| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
|
|---|
| Outline of Final Research Achievements |
I performed experiments based on "Investigation into mechanisms of cancer aggressiveness by epithelial cells undergoing EMT". Using DNA microarray analyses, I explored several molecular marker proteins which are specifically expressed in epithelial cells undergoing EMT. I found that the marker proteins, Ret and Pai2, are expressed in aggressive cancer cells, whereas the marker protein (ITGA3) is in the most aggressive cells. However, ITGA3 was also expressed in fibroblast or mesenchymal cells in cancer microenvironment, as determined by immunohistochemical analyses. These findings have been published in articles and the details,includind gene Z, will be investigated by me and my collaborators.
|
