Spatial and temporal analyses on the historical dispersals and natural selection in the house mouse Mus musculus
Project/Area Number |
24405013
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 海外学術 |
Research Field |
Biodiversity/Systematics
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Research Institution | Hokkaido University |
Principal Investigator |
Suzuki Hitoshi 北海道大学, 地球環境科学研究科(研究院), 教授 (40179239)
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Co-Investigator(Kenkyū-buntansha) |
SATO Jun 福山大学, 生命工学部, 准教授 (80399162)
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Project Period (FY) |
2012-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
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Keywords | ハツカネズミ / ヒト随伴動物 / 選択的スイープ / 自然選択 / 毛色関連遺伝子 / ハプロタイプ構造解析 / アジア農耕史 / 二次的接触 / 環境適応 / 毛色多型 / 先史時代人類農耕史 / ミトコンドリアDNA / Mc1r / Asip / 系統地理学 / 人為的拡散 / 選択的一掃 / 日本列島 / 系統地理 / 毛色変異 / 野生ハツカネズミ / 味覚受容体遺伝子 / 局所適応 / ミトコンドリアDNA / 日本人の起源 / 有史以前農業の展開 / cytochrome b gene / control region |
Outline of Final Research Achievements |
We examined genetic variation in house mice and provide insight into the ancient divergence of the three subspecies groups, castaneus (CAS), domesticus (DOM), and musculus (MUS) in Middle East and India. We examined seven tandemly arranged nuclear genes on chromosome 8. STRUCTURE analysis suggested subdivision of CAS into two main haplogroups within the Indian subcontinent. Single-gene networks revealed gene-specific architecture for subgrouping in CAS and allelic exchange among subspecies, suggesting that the earlier onset of allopatric divergence in the predicted homeland and subsequent intermittent admixing via gene flow within and between subspecies groups. A comparison of the levels of nucleotide diversity among the gene regions revealed a less divergent state in the chromosome region containing Mc1r and its adjacent genes, indicative of a selective sweep, suggesting the involvement of natural selection in the Mc1r allelic variation.
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Report
(5 results)
Research Products
(33 results)
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[Journal Article] Distinct genetic characteristics of Sri Lankan <i>Rattus</i> and <i>Bandicota</i> (Murinae, Rodentia) inferred from mitochondrial and nuclear markers2014
Author(s)
Shumpei P Yasuda, Chandika D Gamage, Nobuo Koizumi, Sanae Nishio, Rie Isozumi, Kenta Shimizu, Takaaki Koma, Takako Amada, Hitoshi Suzuki, Kumiko Yoshimatsu, Jiro Arikawa
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Journal Title
Genes & Genetic Systems
Volume: 89
Issue: 2
Pages: 71-80
DOI
NAID
ISSN
1341-7568, 1880-5779
Related Report
Peer Reviewed
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[Journal Article] Molecular phylogeny of East and Southeast Asian fossorial moles (Eulipotyphla, Talpidae).2014
Author(s)
Shinohara, A., Kawada, S., Son, N. T., Koshimoto, C., Endo, H., Can, D. N. and Suzuki, H.
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Journal Title
Journal of Mammalogy
Volume: 95
Issue: 3
Pages: 455-466
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Selection of Rodent Species Appropriate for mtDNA Transfer to Generate Transmitochondrial Mito-Mice Expressing Mitochondrial Respiration Defects2014
Author(s)
Shunkei Enoki, Akinori Shimizu, Chisato Hayashi, Hirotake Imanishi, Osamu Hashizume, Kazuyuki Mekada, Hitoshi Suzuki, Tetsuo Hashimoto, Kazuto Nakada, Jun-Ichi Hayashi
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Journal Title
Experimental Animals
Volume: 63
Issue: 1
Pages: 21-30
DOI
NAID
ISSN
0007-5124, 1341-1357, 1881-7122
Related Report
Peer Reviewed
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[Journal Article] Evolutionary and dispersal history of Eurasian house mice Mus musculus clarified by more extensive geographic sampling of mitochondrial DNA..2013
Author(s)
H Suzuki, M Nunome, G Kinoshita, K P Aplin, P Vogel, A P Kryukov, M-L Jin, S-H Han, I Maryanto, K Tsuchiya, H Ikeda, T Shiroishi, H Yonekawa, K Moriwaki
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Journal Title
Heredity
Volume: 111
Issue: 5
Pages: 375-390
DOI
NAID
Related Report
Peer Reviewed
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