Development of implant/interconnected porous hydroxyapatite complex with adsorbed bFGF and poly-phosphate

• Project/Area Number: 24390435
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Prosthetic dentistry
• Research Institution: Ohu University (2013-2014); Hiroshima University (2012)
• Principal Investigator: AKAGAWA Yasumasa 奥羽大学, 歯学部, 教授 (00127599)
• Co-Investigator(Kenkyū-buntansha): KUBO Takayasu 広島大学, 病院, 講師 (60240876) ; KORETAKE Katsunori 広島大学, 大学院医歯薬保健学研究院, 助教 (50346508) ; DOI Kazuya 広島大学, 大学院医歯薬保健学研究院, 助教 (80444686) ; MORITA Koji 広島大学, 病院, 助教 (30555149)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000); Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2013: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000); Fiscal Year 2012: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
• Keywords: 複合体 / ポリリン酸 / ｂＦＧＦ / 連通多孔性ハイドロキシアパタイト / 生体材料 / インプラント / 骨再生 / アパタイト / bFGF

Outline of Final Research Achievements

We designed novel complex biomaterial to simultaneously restore bone and place implant. This complex was incorporated implant into interconnected porous calcium　hydroxyapatite (IP-CHA) with adsorbed bFGF and polyphosphate. We then tested this complex and evaluated its effect on subsequent boneregeneration and implant stability.Ｔhe results indicate that placed complex could achieve osteoconduction of newly formed bone and osseointegration at the implant interface. We concluded that the Implant/IP-CHA complex could be expected to achieve bone reconstruction and implant stability.

Research Products

• [Journal Article] Influence of implant surface topography on primary stability in a standardized osteoporosis rabbit model study． (2015)
  • Author(s): Oue H, Doi K, Oki Y, Makiahara Y, Kubo T, Perrotti V, Piattelli A, Akagawa Y, Tsuga K．
  • Journal Title: J Funct Biomater，6，143-52，2015． Volume: 6 Issue: 1 Pages: 143-152
  • DOI: 10.3390/jfb6010143
  • Peer Reviewed / Open Access
• [Journal Article] Inorganic polyphosphate adsorbed onto hydroxyapatite for guided bone regeneration: An animal study (2014)
  • Author(s): Ｄoi K, Kubo T, Takeshita R, Kajihara S, Kato S, Kawazoe Y, Shiba T, Akagawa Y.
  • Journal Title: Dental Materials Journal Volume: 33 Issue: 2 Pages: 179-186
  • DOI: 10.4012/dmj.2013-275
  • NAID: 130003394967
  • ISSN: 0287-4547, 1881-1361
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] ポリリン酸吸着人工骨の開発 (2013)
  • Author(s): 土井一矢
  • Journal Title: 日本補綴歯科学会誌 Volume: 5 Pages: 417-419
  • NAID: 10031202890
  • Peer Reviewed
• [Journal Article] Development of implant/interconnected porous hydroxyapatite complex as new concept graft material. (2012)
  • Author(s): Doi K, Oue H, Morita K, Kajihara S, Kubo T, Koretake K, Perrotti y Iezzi G, Piattelli A, Akagawa Y.
  • Journal Title: PLoS ONE Volume: 7 Issue: 11 Pages: e49051-e49051
  • DOI: 10.1371/journal.pone.0049051
  • Peer Reviewed
• [Presentation] Evaluation of implant stability in implant/interconnected pours hydroxyapatite complex (2014)
  • Author(s): Kajihara S, Doi K, Kubo T, Oue H, Makihara Y, Morita K, Kato K, Akagawa Y
  • Organizer: The 23rd European Association for Osseointegration
  • Place of Presentation: Ｒｏｍｅ
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Evaluation of implant stability in novel implant/interconnected pours calcium hydroxyapatite complex (2014)
  • Author(s): Makihara Y, Doi K, Kubo T, Oue H, Kajihara S, Morita K, Akagawa Y, Tsuga K
  • Organizer: The 9th Scientific Meeting of the Asian Academy of Osseointegration
  • Place of Presentation: Ｓａｐｐｏｒｏ
  • Year and Date: 2014-07-04 – 2014-07-05
• [Presentation] Effect of intermittent parathyroid hormone administration on primary stability in rabbit osteoporosis model (2014)
  • Author(s): Ｄoi K, Kubo T, Makihara Y, Oue H, Kato K, Oki Y, Akagawa Y, Tsuga K
  • Organizer: The 9th Scientific Meeting of the Asian Academy of Osseointegration
  • Place of Presentation: Ｓａｐｐｏｒｏ
  • Year and Date: 2014-07-04
• [Presentation] イヌ下顎骨におけるインプラント・アパタイト複合体のインプラント支持能の検討 (2014)
  • Author(s): 梶原志穂, 久保隆靖, 土井一矢, 大上博史, 牧原勇介, 森田晃司, 加藤 寛, 津賀一弘
  • Organizer: 公益社団法人日本補綴歯科学会第123回学術大会
  • Place of Presentation: 仙台
  • Year and Date: 2014-05-24 – 2014-05-25
• [Presentation] Histological and mechanical evaluation of the implants placed in the reconstructed bone by interconnected porous calcium hydroxyapatite (2013)
  • Author(s): Makihara Y, Doi K, Morita K, Kajihara S, Kubo T, Akagawa Y
  • Organizer: International college of Prosthodontists
  • Place of Presentation: イタリア（トリノ）
• [Presentation] Development of Implant/Interconnected Porous Hydroxyapatite Complex as New Concept Graft Material (2012)
  • Author(s): Doi K, Oue H, Morita K, Kajihara S, Kubo T, Perrotti V, Iezzi G, Piattelli A, Akagawa Y.
  • Organizer: European association for Osseointegration ; 20th anniversary meeting
  • Place of Presentation: Copenhagen, Denmaerk
• [Presentation] 連通多孔性ハイドロキシアパタイトによる骨再建部に対するインプラント埋入: 組織学的および力学的評価
  • Author(s): 牧原勇介，土井一矢，梶原志穂，久保隆靖，赤川安
  • Organizer: 日本口腔インプラント学会
  • Place of Presentation: 福岡
• [Presentation] 補綴治療の向上に貢献する「十分に検証された既存の技術をハイブリッドさせたバイオマテリアルの創生」
  • Author(s): 土井一矢
  • Organizer: 公益社団法人日本補綴歯科学会 第122回学術大会
  • Place of Presentation: 福岡
  • Invited