Immunotherapy for squamous cell carcinoma with oncolytic virus
| Project/Area Number |
24390453
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
YURA YOSHIAKI 大阪大学, 歯学研究科(研究院), 教授 (00136277)
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| Co-Investigator(Renkei-kenkyūsha) |
IWAI SOICHI 大阪大学, 歯学部附属病院, 講師 (10362675)
HAMADA MASAKAZU 大阪大学, 大学院歯学研究科, 助教 (80506361)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Keywords | 腫瘍融解性ウイルス療法 / 単純ヘルペスウイルス1型 / 扁平上皮癌 / 腫瘍免疫 / オートファジー / 免疫細胞 / プロテオーム解析 / 変異型ヘルペスウイルス / 樹状細胞 / 細胞傷害性T細胞 / 変異型ヘルペスウイルス 1型 / immunogenic cel death / 変異型単純ヘルペスウイルス1型 / 超音波照射 / 近交系マウス / 細胞障害性T細胞 |
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| Outline of Final Research Achievements |
Oncolytic virotherapy is based on the ability of virus to destroy tumor cells. We investigated whether the oncolytic herpes simplex virus type 1 (HSV-1) RH2 exerted an enhancing effect on tumor immunity for squamous cell carcinoma. In a bilateral tumor model with synergistic mice, tumors in one side were injected with RH2 and other side tumors left untreated. The growth of tumors of RH2-treated animals was reduced in both sides than that in untreated mice, indicating the enhancement of tumor immunity by RH2. In RH2-infected SCC cells, damage-associated molecular patterns (DAMPs) were produced. Proteome analysis revealed the presence of DAPMs in the supernatants of RH2-infected cells. These results indicate that RH2 stimulates tumor immunity through the function to produce immunogenic proteins including DAMPs.
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Report
(5 results)
Research Products
(42 results)
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[Presentation] 口腔ウイルスの功罪2015
Author(s)
由良義明
Organizer
第25回日本口腔内科学会学術大会
Place of Presentation
大阪府
Year and Date
2015-09-18
Related Report
Invited
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