| Budget Amount *help |
¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Statins were recently reported to promote the differentiation of osteoblasts produced by the stimulation of BMP-2. This study aimed to clarify the efficacy of a local administration of fluvastatin, hydrophilic statin, on the healing of bone defects in low-turnover osteoporosis patients using a fluvastatin-gelatin complex.
Fluvastatin was released gradually from fluvastatin-gelatin complex with the dissolving gelatin that enabled the local administration of the fluvastatin. The fluvastatin-gelatin complex enhanced the bone formation in low-turnover osteoporosis animals, indicating that the fluvastatin-gelatin complex is promising carrier for facilitating the bone formation in low-turnover osteoporosis patients.
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