Development of TNF-receptor Antagonists which have both Anti-inflammatory Action and Bone Formation Activity and Apply Them for the Treatment of Periodontal Diseases.
| Project/Area Number |
24390413
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Functional basic dentistry
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
OHYA Keiichi 東京医科歯科大学, 歯学部, 非常勤講師 (10126211)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
AOKI Kazuhiro 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (40272603)
TAKAHASHI Mariko 東京医科歯科大学, 歯学部, 技術職員 (90334440)
二藤 彰 鶴見大学, 歯学部, 教授 (00240747)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
NIFUJI Akira 鶴見大学, 歯学部, 教授 (00240747)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
|
|---|
| Keywords | TNF拮抗薬 / 硬組織 / 破骨細胞 / 骨芽細胞 / 骨形成 / 骨吸収 / 歯周病 / 炎症性疾患 / 骨吸収阻害薬 / 骨形成促進 / 抗炎症 / DDS / ナノゲル / TNF / ペプチド薬 / BMP / ペプチドアンタゴニスト |
|---|
| Outline of Final Research Achievements |
Inflammation caused by periodontal disease, which is a typical disease of the dental region, induces jaw bone resorption. Jaw bone resorption finally promotes the loss of teeth, leading to a decline of masticatory function. So to aim the development of drug therapies that can treat and prevent periodontal disease, we examined the cyclic peptide W9, which inhibits the binding of TNF and TNF receptor. W9 peptide showed a bone resorption inhibitory action through the mechanism that inhibits the interaction of RANK / RANKL, which is important for a growth and differentiation process of osteoclasts. In addition, W9 peptide was found to possess a bone formation promoting action as shown by the detailed study of the effect of the W9 peptides on bone. Further, by exploring the DDS system of W9 peptide, the peptide was shown to be useful for the treatment of the inflammatory bone resorption disease such as the periodontal disease.
|
Report
(4 results)
Research Products
(19 results)
-
-
-
-
-
[Journal Article] Stimulation of bone formation in cortical bone of mice treated with a receptor activator of nuclear factor-κB ligand (RANKL)-binding peptide that possesses osteoclastogenesis inhibitory activity.2013
Author(s)
Furuya Y, Inagaki A, Khan M, Mori K, Penninger JM, Nakamura M, Udagawa N, Aoki K, Ohya K, Uchida K, Yasuda H
-
Journal Title
J Biol Chem
Volume: 288
Issue: 8
Pages: 5562-5571
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
[Presentation] RANKL-binding peptides increased bone formation in a murine calvarial defect model2014
Author(s)
Sugamori,Y. Honma,M. Kato,G. Tamura,Y. Furuya,Y. YasudaH, Tabata,Y. Udagawa,N. Ohya,K. Suzuki,H. Aoki,K
Organizer
アメリカ骨代謝学会2014
Place of Presentation
ヒューストン、アメリカ
Year and Date
2014-09-12 – 2014-09-15
Related Report
-
-
-
-
[Presentation] An Osteoprotegerin-like Peptide Inhibits Bone Loss in Collagen Type II-Induced Murine Arthritis.2013
Author(s)
Kato, G. Maeda, M. Alles, N. Mamun, A. Khan, M. Sugamori, Y. Takahashi, M. Tamura, Y. Murali, R. Ohya, K. Aoki, K.
Organizer
IBMS/JSBMR第2回合同国際会議
Place of Presentation
神戸/神戸コンベンションセンター・神戸ポートピアホテル
Related Report
-
-
-
-
