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Antibacterial and osteogenic properties on hydrophilic-modified hydroxyapatite coating on titanium

Research Project

Project/Area Number 24390445
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Dental engineering/Regenerative dentistry
Research InstitutionShowa University

Principal Investigator

MIYAZAKI Takashi  昭和大学, 歯学部, 教授 (40175617)

Co-Investigator(Kenkyū-buntansha) SHIBATA Yo  昭和大学, 歯学部, 講師 (30327936)
MISHIMA Kenji  昭和大学, 歯学部, 教授 (50275343)
YAMADA Atsushi  昭和大学, 歯学部, 講師 (50407558)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Fiscal Year 2014: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywordsチタン / インプラント / ハイドロキシアパタイト / コーティング / 抗菌 / 細胞 / 生体適合性
Outline of Final Research Achievements

Preparation of hydroxyapatite (HA) coated titanium (Ti) by electrical discharge in a buffered physiological saline solution has several advantages over traditional techniques. Specifically, it can generate highly crystalline nanoscale HA with a thickness of 1 μm. This study examined in vitro osteoblast gene expression and antimicrobial activity against early and late colonizers of supra-gingival plaque on nanoscale HA-coated Ti prepared by discharge in a physiological buffered solution. The sintered HA and HA-coated Ti surfaces enhanced osteoblast phenotypes in comparison with the bare Ti surface. The HA-coated Ti enabled antimicrobial activity against early colonizers of supra-gingival plaques, namely Streptococcus mitis and Streptococcus gordonii. Such antimicrobial activity may be caused by the surface hydrophilicity, thereby leading to a repulsion force between the HA-coated Ti surface and the bacterial cell membranes.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (17 results)

All 2015 2014 2013 2012

All Journal Article (11 results) (of which Peer Reviewed: 10 results,  Acknowledgement Compliant: 4 results,  Open Access: 1 results) Presentation (5 results) (of which Invited: 2 results) Book (1 results)

  • [Journal Article] Bone micro-fragility caused by the mimetic aging processes in α-klotho deficient mice: in situ nanoindentation assessment of dilatational bands2015

    • Author(s)
      Maruyama N., Shibata Y., Mochizuki A., Yamada A., Maki K., Inoue T., Kamijo R., Miyazaki T.
    • Journal Title

      Biomaterials

      Volume: 47 Pages: 62-71

    • DOI

      10.1016/j.biomaterials.2015.01.004

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] In-situ quasi-static and dynamic nanoindentation tests on calcified nodules formed by osteoblasts: Implication of glucocorticoids responsible for osteoblast calcification2015

    • Author(s)
      Miyamoto S., Miyamoto Y., Shibata Y., Yoshimura K., Izumida E., Suzuki H., Miyazaki T., Maki K., Kamijo R.
    • Journal Title

      Acta Biomaterialia

      Volume: 12 Pages: 216-226

    • DOI

      10.1016/j.actbio.2014.10.038

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Enhanced in vitro biological activities generated by surface characteristics of anodically oxidized titanium- the contribution of the oxidation effect2015

    • Author(s)
      Wurihan, Yamada A., Suzuki D., Shibata Y., Kamijo R, and Miyazaki T.
    • Journal Title

      European Cells and Materials

      Volume: 29

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Strain-rate stiffening of cortical bone: observations and implications from nanoindentation experiments2014

    • Author(s)
      Maruyama N., Shibata Y., Wurihan, Swain M., Kataoka Y., Takiguchi Y., Yamada A., Maki K. and Miyazaki T.
    • Journal Title

      Nanoscale

      Volume: 6 Issue: 24 Pages: 14863-14871

    • DOI

      10.1039/c4nr03180f

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Nanoindentation tests to assess polymerization of resin-based luting cement2014

    • Author(s)
      Sato M., Fujishima A., Shibata Y., Miyazaki T.
    • Journal Title

      Dental Materials

      Volume: 30 Issue: 9 Pages: 1021-1028

    • DOI

      10.1016/j.dental.2014.05.034

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Nanomechanical properties and molecular structures of in vitro mineralized tissues on anodically oxidized titanium surfaces.2014

    • Author(s)
      Jang, I-. K., Tanaka, R., Wurihan, Suzuki, D., Shibata Y., Fujisawa, N., Tanimoto, Y., Ogura, K., Kamijo, R., Miyazaki, T.
    • Journal Title

      Nanomedicine

      Volume: 10 Issue: 3 Pages: 629-637

    • DOI

      10.1016/j.nano.2013.09.007

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lysyl oxidase like-2 reinforces unsatisfactory ossification induced by bone morphogenetic protein-2: relating nanomechanical properties and molecular changes.2013

    • Author(s)
      Shibata, Y., Suzuki, D., Wurihan, Yamada, A., Maruyama, N., Fujisawa, N., Kamijo, R., Miyazaki, T.
    • Journal Title

      Nanomedicine

      Volume: 9 Issue: 7 Pages: 1036-1047

    • DOI

      10.1016/j.nano.2013.04.008

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphology and In Vitro Behavior of Electrospun Fibrous Poly(D,L-lactic acid) for Biomedical Applications.2013

    • Author(s)
      Inami T., Tanimoto Y., Ueda M., Shibata Y., Hirayama S., Yamaguchi M., and Kasai K.
    • Journal Title

      Advances in Materials Science and Engineering

      Volume: 140643 Pages: 1-6

    • DOI

      10.1155/2013/140643

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vitro demineralization of tooth enamel subjected to two whitening regimes.2013

    • Author(s)
      Ogura K., Tanaka R., Shibata Y., Miyazaki T., Hisamitsu H.
    • Journal Title

      Journal of the American Dental Association

      Volume: 144 Issue: 7 Pages: 799-807

    • DOI

      10.14219/jada.archive.2013.0190

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new modified laser pretreatment for porcelain zirconia bonding2013

    • Author(s)
      Liu Dan
    • Journal Title

      Dental Materials

      Volume: 29 Issue: 5 Pages: 559-565

    • DOI

      10.1016/j.dental.2013.03.002

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tape-cast and sintered beta-tricalcium phosphate laminates for biomedical applications: Effect of milled A1203 fiber additives on microstructural and2012

    • Author(s)
      Tanimoto Y,
    • Journal Title

      Journal of Biomedical Materials Research Part B: Applied Biomaterials

      Volume: 100 Issue: 8 Pages: 2261-2268

    • DOI

      10.1002/jbm.b.32796

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 生体硬組織ならびに生体材料の新しい質的・理工学的評価2014

    • Author(s)
      宮崎 隆
    • Organizer
      第73回日本矯正歯科学会大会
    • Place of Presentation
      千葉 幕張
    • Year and Date
      2014-10-20 – 2014-10-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Nanomechanical Testing Technology for In Vitro Mineralized Tissue.2013

    • Author(s)
      Shibata Y., Suzuki D., Wurihan., Yamada A., Maruyama N., Kamijo R., Miyazaki T.
    • Organizer
      2nd Meeting of the International Association for Dental Research- Asia Pacific Region
    • Place of Presentation
      タイ バンコク
    • Related Report
      2013 Annual Research Report
  • [Presentation] Nanomechanical testing technology for engineered tissues2013

    • Author(s)
      Shibata Yo
    • Organizer
      THE 2ndTRILATERAL DENTAL SYMPOSIUM on “DENTAL VIRTUAL EDUCATION TODAY”
    • Place of Presentation
      日本歯科大学
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Nano mechanical testing technology for in vitro mineralized tissue on titanium2012

    • Author(s)
      Wurihan
    • Organizer
      The 1st Trilateral "Zirconia & Titanium Today"Dental Materials Science Symposium
    • Place of Presentation
      香港
    • Year and Date
      2012-10-31
    • Related Report
      2012 Annual Research Report
  • [Presentation] Contact osteogenesis of titanium implants stimulated by wire-type electric discharge machining and an irradiation of ultraviolet lamp2012

    • Author(s)
      Kataoka Y.
    • Organizer
      The 1st Trilateral "Zirconia & Titanium Today"Dental Materials Science Symposium
    • Place of Presentation
      香港
    • Year and Date
      2012-10-31
    • Related Report
      2012 Annual Research Report
  • [Book] The New Frontiers in Research for Oral Cancer2013

    • Author(s)
      Yo Shibata, Takashi Miyazaki
    • Total Pages
      209
    • Publisher
      MARUZEN PLANET
    • Related Report
      2013 Annual Research Report

URL: 

Published: 2012-04-24   Modified: 2019-07-29  

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