Development of novel implants with local administration of fluvastatin-gelatin complex

• Project/Area Number: 24390446
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Tokyo Dental College
• Principal Investigator: YOSHINARI Masao 東京歯科大学, 歯学部, 教授 (10085839)
• Co-Investigator(Renkei-kenkyūsha): MIURA Tadashi 東京歯科大学, 歯学部, 准教授 (10266570)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000); Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: フルバスタチン / 局所投与 / 薬剤徐放 / 低代謝型骨粗鬆症 / 骨形成促進 / インプラント / 母床骨改善 / スタチン / 母床骨 / 骨粗鬆症 / マイクロCT / 骨形成能 / BMP-2

Outline of Final Research Achievements

Statins were recently reported to promote the differentiation of osteoblasts produced by the stimulation of BMP-2. This study aimed to clarify the efficacy of a local administration of fluvastatin, hydrophilic statin, on the healing of bone defects in low-turnover osteoporosis patients using a fluvastatin-gelatin complex.
Fluvastatin was released gradually from fluvastatin-gelatin complex with the dissolving gelatin that enabled the local administration of the fluvastatin. The fluvastatin-gelatin complex enhanced the bone formation in low-turnover osteoporosis animals, indicating that the fluvastatin-gelatin complex is promising carrier for facilitating the bone formation in low-turnover osteoporosis patients.

Research Products

• [Journal Article] Milk basic protein supplementation enhances fracture healing in mice (2015)
  • Author(s): Yoneme H, Hatakeyama J, Danjo A, Oida H, Yoshinari M, Aijima R, Murata N, Watanabe T, Oki Y, Kido MA
  • Journal Title: Nutrition Volume: 31 Issue: 2 Pages: 399-405
  • DOI: 10.1016/j.nut.2014.08.008
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Locally Applied Fluvastatin in Low-turnover Osteoporosis Model Mouse with Femur Bone Defect (2015)
  • Author(s): Ohira T, Tanabe K, Sasaki H, Yoshinari M and Yajima Y
  • Journal Title: Journal of Hard Tissue Biology Volume: 24 Issue: 2 Pages: 147-154
  • DOI: 10.2485/jhtb.24.147
  • NAID: 130005065049
  • ISSN: 1341-7649, 1880-828X
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Osteogenic Effect of Local Administration of Fluvastatin using a Fluvastatin-gelatin Complex in Senile Osteoporosis Model Rat (2014)
  • Author(s): Yasuda H, Tanabe K, Sato T, Nomoto S, Miura T, Yoshinari M.
  • Journal Title: Journal of Hard Tissue Biology Volume: 23 Issue: 4 Pages: 389-398
  • DOI: 10.2485/jhtb.23.389
  • NAID: 130004700423
  • ISSN: 1341-7649, 1880-828X
  • Peer Reviewed / Open Access
• [Journal Article] Electrostatically Coupled State of Fluvastatin with Gelatin in Vitro (2013)
  • Author(s): Tanabe K, Miura T, Yoshinari M
  • Journal Title: Journal of Hard Tissue Biology Volume: 22 Pages: 451-454
  • NAID: 130004480616
  • Peer Reviewed
• [Journal Article] Effects of Oral Administration of Simvastatin on Bone Formation in Senile Osteoporosis Rat (2013)
  • Author(s): Ogasawara R, FuruyaY, Sasaki H, Yoshinari M, Yajima Y
  • Journal Title: Journal of Hard Tissue Biology Volume: 22 Pages: 461-472
  • NAID: 130004480618
  • Peer Reviewed
• [Journal Article] Osteogenic effect of fluvastatin combined with biodegradable gelatin-hydrogel (2012)
  • Author(s): Tanabe K, Nomoto H, Okumori N, Miura T, Yoshinari M.
  • Journal Title: Dental Materials Journal Volume: 31 Issue: 3 Pages: 489-493
  • DOI: 10.4012/dmj.2012-008
  • NAID: 10030315580
  • ISSN: 0287-4547, 1881-1361
  • Peer Reviewed
• [Presentation] 「生体多機能化インプラント」を目指して (2014)
  • Author(s): 吉成正雄
  • Organizer: 第298回東京歯科大学学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-18 – 2014-10-19
  • Invited
• [Presentation] 老人性骨粗鬆症モデルマウス（SAMP6）の骨髄細胞に対するフルバスタチンの影響 (2014)
  • Author(s): 高橋由香里，佐々木穂高，吉成正雄，矢島安朝
  • Organizer: 第298回東京歯科大学学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-18 – 2014-10-19
• [Presentation] Influence of surface topography on osteoblast-like cell behavior to zirconia (2014)
  • Author(s): Yoshinari M
  • Organizer: 18th International Microscopy Congress 2014
  • Place of Presentation: Prague, Czechoslovakia
  • Year and Date: 2014-09-07 – 2014-09-11
• [Presentation] Osteogenic effect of fluvastatin local-administration in senile osteoporosis model rat (2013)
  • Author(s): Hiromitsu Yasada, Koji Tanabe, Mai Hara, Tohru Sato, Masao Yoshinari
  • Organizer: IADR-APR 2013
  • Place of Presentation: Bangkok, Thailand
• [Presentation] Osteogenic effect of fluvastatin local- administration with biodegradable gelatin-hydrogel (2013)
  • Author(s): Masao YOSHINARI, Shinji TAKEMOTO
  • Organizer: 46th CED-IADR
  • Place of Presentation: Florence, Italy
• [Presentation] 骨粗鬆症モデルラットの骨形成に及ぼすフルバスタチン局所投与の影響 (2012)
  • Author(s): 安田博光, 田辺耕士, 佐藤 亨, 吉成正雄
  • Organizer: Japan-China Dental Conference 2012
  • Place of Presentation: 千葉市
  • Year and Date: 2012-10-20
• [Presentation] Local osteogenic effect of fluvastatin on rat calvaria : continuous observation using micro-CT system (2012)
  • Author(s): TANABE Koji, MIURA Tadashi, YOSHINAKI Masao
  • Organizer: Japan-China Dental Conference 2012
  • Place of Presentation: CHENGDU (China)
  • Year and Date: 2012-04-27
• [Book] 骨研究最前線 (2013)
  • Author(s): 骨研究からみた最新インプラント治療
  • Total Pages: 430
  • Publisher: NTS