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Exploration of the mechanism of branching morphogenesis for the partial regeneration of salivary gland

Research Project

Project/Area Number 24390452
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Surgical dentistry
Research InstitutionOsaka University

Principal Investigator

SAKAI TAKAYOSHI  大阪大学, 歯学研究科(研究院), 教授 (90379082)

Co-Investigator(Kenkyū-buntansha) NOHARA KANJI  大阪大学, 歯学部附属病院, 助教 (20346167)
FUKUMOTO SATOSHI  東北大学, 大学院歯学研究科, 教授 (30264253)
福本 恵美子  東北大学, 大学病院, 講師 (10264251)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Keywords唾液腺
Outline of Final Research Achievements

We are investigating the mechanism of organ development using embryonic salivary gland. The purpose of our research is the establishment of partial salivary gland regeneration. The global database of salivary gland epithelium from cleft and bud was utilized for the finding of key gene and hormone for organ development. Further challenge for the future will be to develop realistic models that integrate many types of data to establish salivary gland regeneration.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (22 results)

All 2015 2014 2013 2012

All Journal Article (13 results) (of which Peer Reviewed: 13 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (8 results) (of which Int'l Joint Research: 2 results) Book (1 results)

  • [Journal Article] Melatonin Inhibits Embryonic Salivary Gland Branching Morphogenesis by Regulating Both Epithelial Cell Adhesion and Morphology.2015

    • Author(s)
      Obana-Koshino A, Ono H, Miura J, Sakai M, Uchida H, Nakamura W, Nohara K, Maruyama Y, Hattori A, Sakai T.
    • Journal Title

      PLoS One

      Volume: 10(4) Issue: 4 Pages: e0119960-e0119960

    • DOI

      10.1371/journal.pone.0119960

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Regenerating Salivary Glands in the Microenvironment of Induced Pluripotent Stem Cells.2015

    • Author(s)
      Ono H, Obana A, Usami Y, Sakai M, Nohara K, Egusa H, Sakai T
    • Journal Title

      Biomed Res Int.

      Volume: 2015 Pages: 293570-293570

    • DOI

      10.1155/2015/293570

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Runx/Cbfb signaling regulates postnatal development of granular convoluted tubule in the mouse submandibular gland.2015

    • Author(s)
      Islam MN, Itoh S, Yanagita T, Sumiyoshi K, Hayano S, Kuremoto K, Kurosaka H, Honjo T, Kawanabe N, Kamioka H, Sakai T, Ishimaru N, Taniuchi I, Yamashiro T
    • Journal Title

      Dev Dyn.

      Volume: 244(3) Issue: 3 Pages: 488-496

    • DOI

      10.1002/dvdy.24231

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Videoendoscopic diagnosis for predicting the response to oral appliance therapy in severe obstructive sleep apnea.2014

    • Author(s)
      Sasao Y., Nohara K., Okuno K., Nakamura Y., Sakai T
    • Journal Title

      Sleep and Breathing

      Volume: 18(4) Issue: 4 Pages: 809-815

    • DOI

      10.1007/s11325-014-0947-3

    • NAID

      130005405106

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The efficacy of a lingual augmentation prosthesis for swallowing after a glossectomy: A clinical report.2014

    • Author(s)
      Okuno, K., Nohara K., Tanaka N., Sasao Y., Sakai T
    • Journal Title

      Journal of Prosthetic Dentistry

      Volume: 111(4), Issue: 4 Pages: 342-345

    • DOI

      10.1016/j.prosdent.2013.08.011

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of the Epithelial Adhesion Molecule CEACAM1 Is Important for Palate Formation2013

    • Author(s)
      Junko Mima, Aya Koshino, Kyoko Oka, Hitoshi Uchida, Yohki Hieda, Kanji Nohara, Mikihiko Kogo, Yang Chai, Takayoshi Sakai
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 4 Pages: e61653-e61653

    • DOI

      10.1371/journal.pone.0061653

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of the bolusvolume on hyoid movements in normal individuals.2013

    • Author(s)
      Ueda, N., Nohara, K., Kotani, Y., Tanaka, N., Okuno, K., Sakai, T.
    • Journal Title

      Journal of Oral Rehabilitation

      Volume: 40(7) Issue: 7 Pages: 491-499

    • DOI

      10.1111/joor.12060

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influences of swallowing volume and viscosity on regulation of levator veli palatini muscle activity during swallowing.2013

    • Author(s)
      Okuno, K., Tachimura, T., Sakai, T.
    • Journal Title

      Journal of Oral Rehabilitation

      Volume: 40(9) Issue: 9 Pages: 657-663

    • DOI

      10.1111/joor.12071

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Btbd7/Cleftin regulates cleft formation and branching morphogenesis of epithelial cells.2013

    • Author(s)
      Sakai, T., Onodera, T.
    • Journal Title

      Journal of Oral Biosciences

      Volume: 55(2) Issue: 2 Pages: 73-75

    • DOI

      10.1016/j.job.2013.03.002

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Swallowing frequency in elderly people during daily life.2013

    • Author(s)
      Tanaka, N., Nohara, K., Kotani, Y., Matsumura, M., Sakai, T.
    • Journal Title

      Journal of Oral Rehabilitation

      Volume: 40(10) Issue: 10 Pages: 744-750

    • DOI

      10.1111/joor.12085

    • NAID

      130007843698

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a swallowing frequency meter using a laryngeal microphone2012

    • Author(s)
      Tanaka N, Nohara K, Okuno K, Kotani Y, Okazaki H, Matsumura M, Sakai T
    • Journal Title

      Journal of Oral Rehabilitation

      Volume: (印刷中) Issue: 6 Pages: 411-420

    • DOI

      10.1111/j.1365-2842.2012.02293.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 口腔内装置治療により睡眠時無呼吸症候群に伴う心室性期外収縮が改善した1症例2012

    • Author(s)
      奥野健太郎、佐々生康宏、野原幹司、阪井丘芳
    • Journal Title

      日本口腔科学会雑誌

      Volume: 61 Pages: 332-336

    • NAID

      10031144865

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高齢者施設入所者の食事支援における食事リスク判定タグの試み2012

    • Author(s)
      金子信子、野原幹司、阪井丘芳、光山誠
    • Journal Title

      老年歯科医学

      Volume: 27 Pages: 18-24

    • NAID

      10031137192

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Models of salivary gland differentiation using induced pluripotent stem (iPS) cells.2015

    • Author(s)
      Ono H, Obana A, Usami Y, Sakai M, Miura J, Egusa H, Sakai T
    • Organizer
      47th Meeting of Continental European Division of the International Association for Dental Research
    • Place of Presentation
      Antalya (Turkey)
    • Year and Date
      2015-09-14
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The change in coordination of swallowing and respiration in sleep stages.2015

    • Author(s)
      Okuno k, Nohara k, Sakai T, Lowe AA, Almeida FR
    • Organizer
      American Thoracic Society 2015 International Conference
    • Place of Presentation
      Colorado (USA)
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Melatonin regulates the branching murphogenesis of embryonic salivary gland by adjusting the adhesion and morphology of epithelial ceils2013

    • Author(s)
      Sakai T.
    • Organizer
      The gth Annual Meeting of Gordon Conference Salivary Gland : and Exosrine Bjology
    • Place of Presentation
      (招待講演)
    • Year and Date
      2013-02-04
    • Related Report
      2012 Annual Research Report
  • [Presentation] The relationship between CEACAM1 and TGFβ in palatal fusion. 12th international congress on cleft lip/palate and related craniofacial anomalies.2013

    • Author(s)
      Sakai, T., Koshino, A., Ono, H., Uchida, H., Mima, J., Hieda, Y., Nohara, K., Koga, M., Chai, Y., Oka, K.
    • Organizer
      12th international congress on cleft lip/palate and related craniofacial anomalies
    • Place of Presentation
      Florida, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] A comparison of the prevalences of speech sound errors in Japanese children with or without cleft palate.2013

    • Author(s)
      Sugiyama, C., Nohara, K., Takai, E., Sakai, T.
    • Organizer
      12th international congress on cleft lip/palate and related craniofacial anomalies
    • Place of Presentation
      Florida, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] An investigation of relationship between articulation and motor coordination in individuals with cleft palate.2013

    • Author(s)
      Sugiyama, C., Nohara, K., Hikage, A., Miyamoto, K., Koshino, A., Okuno, K., Sakai, T.
    • Organizer
      12th international congress on cleft lip/palate and related craniofacial anomalies.
    • Place of Presentation
      Florida, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Videofluorographic study of velar velocity during speech and swallowing in adults with/without cleft palate.2013

    • Author(s)
      Takai, E., Nohara, K., Sato, K., Sugiyama, C., Sakai, T.
    • Organizer
      12th international congress on cleft lip/palate and related craniofacial anomalies.
    • Place of Presentation
      Florida, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Cephalometric analysis of patients with complete unilateral cleft lip and palate following the early two-stage palatoplasty.2013

    • Author(s)
      Otsuki, K., Yamanishi, T., Yamamoto, T., Fujibayashi, E., Hiroishi, S., Tsuji, T., Seikai, T., Nohara, K., Sakai, T., Kogo, M.
    • Organizer
      2th international congress on cleft lip/palate and related craniofacial anomalies.
    • Place of Presentation
      Florida, USA
    • Related Report
      2013 Annual Research Report
  • [Book] 摂食・嚥下機能改善と装置の作り方超入門2013

    • Author(s)
      阪井丘芳、前田芳信
    • Total Pages
      96
    • Publisher
      クインテッセンス出版株式会社
    • Related Report
      2013 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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