Development of tailor-made intra-arterial chemotherapy using patient specific computational fluid dynamics
| Project/Area Number |
24390459
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Yokohama City University |
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Principal Investigator |
TOHNAI Iwai 横浜市立大学, 医学(系)研究科(研究院), 教授 (50172127)
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| Co-Investigator(Kenkyū-buntansha) |
IWAI Toshinori 横浜市立大学, 附属病院, 助教 (00468191)
MITSUDO Kenji 横浜市立大学, 医学部, 准教授 (70303641)
OSHIMA Mari 東京大学, 大学院情報学環, 教授 (40242127)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | 口腔癌 / 動注化学療法 / 流体解析 / シミュレーション / 血流シミュレーション / オーダーメイド |
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| Outline of Final Research Achievements |
Object of this study is to clarify anticancer drug distribution in retrograde intra-arterial chemotherapy for oral cancer using computational fluid dynamics. Carotid artery models were made using CT angiography, and catheter also was modeled. Blood flow simulation of carotid artery was performed using ultrasound data of carotid artery and peripheral vessels model. This study showed that blood flow into the lingual artery was limited even if catheter tip was located inferior branch of the lingual artery.
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Report
(4 results)
Research Products
(3 results)
