Study on the prevention therapy for the invasion and metastasis of oral cancer by the suppression of E-cadherin processing
| Project/Area Number |
24390455
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Tetsuji 広島大学, 医歯薬保健学研究院, 教授 (00169153)
新谷 智章 広島大学, 病院, 助教 (90403518)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Keywords | 口腔癌 / カドヘリン / プロセシング / アンチプラスミン / 浸潤・転移 / 細胞間接着 / 増殖能 / プラスミン / 細胞遊走 |
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| Outline of Final Research Achievements |
Transfection of oral squamous cell carcinoma (SCC) cells with a mammalian expression vector containing α2-antiplasmin cDNA reduced cyclin D1 expression and led to the suppression of the proliferation and tumorigenicity in SCC cells. Induction of α2-antiplasmin led to the decrease in β-catenin expression in the cytosol of SCC cells. Therefore, the inhibition of E-cadherin processing induced by α2-antiplasmin might down-regulate the proliferation of SCC cells via Wnt/β-catenin signaling.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Comparison of the prognosis of bisphosphonate-related osteonecrosis of the jaw caused by oral and intravenous bisphosphonates.2015
Author(s)
Shintani T, Hayashido Y, Mukasa H, Akagi E, Hoshino M, Ishida Y, Hamana T, Okamoto K, Kanda T, Koizumi K, Yoshioka Y, Tani R, Toratani S, Okamoto T
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Journal Title
Int J Oral Maxillofac Surg
Volume: in press
Issue: 7
Pages: 125-133
DOI
Related Report
Peer Reviewed / Open Access
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