Improvement of physical function and metabolic pathophysiology by the training methods for preventing muscle atrophy in elder subjects with obesity
Project/Area Number |
24390488
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Clinical nursing
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Research Institution | University of Tsukuba |
Principal Investigator |
ARAI Emi 筑波大学, 医学医療系, 講師 (70178713)
|
Co-Investigator(Kenkyū-buntansha) |
KAWAGUCHI Takayasu 筑波大学, 医学医療系, 教授 (40214613)
WARABI Eiji 筑波大学, 医学医療系, 講師 (70396612)
SHODA Junichi 筑波大学, 医学医療系, 教授 (90241827)
江口 清 筑波大学, 医学医療系, 准教授 (00213538)
宮本 俊和 筑波大学, 人間系, 教授 (40200208)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
|
Keywords | 高齢者 / 肥満 / 運動訓練法 / 廃用性筋萎縮 / 脂肪肝 / 生活習慣病 / 脂肪性肝疾患 / ハイブリッド訓練 / 代謝機能 |
Outline of Final Research Achievements |
The number of elder obese subjects with non-alcohoic fatty liver disease (NAFLD) has increased because of sedentary lifestyles and imbalanced dietary choices. Therefore, the development of liver rehabilitaion program is needed for the elder obese subjects to practice training mehods that is simple, safe and effective. In this study, we studied the outcomes of hybrid training and acceleration training methods for elder obese subjects with NAFLD in terms of body composition, ectopic adiposity in liver and muscle, metabolic function, liver function, physical function, health-related QOL. The results show that these training methods are useful for decreasing hepatic lipid contents and improving the QOL .
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Acceleration training for management of non-alcoholic fatty liver disease: a pilot study2014
Author(s)
Oh S, Shida T, Onozuka T, Maruyama T, Eguchi K, Arai E, Isobe T, Okamoto Y, Someya N, Tanaka K, Tozawa A, Shoda J
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Journal Title
Ther Clin Risk Manag
Volume: 10
Pages: 925-936
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Deficiency of p62/Sequestosome 1 causes hyperphagia due to leptin resistance in the brain2013
Author(s)
Harada H, Warabi E, Matsuki T, Yanagawa T, Okada K, Uwayama J, Ikeda A, Nakaso K, Kirii K, Noguchi N, Bukawa H, Siow R, Mann G, Shoda J, Ishii T, Sakurai T
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Journal Title
J Neuroscience
Volume: 33
Pages: 14767-14777
Related Report
Peer Reviewed
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[Journal Article] Deletion of Nrf2 leads to rapid progression of steatohepatitis in mice fed atherogenic plus high-fat diet2013
Author(s)
Okada K, Warabi E, Sugimoto H, Horie M, Gotoh N, Tokushige K, Hashimoto E, Utsunomiya H, Takahashi H, Ishii T, Yamamoto M, Shoda J
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Journal Title
J Gastroenterol
Volume: 48
Pages: 620-632
NAID
Related Report
Peer Reviewed
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[Journal Article] Deletion of Nrf2leads to rapid progression of steatohepatitis in mice fed atherogenic plus high-fat diet2012
Author(s)
Okada K, Warabi E, Sugimoto H, Horie M,Gotoh N, Tokushige K, Hashimoto E,Utsunomiya H, Takahashi H,Ishii T,Yamamoto M, Shoda J
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Journal Title
J Gastroenterol
Volume: 48
Issue: 5
Pages: 620-632
DOI
NAID
Related Report
Peer Reviewed
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