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Pathogenic mechanism for aggravation of inflammatory bowel diseases caused by oral bacteria and specification of highly virulent strains

Research Project

Project/Area Number 24390461
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionOsaka University

Principal Investigator

NAKANO Kazuhiko  大阪大学, 歯学研究科(研究院), 教授 (00379083)

Co-Investigator(Kenkyū-buntansha) NOMURA Ryota  大阪大学, 歯学研究科, 准教授 (90437385)
NEMOTO Hirotoshi  大阪大学, 歯学研究科, 招へい教員 (80527226)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
KeywordsStreptococcus mutans / 炎症性腸炎 / マウスモデル / 血液 / 肝臓 / サイトカイン / Streptococcus sanguinis / 口腔レンサ球菌 / 腸炎 / 肝臓実質細胞 / 免疫機構 / コラーゲン結合タンパク / 口腔細菌 / レンサ球菌 / う蝕原性細菌 / 貪食能 / 血清型特異多糖抗原 / 貧食能
Outline of Final Research Achievements

Streptococcus mutans, a pathogen of dental caries, is known to cause several systemic diseases when invading the bloodstream. In this study, analyses of S. mutans causing inflammatory bowel diseases in a mouse model revealed that some strains also aggravated colitis. Investigation of that mechanism of aggravation revealed that the strains were localized in hepatic tissue, which secreted several cytokines related to aggravation, while binding was associated with the cell surface collagen-binding protein of strains that had invaded the bloodstream. In addition, other oral streptococcal species including Streptococcus sanguinis were also shown to aggravate colitis.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (5 results)

All 2014 2012

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Aggravation of inflammatory bowel diseases by oral streptococci.2014

    • Author(s)
      Kojima A, Nomura R, Naka S, Okawa R, Ooshima T, Nakano K.
    • Journal Title

      Oral Diseases

      Volume: 20 Issue: 4 Pages: 359-366

    • DOI

      10.1111/odi.12125

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Streptococcus mutans が誘発する腸炎悪化メカニズムの解析2014

    • Author(s)
      小島あゆち
    • Journal Title

      小児歯科学雑誌

      Volume: 52 Pages: 471-479

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Infection of specific strains of Streptococcus mutans, oral bacteria, confers a risk of ulcerative colitis2012

    • Author(s)
      Kojima A, Nakano K, Wada K, Takahashi H, Katayama K, Yoneda M, Higurashi T, Nomura R, Hokamura K, Muranaka Y, Matsuhashi N, Umemura K, Kamisaki Y, Nakajima A, Ooshima T.
    • Journal Title

      Scientific Reports

      Volume: 2 Issue: 1 Pages: 332-332

    • DOI

      10.1038/srep00332

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Streptococcus mutansの引き起こす腸炎悪化におけるIFN- γ の役割に対する分析2012

    • Author(s)
      小島あゆち, 仲野和彦, 野村良太, 大嶋隆
    • Organizer
      第50回日本小児歯科学会記念大会
    • Place of Presentation
      東京
    • Year and Date
      2012-05-12
    • Related Report
      2012 Annual Research Report
  • [Presentation] Aggravation of inflammatory bowel diseases by Streptococcus sanguinis.2012

    • Author(s)
      Kojima A, Nomura R, Ooshima T, Nakano K.
    • Organizer
      91st Meeting of International Association of Dental Research
    • Place of Presentation
      Seattle, USA.
    • Year and Date
      2012-03-20
    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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