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Molecular mechanisms of mechanical response of mandibular condylar cartilage cells during chondrogenic differentiation.

Research Project

Project/Area Number 24390462
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionKyushu University

Principal Investigator

TAKAHASHI ICHIRO  九州大学, 歯学研究科(研究院), 教授 (70241643)

Co-Investigator(Kenkyū-buntansha) HARUYAMA Naoto  九州大学, 病院, 講師 (70359529)
TERAO Fumie  九州大学, 大学院歯学研究院, 助教 (10510018)
Co-Investigator(Renkei-kenkyūsha) UMEDA Mariko  九州大学, 病院, 医員 (40707618)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Keywords歯学 / 細胞・組織 / 再生医療 / 下顎頭軟骨 / 発生・分化 / ストレス / 軟骨細胞 / シグナル伝達
Outline of Final Research Achievements

To investigate the mechanism of mechanical stress-induced inhibition of chondrogenic differentiation, we applied the mechanical tensile force to micromass cell culture from mouse embryonic limb bud or mandibular condylar cartilage (MCC). Mechanical stretching enhanced the expression of Caspase-3, and repressed the expression of Caveolin-1, Galectin-3, Patched in MCC micromass culture by antibody array analysis. Immunohistochemical analysis showed up-regulation of Caveolin-1, Galectin-3 and Patched during MCC development. These results indicate that Caveolin-1, Galectin-3 and Patched are associated specifically with as mechanical response of cartilage differentiation in MCC.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (11 results)

All 2014 2013 2012

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] Adhesive and Migratory Effects of Phosphophoryn Are Modulated by Flanking Peptides of the Integrin Binding Motif.2014

    • Author(s)
      Suzuki S, Kobuke S, Haruyama N, Hoshino H, Kulkarni AB, Nishimura F
    • Journal Title

      PLoS One

      Volume: 9(11) Issue: 11 Pages: e112490-e112490

    • DOI

      10.1371/journal.pone.0112490

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between tne stability of muscle activity in the masseter muscle and craniofacial morphology.2013

    • Author(s)
      Nakamura K, Hara A, et al.
    • Journal Title

      Orthodontic Waves

      Volume: (in press)

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of extraction of four premolars Oil vermilion height and lip area in patients with bimaxillary protrusion.2013

    • Author(s)
      Trisnawaty N, Ioi H, et al.
    • Journal Title

      Eur J Orthod

      Volume: (in press) Issue: 4 Pages: 521-528

    • DOI

      10.1093/ejo/cjs035

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three-dmentional analysis of the pharyngeal airway morphology ID growing Japanese females with and without cleft lip and palate.2012

    • Author(s)
      Yosh ihara MT Terajima M, et al.
    • Journal Title

      Am J Orthod Dentofacial Orthopedics

      Volume: 141

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication of carbonate apatite block from calcium sulfate by hydrothermal treatment2012

    • Author(s)
      Nomura S, Tsuru K, Valanezhad A, Matsuya S, Takahashi I, Ishikawa K
    • Journal Title

      Key Engineering Materials

      Volume: 493-494 Pages: 139-142

    • DOI

      10.4028/www.scientific.net/kem.493-494.139

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of buccal corridors on smile esthetics in Japanese and Korean orthodontists and orthodontic patients.2012

    • Author(s)
      Ioi H, Kang S, Shimomura T, Kim SS, Park SB, Son WS, Takahashi I.
    • Journal Title

      Am J Orthod Dentofacial Orthop

      Volume: 142 Issue: 4 Pages: 459-465

    • DOI

      10.1016/j.ajodo.2012.05.011

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 上下顎臼圧下によるvertical controlにより骨格的開咬の改善を予知的に行なった成人開咬症例2012

    • Author(s)
      因絵美子、高橋一郎
    • Journal Title

      九矯歯誌

      Volume: 8 Pages: 35-44

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 鋏状咬合および顎関節症を伴うskeletal Class l 叢生症例-矯正治療過程における顎関節疼痛の変化について2012

    • Author(s)
      辻恭子、高橋一郎
    • Journal Title

      九矯歯誌

      Volume: 8 Pages: 45-52

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 上顎両側犬歯の水平埋伏を伴うAngel Class II症例2012

    • Author(s)
      柳田奈津美、寺嶋雅彦、高橋一郎
    • Journal Title

      九矯歯誌

      Volume: 8 Pages: 69-76

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Real-time Monitoring of Intracellular ERK in ATDC5 Under Mechanical Stress2013

    • Author(s)
      Terao F, et al.
    • Organizer
      General Session of International Association for Dental Research
    • Place of Presentation
      (シアトル, アメリカ)
    • Year and Date
      2013-03-23
    • Related Report
      2012 Annual Research Report
  • [Presentation] Profiling MicroRNA Expression in Mouse Mandibular Condylar Cartilage during Development2013

    • Author(s)
      Umeda M, et al.
    • Organizer
      General Session of International Association for Dental Research
    • Place of Presentation
      (シアトル, アメリカ)
    • Year and Date
      2013-03-21
    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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