

    • Author(s)
      中島友紀
    • Organizer
      第32回日本骨代謝学会 日本リウマチ学会合同シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2014-07-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 骨と運動器の連環システム2014

    • Author(s)
      中島友紀
    • Organizer
      第32回日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2014-07-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Osteocyte-derived RANKL in bone remodeling2012

    • Author(s)
      Tomoki Nakashima
    • Organizer
      American Socuety for Bone and Mineral Research 2012 Annual Meeting
    • Place of Presentation
      Minneapolis USA
    • Year and Date
      2012-09-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] Osteoprotection by semaphoring 3A2012

    • Author(s)
      Tomoki Nakashima
    • Organizer
      22^(nd) Annual Scientific Meeting ANZBMS and Asia-Pacific Bone and Mineral Research Meeting
    • Place of Presentation
      Australia(招待講演)
    • Year and Date
      2012-09-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] 骨細胞による破骨細胞分化の制御機構2012

    • Author(s)
      中島友紀
    • Organizer
      第30回日本骨代謝学会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2012-07-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] 骨リモデリングの制御機構の解明2012

    • Author(s)
      中島友紀
    • Organizer
      第30回日本骨代謝学会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2012-07-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] 骨リモデリングの制御機構の解明2012

    • Author(s)
      中島友紀
    • Organizer
      第33回日本炎症・再生医学会
    • Place of Presentation
      福岡(招待講演)
    • Year and Date
      2012-07-05
    • Related Report
      2012 Annual Research Report
  • [Presentation] 骨リモデリングの制御機構の解明2012

    • Author(s)
      中島友紀
    • Organizer
      第54回日本老年医学会学術集会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2012-06-29
    • Related Report
      2012 Annual Research Report
  • [Presentation] 骨リモデリングの制御機構の解明2012

    • Author(s)
      中島友紀
    • Organizer
      第12回日本抗加齢医学会総会
    • Place of Presentation
      横浜(招待講演)
    • Year and Date
      2012-06-24
    • Related Report
      2012 Annual Research Report
  • [Presentation] 骨リモデリングの制御機構の解明2012

    • Author(s)
      中島友紀
    • Organizer
      第66回日本口腔科学会学術集会
    • Place of Presentation
      広島(招待講演)
    • Year and Date
      2012-05-16
    • Related Report
      2012 Annual Research Report
  • [Presentation] RANKLと骨免疫学2012

    • Author(s)
      中島友紀
    • Organizer
      第56回日本リウマチ学会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2012-04-28
    • Related Report
      2012 Annual Research Report
  • [Presentation] 骨細胞による骨吸収制御機構

    • Author(s)
      中島友紀
    • Organizer
      第55回歯科基礎医学会
    • Place of Presentation
      岡山(岡山コンベンションセンター)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] RANKLと骨疾患

    • Author(s)
      中島友紀
    • Organizer
      国際骨代謝学会・日本骨代謝学会第2回 合同国際会議
    • Place of Presentation
      神戸(神戸コンベンションセンター・神戸ポートピアホテル)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Regulation of bone remodeling by osteocytes.

    • Author(s)
      中島友紀
    • Organizer
      第22回国際リウマチシンポジウム/第57回日本リウマチ学会
    • Place of Presentation
      京都(国立京都国際会館)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] Semaphorins2015

    • Author(s)
      Hayashi M, Nakashima T, Takayanagi H.
    • Publisher
      Springer New York
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2012-04-24   Modified: 2019-07-29  

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