| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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| Outline of Final Research Achievements |
Pathological mechanism of chronic muscle pain associated with temporomandibular joint disease (TMD) is still unclear. Using a unique masticatory model, we examined whether macrophages (Mφ) plays roles to recover from muscle fatigue. The masticatory activity didn't increase the number of Mφ in masseter muscle. On the other hand, Mφ depletion by the administration of clodronate-liposome (i.v.) significantly decrease the masticatory-like behavior. In addition, the decrease of IL-1β expression level in the masseter followed by the impairment of IL-6 induction have been observed. Interestingly, we also confirmed that the failure of glucose uptake in skeletal muscle tissues. Our data also underscore the importance of Mφ in IL-1-mediated local interplay between autocrine myokines including IL-6 and paracrine cytokines in active skeletal muscles. This interplay is directly involved in MM performance and fatigability, perhaps mediated through maintaining muscular glucose homeostasis.
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