| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
Peptide aptamer which combines in dentin and cementum were selected and biochemistry-like inspection was performed. As pilot study, artificial protein which consist of titanium binding aptamer and BMP has been just transplanted in the muscle. Both cartilage and bone like tissues were admitted and the expression of bone related protein mRNAwas confirmed from the 3rd day by RT-PCR method. Althoug the refinement was insufficient, when it was studied just same as a pilot study using fused protein of peptide aptamar which combines in dentin and cementum and BMP, slight expression of bone related protein was admitted (un published data).
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