Spatial and temporal analyses on the historical dispersals and natural selection in the house mouse Mus musculus

• Project/Area Number: 24405013
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 海外学術
• Research Field: Biodiversity/Systematics
• Research Institution: Hokkaido University
• Principal Investigator: Suzuki Hitoshi 北海道大学, 地球環境科学研究科(研究院), 教授 (40179239)
• Co-Investigator(Kenkyū-buntansha): SATO Jun 福山大学, 生命工学部, 准教授 (80399162)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000); Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
• Keywords: ハツカネズミ / ヒト随伴動物 / 選択的スイープ / 自然選択 / 毛色関連遺伝子 / ハプロタイプ構造解析 / アジア農耕史 / 二次的接触 / 環境適応 / 毛色多型 / 先史時代人類農耕史 / ミトコンドリアDNA / Mc1r / Asip / 系統地理学 / 人為的拡散 / 選択的一掃 / 日本列島 / 系統地理 / 毛色変異 / 野生ハツカネズミ / 味覚受容体遺伝子 / 局所適応 / ミトコンドリアＤＮＡ / 日本人の起源 / 有史以前農業の展開 / cytochrome b gene / control region

Outline of Final Research Achievements

We examined genetic variation in house mice and provide insight into the ancient divergence of the three subspecies groups, castaneus (CAS), domesticus (DOM), and musculus (MUS) in Middle East and India. We examined seven tandemly arranged nuclear genes on chromosome 8. STRUCTURE analysis suggested subdivision of CAS into two main haplogroups within the Indian subcontinent. Single-gene networks revealed gene-specific architecture for subgrouping in CAS and allelic exchange among subspecies, suggesting that the earlier onset of allopatric divergence in the predicted homeland and subsequent intermittent admixing via gene flow within and between subspecies groups. A comparison of the levels of nucleotide diversity among the gene regions revealed a less divergent state in the chromosome region containing Mc1r and its adjacent genes, indicative of a selective sweep, suggesting the involvement of natural selection in the Mc1r allelic variation.

Research Products

• [Int'l Joint Research] ヤンゴン大学/パテイン大学/ミャンマー獣医科大学(ミャンマー)
• [Int'l Joint Research] チンバサ動植物公園(マダガスカル)
• [Int'l Joint Research] ウラジオストク州立大学/生物土壌学研究所(ロシア連邦)
• [Int'l Joint Research] インドネシアLIPI科学研究所(インドネシア)
• [Int'l Joint Research] ローザンヌ大学(スイス)
• [Int'l Joint Research]
• [Journal Article] Tracing the eastward dispersal of the house mouse, Mus musculus. (2015)
  • Author(s): Suzuki H, Yakimenko V, Usuda D, Frisman F.
  • Journal Title: Genes and Environment Volume: 37 Issue: 1 Pages: 20-20
  • DOI: 10.1186/s41021-015-0013-9
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Molecular phylogenetic characterization of common murine rodents from Manipur, Northeast India (2015)
  • Author(s): Chingangbam DS,Laishram JM, Suzuki H
  • Journal Title: Genes & Genetic Systems Volume: 90 Issue: 1 Pages: 21-30
  • DOI: 10.1266/ggs.90.21
  • NAID: 130005083381
  • ISSN: 1341-7568, 1880-5779
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Estimating the molecular evolutionary rates of mitochondrial genes referring to Quaternary Ice Age events with inferred population expansions and dispersals in Japanese Apodemus. (2015)
  • Author(s): Suzuki Y, Tomozawa M, Koizumi Y, Tsuchiya K, Suzuki H
  • Journal Title: BMC Evolutionary Biology Volume: 15 Issue: 1 Pages: 187-187
  • DOI: 10.1186/s12862-015-0463-5
  • NAID: 120005663129
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Ancient onset of geographical divergence, interpopulation genetic exchange, and natural selection on the Mc1r coat-colour gene in the house mouse (Mus musculus). (2015)
  • Author(s): Sayaka Kodama, Mitsuo Nunome, Kazuo Moriwaki, Hitoshi Suzuki
  • Journal Title: Biological Journal of the Linnean Society Volume: 114 Issue: 4 Pages: 778-794
  • DOI: 10.1111/bij.12471
  • NAID: 120005743054
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effect of founding events on coat colour polymorphism of Apodemus speciosus (Rodentia: Muridae) on the Izu Islands. (2014)
  • Author(s): Morihiko Tomozawa, Mitsuo Nunome, Hitoshi Suzuki, Hirotake Ono
  • Journal Title: Biological Journal of the Linnean Society Volume: 113 Issue: 2 Pages: 522-535
  • DOI: 10.1111/bij.12348
  • Peer Reviewed
• [Journal Article] Molecular Genetic Evidence for the Place of Origin of the Pacific Rat, Rattus exulans.. (2014)
  • Author(s): Vicki Thomson, Ken P Aplin, Alan Cooper, Susan Hisheh, Hitoshi Suzuki, Ibnu Maryanto, Grace Yap, Stephen C Donnellan
  • Journal Title: PLoS ONE Volume: 9 Issue: 3 Pages: 1-12
  • DOI: 10.1371/journal.pone.0091356
  • Peer Reviewed / Open Access
• [Journal Article] Lack of association between winter coat colour and genetic population structure in the Japanese hare, Lepus brachyurus (Lagomorpha : Leporidae) (2014)
  • Author(s): Mitsuo Nunome, Gohta Kinoshita, Morihiko Tomozawa, Harumi Torii, Rikyu Matsuki, Fumio Yamada, Yoichi Matsuda, Hitoshi Suzuki
  • Journal Title: Biological Journal of the Linnean Society Volume: 111 Issue: 4 Pages: 461-776
  • DOI: 10.1111/bij.12245
  • Peer Reviewed
• [Journal Article] Distinct genetic characteristics of Sri Lankan <i>Rattus</i> and <i>Bandicota</i> (Murinae, Rodentia) inferred from mitochondrial and nuclear markers (2014)
  • Author(s): Shumpei P Yasuda, Chandika D Gamage, Nobuo Koizumi, Sanae Nishio, Rie Isozumi, Kenta Shimizu, Takaaki Koma, Takako Amada, Hitoshi Suzuki, Kumiko Yoshimatsu, Jiro Arikawa
  • Journal Title: Genes & Genetic Systems Volume: 89 Issue: 2 Pages: 71-80
  • DOI: 10.1266/ggs.89.71
  • NAID: 130004687232
  • ISSN: 1341-7568, 1880-5779
  • Peer Reviewed
• [Journal Article] Molecular phylogeny of East and Southeast Asian fossorial moles (Eulipotyphla, Talpidae). (2014)
  • Author(s): Shinohara, A., Kawada, S., Son, N. T., Koshimoto, C., Endo, H., Can, D. N. and Suzuki, H.
  • Journal Title: Journal of Mammalogy Volume: 95 Issue: 3 Pages: 455-466
  • DOI: 10.1644/13-mamm-a-135
  • Peer Reviewed / Open Access
• [Journal Article] Lack of association between winter coat colour and genetic population structure in the Japanese hare, Lepus brachyurus (Lagomorpha: Leporidae). (2014)
  • Author(s): Mitsuo Nunome, Gohta Kinoshita, Morihiko Tomozawa, Harumi Torii, Rikyu Matsuki, Fumio Yamada, Yoichi Matsuda, Hitoshi Suzuki
  • Journal Title: Biological Journal of the Linnean Society Volume: 111 Issue: 4 Pages: 461-776
  • DOI: 10.5635/ased.2013.29.4.267
  • Peer Reviewed
• [Journal Article] Selection of Rodent Species Appropriate for mtDNA Transfer to Generate Transmitochondrial Mito-Mice Expressing Mitochondrial Respiration Defects (2014)
  • Author(s): Shunkei Enoki, Akinori Shimizu, Chisato Hayashi, Hirotake Imanishi, Osamu Hashizume, Kazuyuki Mekada, Hitoshi Suzuki, Tetsuo Hashimoto, Kazuto Nakada, Jun-Ichi Hayashi
  • Journal Title: Experimental Animals Volume: 63 Issue: 1 Pages: 21-30
  • DOI: 10.1538/expanim.63.21
  • NAID: 130003391604
  • ISSN: 0007-5124, 1341-1357, 1881-7122
  • Peer Reviewed
• [Journal Article] Evolutionary and dispersal history of Eurasian house mice Mus musculus clarified by more extensive geographic sampling of mitochondrial DNA.. (2013)
  • Author(s): H Suzuki, M Nunome, G Kinoshita, K P Aplin, P Vogel, A P Kryukov, M-L Jin, S-H Han, I Maryanto, K Tsuchiya, H Ikeda, T Shiroishi, H Yonekawa, K Moriwaki
  • Journal Title: Heredity Volume: 111 Issue: 5 Pages: 375-390
  • DOI: 10.1038/hdy.2013.60
  • NAID: 120005427739
  • Peer Reviewed
• [Journal Article] Evolutionary and phylogeographic views on <i>Mc1r</i> and <i>Asip</i> variation in mammals (2013)
  • Author(s): Hitoshi Suzuki
  • Journal Title: Genes & Genetic Systems Volume: 88 Issue: 3 Pages: 155-164
  • DOI: 10.1266/ggs.88.155
  • NAID: 10031194255
  • ISSN: 1341-7568, 1880-5779
  • Peer Reviewed
• [Presentation] The long journey of the house mouse (Mus musculus) to the Japanese Islands (2015)
  • Author(s): Hitoshi Suzuki
  • Organizer: The 5th International symposium on Asian Vertebrate Species Diversity (AVIS)
  • Place of Presentation: Chulalongkorn University (タイ・バンコク市）
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] ミャンマー産ハツカネズミ亜属（subgenus Mus）の地理的分布と多様化機構 (2015)
  • Author(s): 鈴木仁、島田朋史、Thida Lay Thwe、 Khin Myat Myat Zaw、片倉賢
  • Organizer: 日本動物学会第86回大会
  • Place of Presentation: 朱鷺メッセ（新潟県・新潟市）
  • Year and Date: 2015-09-17
• [Presentation] 野生ハツカネズミ(Mus musculus)の毛色とMc1rおよびAsip遺伝子変異の解析 (2015)
  • Author(s): 佐久間有希、田中ちひろ、大舘智史城ヶ原貫通、Ranorosoa Marle Claudine、新井智、土屋公幸、鈴木仁
  • Organizer: 日本動物学会北海道支部第60回大会
  • Place of Presentation: 北海道大学理学部５号館（北海道・札幌市）
  • Year and Date: 2015-08-22
• [Presentation] Colonization History of the House Mouse Mus musculus in East Asia (2015)
  • Author(s): Hitoshi Suzuki
  • Organizer: Vth International Wildlife Management Congress (IWMC)
  • Place of Presentation: 札幌コンベンションセンター（北海道・札幌市）
  • Year and Date: 2015-07-26
  • Int'l Joint Research
• [Presentation] ハツカネズミの系統分化におけるミャンマーの空間的役割 (2014)
  • Author(s): 鈴木仁、バウム ゾウ、チダ ツオ、片倉賢、土屋公幸
  • Organizer: 日本遺伝学会第８６回大会
  • Place of Presentation: 長浜バイオ大学（長浜市）
  • Year and Date: 2014-09-19
• [Presentation] ハツカネズミ（Mus musculus）における5S ribosomal DNA（5S rDNA）の進化動態 (2014)
  • Author(s): 磯部美優・布目三夫・鈴木仁
  • Organizer: 日本遺伝学会第８６回大会
  • Place of Presentation: 長浜バイオ大学（長浜市）
  • Year and Date: 2014-09-18
• [Presentation] 日本列島の南方系ハツカネズミ(CAS subspecies group)系統の起源 (2012)
  • Author(s): 桑山崇・布目三夫・森脇和郎鵜・鈴木仁
  • Organizer: 第84回日本遺伝学会
  • Place of Presentation: 九州大学(福岡市)
  • Year and Date: 2012-09-26
• [Presentation] 北日本における野生ハツカネズミMus musculusの浸透性交雑の検出 (2012)
  • Author(s): 桑山崇・布目三夫・森脇和郎鵜・鈴木仁
  • Organizer: 日本哺乳類学会2012年度大会
  • Place of Presentation: 麻生大学(相模原市)
  • Year and Date: 2012-09-21
• [Presentation] Origin of coat color variation in the black rats in the Japanese Islands (2012)
  • Author(s): Suzuki H, Sasamori s, Nomi D, NakataK
  • Organizer: Second International Sympogium on East Asian Vertebrate Species Diversity
  • Place of Presentation: 京都大学(京都市)
  • Year and Date: 2012-07-29
• [Presentation] 北日本ハツカネズミ野生集団における5S ribosomal DNAの進化的動態
  • Author(s): 磯部美優・布目三夫・森脇和郎・鈴木仁
  • Organizer: 日本遺伝学会
  • Place of Presentation: 慶應義塾大学（横浜市）
• [Presentation] ミャンマー産ネズミ亜科４種の分子系統学的把握
  • Author(s): 鈴木 仁・ Saw Bown・ 片倉 賢
  • Organizer: 日本哺乳類学会
  • Place of Presentation: 岡山理科大学（岡山市）
• [Presentation] ヒトが関わるハツカネズミの東アジアにおける分散
  • Author(s): 鈴木仁
  • Organizer: 日本環境変異原学会
  • Place of Presentation: 岡山コンベンションセンター（岡山市）
  • Invited
• [Book] Phylogeny and biogeography of the genus Mus in Eurasia In : Macholan M, Baird s, Munclinger p, Pilek J(eds) Evolution of the House Mouse. (2012)
  • Author(s): Suzuki H. and Aplin K. P.
  • Total Pages: 526
  • Publisher: Cambridge University Press
• [Book] Origin and genetic status of Mus musculus molossinus : a typical example for reticulate evolution in the genus Mus. In : Macholan M, Baird S, Munclinger P, Pilek J (eds) Evolution of the House Mouse. (2012)
  • Author(s): Yonekawa H., Sato J. J., Suzuki H. and Moriwaki K.
  • Total Pages: 526
  • Publisher: Cambridge University Press