| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Outline of Final Research Achievements |
The purpose of this study was established that the molecular biologic base of new cell-transplant therapy for lost of periodontal and bone tissues by using de-differentated fat cells (DFAT). Within the limits of the present study, we demonstrated that the poly lactic-co-glycolic acid/hydroxylapatite (PLGA/ HA) composite is a promising scaffold with an appropriate stiffness and resorption rate, and that its combination with osteo-differentiated rat DFAT may be effective for bone formation in rat calvarial defects model. Furthermore, in vitro study demonstrated that the combination of bone morphogenetic protein (BMP)-9 and FK506 effectively induces osteoblastic differentiation of rDFAT cells.
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