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Improvement of physical function and metabolic pathophysiology by the training methods for preventing muscle atrophy in elder subjects with obesity

Research Project

Project/Area Number 24390488
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Clinical nursing
Research InstitutionUniversity of Tsukuba

Principal Investigator

ARAI Emi  筑波大学, 医学医療系, 講師 (70178713)

Co-Investigator(Kenkyū-buntansha) KAWAGUCHI Takayasu  筑波大学, 医学医療系, 教授 (40214613)
WARABI Eiji  筑波大学, 医学医療系, 講師 (70396612)
SHODA Junichi  筑波大学, 医学医療系, 教授 (90241827)
江口 清  筑波大学, 医学医療系, 准教授 (00213538)
宮本 俊和  筑波大学, 人間系, 教授 (40200208)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Keywords高齢者 / 肥満 / 運動訓練法 / 廃用性筋萎縮 / 脂肪肝 / 生活習慣病 / 脂肪性肝疾患 / ハイブリッド訓練 / 代謝機能
Outline of Final Research Achievements

The number of elder obese subjects with non-alcohoic fatty liver disease (NAFLD) has increased because of sedentary lifestyles and imbalanced dietary choices. Therefore, the development of liver rehabilitaion program is needed for the elder obese subjects to practice training mehods that is simple, safe and effective. In this study, we studied the outcomes of hybrid training and acceleration training methods for elder obese subjects with NAFLD in terms of body composition, ectopic adiposity in liver and muscle, metabolic function, liver function, physical function, health-related QOL. The results show that these training methods are useful for decreasing hepatic lipid contents and improving the QOL .

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (28 results)

All 2015 2014 2013 2012

All Journal Article (13 results) (of which Peer Reviewed: 12 results,  Open Access: 5 results,  Acknowledgement Compliant: 5 results) Presentation (10 results) (of which Invited: 3 results) Book (4 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Therapeutic effect of hybrid training of voluntary and electrical muscle contractions on middle-aged obese women with NAFLD: a pilot study2015

    • Author(s)
      Oh S, Shida T, Ikeda A, Maruyama T, Eguchi K, Isobe T, Okamoto Y, Arai E, Shiba N, Shoda J
    • Journal Title

      Ther Clin Risk Manag

      Volume: 11 Pages: 371-380

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Moderate to vigorous physical activity is an important factor for managing non-alcoholic fatty liver disease: a retrospective study2015

    • Author(s)
      Oh S, Tanaka K, Chiaki K, Tsujimoto T, So R, Shida T, Shoda J
    • Journal Title

      Hepatology

      Volume: 61 Pages: 1205-1215

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Acceleration training for management of non-alcoholic fatty liver disease: a pilot study2014

    • Author(s)
      Oh S, Shida T, Onozuka T, Maruyama T, Eguchi K, Arai E, Isobe T, Okamoto Y, Someya N, Tanaka K, Tozawa A, Shoda J
    • Journal Title

      Ther Clin Risk Manag

      Volume: 10 Pages: 925-936

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Abdominal obesity: causal factor or simply a symptom of obesity-related healyh risk2014

    • Author(s)
      Oh S, Tanaka K, Noh J, So R, Tsujimoto T, Sasai H, Kim M, Shoda J
    • Journal Title

      Diabetes, Metab Syn & Obesity

      Volume: 7 Pages: 289-296

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Regular Exercise Coupled to Diet Regimen Accelerates Reduction of Hepatic Steatosis and Associated Pathological Conditions in Non-Alcoholic Fatty Liver Disease2014

    • Author(s)
      Oh S, Tanaka K, Tsujimoto T, So R, Eto M, Shoda J
    • Journal Title

      Metabolic Syndrome & Related Disorders

      Volume: 12 Pages: 290-298

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Exercise training decreases elevated serum ferritin and lipid peroxidation marker levels in middle-aged obese men with non-alcoholic fatty liver disease2013

    • Author(s)
      Oh S, Tanaka K, Warabi E, Shoda J
    • Journal Title

      Medicine & Science in Sports & Exercise

      Volume: 45 Pages: 2214-2222

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficiency of p62/Sequestosome 1 causes hyperphagia due to leptin resistance in the brain2013

    • Author(s)
      Harada H, Warabi E, Matsuki T, Yanagawa T, Okada K, Uwayama J, Ikeda A, Nakaso K, Kirii K, Noguchi N, Bukawa H, Siow R, Mann G, Shoda J, Ishii T, Sakurai T
    • Journal Title

      J Neuroscience

      Volume: 33 Pages: 14767-14777

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-4 receptor α-based hybrid peptide effectively induces antitumor activity in head and neck squamous cell carcinoma2013

    • Author(s)
      Seto K, Shoda J, Horibe T, Warabi E, Ishige K, Yamagata K, Kohno M, Yanagawa T, Bukawa H, Kawakami K
    • Journal Title

      Oncology Report

      Volume: 29 Pages: 2147-2153

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deletion of Nrf2 leads to rapid progression of steatohepatitis in mice fed atherogenic plus high-fat diet2013

    • Author(s)
      Okada K, Warabi E, Sugimoto H, Horie M, Gotoh N, Tokushige K, Hashimoto E, Utsunomiya H, Takahashi H, Ishii T, Yamamoto M, Shoda J
    • Journal Title

      J Gastroenterol

      Volume: 48 Pages: 620-632

    • NAID

      10031177013

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 加速度トレーニング-スポーツ医科学分野での有用性2013

    • Author(s)
      田中喜代次,蘇 リナ,宮木亜沙子,小野塚太郎,正田純一
    • Journal Title

      臨床スポーツ医学

      Volume: 30 Pages: 565-569

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Nrf2 inhibits hepatic iron accumulation and counteracts oxidalive2012

    • Author(s)
      Okada K, et al.
    • Journal Title

      J Gastrcenteral

      Volume: 47 Pages: 924-935

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amelioration of cisplatin- induced nephrotoxicity in Peroxiredoxin I- deficient mice.2012

    • Author(s)
      Kosuke Okada
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 71 Issue: 2 Pages: 503-509

    • DOI

      10.1007/s00280-012-2046-0

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deletion of Nrf2leads to rapid progression of steatohepatitis in mice fed atherogenic plus high-fat diet2012

    • Author(s)
      Okada K, Warabi E, Sugimoto H, Horie M,Gotoh N, Tokushige K, Hashimoto E,Utsunomiya H, Takahashi H,Ishii T,Yamamoto M, Shoda J
    • Journal Title

      J Gastroenterol

      Volume: 48 Issue: 5 Pages: 620-632

    • DOI

      10.1007/s00535-012-0659-z

    • NAID

      10031177013

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 筋萎縮予防法ハイブリッド訓練の女性NAFLD患者に対する有用性の検討2015

    • Author(s)
      丸山 剛,呉 世昶,志田隆史,新井恵美,志波直人,正田純一
    • Organizer
      第163回日本体力医学会関東地方会
    • Place of Presentation
      慶応大学(東京)
    • Year and Date
      2015-02-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝疾患に対する3次元加速度トレーニングの効果2014

    • Author(s)
      丸山 剛,呉 世昶,佐治朱美,染谷典子,志田隆史,新井恵美,磯辺智範,岡本嘉一,正田純一
    • Organizer
      第162回日本体力医学会関東地方会
    • Place of Presentation
      早稲田大学(東京)
    • Year and Date
      2014-12-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肥満者の肝臓,筋肉,インスリン抵抗性:運動の効果 シンポジウム「メデイカルフィットネス:過去,現在,未来」2014

    • Author(s)
      正田純一,田中喜代次
    • Organizer
      第69回日本体力医学会大会
    • Place of Presentation
      長崎大学(長崎)
    • Year and Date
      2014-09-19 – 2014-09-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 肥満・生活習慣病と胆道疾患(胆石・胆道がん)シンポジウム「生活習慣が消化器がんの発生に与える影響:最近の知見」2014

    • Author(s)
      正田純一,田中喜代次
    • Organizer
      第52回日本癌治療学会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2014-08-28 – 2014-08-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] NAFLD肥満者に効果的な運動療法を実践するための中高強度身体活動量の検討2014

    • Author(s)
      呉世昶, 田中喜代次, 正田純一
    • Organizer
      第50回日本肝臓学会総会
    • Place of Presentation
      ホテルニューオータニ(東京)
    • Year and Date
      2014-05-29 – 2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 過食肥満により脂肪性肝炎を自然発症するp62/Nrf2遺伝子二重欠失マウスの腸管病変とその病態的意義2013

    • Author(s)
      秋山健太郎,池田 瑛,蕨 栄治,正田純一
    • Organizer
      第49回日本肝臓学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 肥満者を対象とした加速度トレーニングの試み2013

    • Author(s)
      江口 清,丸山 剛,正田純一
    • Organizer
      第50回リハビリテーション学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 筋萎縮予防法ハイブリッド訓練の女性NAFLD患者に対する有用性の検討2013

    • Author(s)
      小野塚太郎,志田隆史,丸山 剛,江口 清,志波直人,正田純一
    • Organizer
      第68回日本体力医学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 運動と内科疾患~運動療法の有益性と不利益性の境界~ 肥満・生活習慣病と肝胆道疾患,運動療法による予防と治療2013

    • Author(s)
      正田純一,田中喜代次
    • Organizer
      第68回日本体力医学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 減量目的の運動療法が肥満者の肝病態に及ぼす影響について2012

    • Author(s)
      小野塚太郎
    • Organizer
      日本体力医学会総会
    • Place of Presentation
      岐阜
    • Related Report
      2012 Annual Research Report
  • [Book] 横山有里,正田純一:高齢者対象の運動教室における心拍数については,どのような配慮が必要でしょうか.2014

    • Author(s)
      横山有里,正田純一
    • Total Pages
      2
    • Publisher
      メデイカルフィットネス研究会
    • Related Report
      2014 Annual Research Report
  • [Book] 透析患者にも運動療法は有効なのでしょうか.お勧めの運動はあるのでしょうか.2014

    • Author(s)
      横山有里,正田純一
    • Total Pages
      2
    • Publisher
      メデイカルフィットネス研究会
    • Related Report
      2014 Annual Research Report
  • [Book] 医学のあゆみ 分子スポーツ医学2013

    • Author(s)
      正田純一
    • Total Pages
      458
    • Publisher
      医歯薬出版
    • Related Report
      2013 Annual Research Report
  • [Book] Textbook of Traditional Japanese Medicine2012

    • Author(s)
      Shoda J
    • Publisher
      Inchinkoto, Clinical efficacy and pharmacology
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 肝内胆管がんの検出2012

    • Inventor(s)
      正田純一, 他
    • Industrial Property Rights Holder
      筑波大学
    • Filing Date
      2012-04-01
    • Related Report
      2012 Annual Research Report
    • Overseas

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Published: 2012-04-24   Modified: 2019-07-29  

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