Development of tailor-made intra-arterial chemotherapy using patient specific computational fluid dynamics

• Project/Area Number: 24390459
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Yokohama City University
• Principal Investigator: TOHNAI Iwai 横浜市立大学, 医学(系)研究科(研究院), 教授 (50172127)
• Co-Investigator(Kenkyū-buntansha): IWAI Toshinori 横浜市立大学, 附属病院, 助教 (00468191) ; MITSUDO Kenji 横浜市立大学, 医学部, 准教授 (70303641) ; OSHIMA Mari 東京大学, 大学院情報学環, 教授 (40242127)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2012: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
• Keywords: 口腔癌 / 動注化学療法 / 流体解析 / シミュレーション / 血流シミュレーション / オーダーメイド

Outline of Final Research Achievements

Object of this study is to clarify anticancer drug distribution in retrograde intra-arterial chemotherapy for oral cancer using computational fluid dynamics. Carotid artery models were made using CT angiography, and catheter also was modeled. Blood flow simulation of carotid artery was performed using ultrasound data of carotid artery and peripheral vessels model. This study showed that blood flow into the lingual artery was limited even if catheter tip was located inferior branch of the lingual artery.

Research Products

• [Presentation] 口腔癌に対する逆行性動注化学療法における流体解析を用いた抗癌剤分配シミュレーション (2015)
  • Author(s): 北島大朗，岩井俊憲，大原良仁，矢島康治，光藤健司，大島まり，藤内 祝
  • Organizer: 第39回日本頭頸部癌学会，第4回アジア頭頸部癌学会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市中央区）
  • Year and Date: 2015-06-04 – 2015-06-06
• [Presentation] 流体解析を用いた動注化学療法の抗癌剤分配シミュレーション (2014)
  • Author(s): 北島大朗，岩井俊憲，大原良仁，矢島康治，光藤健司，藤内 祝
  • Organizer: 第38回日本頭頸部癌学会総会・学術講演会
  • Place of Presentation: 東京ファッションタウンビル（東京都江東区）
  • Year and Date: 2014-06-12 – 2014-06-13
• [Presentation] Novel computer assisted simulation and navigation in oral and maxillofacial surgery (2013)
  • Author(s): Ｉｗａｉ Ｔ．
  • Organizer: 第58回日本口腔外科学会総会・学術大会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）