The role of ER stress in oral inflammatory diseases
| Project/Area Number |
24390418
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Keywords | ストレス / シグナル伝達 / 蛋白質 |
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| Outline of Final Research Achievements |
Mucosa of the oral cavity region is constantly exposed to physical stress, such as acid and alcohol, and chemical stress, such as heat. Our body possesses the system to response to these stresses. Among them, the role of macrophages is important and its dysfunction may lead to cancer by its exacerbation of inflammatory diseases. One of the most famous as a stress response in the cells is the endoplasmic reticulum stress. In this study, we investigated the stress response by LPS, which is one of the toxin from bacteria, in macrophages. Our study revealed that ER stress is closely related to the function of macrophage.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] The expression of Fn14 via mechanical stress-activated JNK contributes to apoptosis induction in osteoblasts.2014
Author(s)
Matsui, H., Fukuno, N., Kanda, Y., Kantoh, Y., Chida, T., Nagaura, Y., Suzuki, O., Nishitoh, H., Takeda, K., Ichijo, H., Sawada, Y., Sasaki, K., Kobayashi, T. and Tamura, S.
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Journal Title
J. Biol. Chem.
Volume: 289
Issue: 10
Pages: 6438-6450
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] SOD1 as a molecular switch for initiating the homeostatic ER stress respouse under zinc deficiency.2013
Author(s)
Homma, K., Fujisawa. T., Tsuburaya, N., Yamaguchi, N., Kadowaki, H., Takeda, K., Nishitoh, H., Matsuzawa, A., Naguro, I., and Ichijo, H.
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Journal Title
Molecular Cell
Volume: 52
Issue: 1
Pages: 75-86
DOI
Related Report
Peer Reviewed
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[Journal Article] Involvement of ASK1-p38 pathway in the pathogenesis of diabetes triggered by pancreatic s cell exhaustion2013
Author(s)
Yamaguchi, K., Takeda, K., Kadowaki, H., Ueda, I., Namba, Y., Ouchi, Y. Nishitoh, H. and Ichijo, H.
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Journal Title
Biochim. Biophys. Acta.
Volume: 1830
Issue: 6
Pages: 3656-3663
DOI
Related Report
Peer Reviewed
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