| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Outline of Final Research Achievements |
Treatment prognosis for oral cancer depends on local invasion and metastasis. Epithelial mesenchymal transition (EMT) is regarded as an important event in acquiring cell motility in cancer cells, and it is deeply involved in treatment resistance such as apoptosis tolerance. This study investigated the role of EMT in local invasion of oral cancer and the formation of local invasive foci. Both transcription factors Snail and Slug were involved in the EMT induction, and newly found ZIP 2 as a regulatory factor. Moreover, local invasive foci found out that the preceding EMT cells regulate the cell motility of the subsequent non-EMT cancer cells with the external factor CCN1, and elucidated the mechanism of the local invasion of oral cancer.
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