Induction of cementoblastic differentiation from mesenchymal stem cells and cementogenesis on dentin surface
Project/Area Number |
24390467
|
Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Periodontal dentistry
|
Research Institution | Hiroshima University |
Principal Investigator |
KURIHARA HIDEMI 広島大学, 医歯薬保健学研究院(歯), 教授 (40161765)
|
Co-Investigator(Kenkyū-buntansha) |
KATO Kouichi 広島大学, 大学院医歯薬保健学研究院(歯), 教授 (50283875)
MIZUNO Noriyoshi 広島大学, 大学院医歯薬保健学研究院(歯), 助教 (60325181)
UCHIDA Yuushi 広島大学, 大学院医歯薬保健学研究院(歯), 助教 (40363080)
IWATA Tomoyuki 広島大学, 病院, 助教 (30418793)
OUHARA Kazuhisa 広島大学, 大学院医歯薬保健学研究院(歯), 助教 (80550425)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2012: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
|
Keywords | 間葉系幹細胞 / セメント芽細胞 / 歯周靭帯細胞 / 歯周組織再生 / マイクロRNA / マイクロRNA / セメント質形成 |
Outline of Final Research Achievements |
In this study, it was clarified that characteristically expressed genes in cementoblasts were clarified and some genes, which can play an important role in cementoblast differentiation, were determined. Furthermore, it can be suggested that some of these genes play critical role in MSC differentiation to cementoblast. Finally, much more effective periodontal regeneration is expected by expression control for characteristic genes in cementoblast differentiation of MSC.
|
Report
(4 results)
Research Products
(4 results)
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[Journal Article] Clumps of a mesenchymal stromal cell/extracellular matrix complex can be a novel tissue engineering therapy for bone regeneration.2015
Author(s)
Kittaka M, Kajiya M, Shiba H, Takewaki M, Takeshita K, Khung R, Fujita T, Iwata T, Nguyen TQ, Ouhara K, Takeda K, Fujita T, Kurihara H.
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Journal Title
Cytotherapy.
Volume: 2
Issue: 7
Pages: 48-61
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] BDNF mimetic compound LM22A-4 regulates cementoblast differentiation via the TrkB-ERK/Akt signaling cascade.2014
Author(s)
Mikihito Kajiya, Kei Takeshita, Mizuho Kittaka, Shinji Matsuda, Kazuhisa Ouhara, Katsuhiro Takeda, Takashi Takata, Masae Kitagawa, Tsuyoshi Fujita, Hideki Shiba, Hidemi Kurihara
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Journal Title
International Immunopharmacology
Volume: 19(2)
Pages: 245-252
Related Report
Peer Reviewed / Open Access
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