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Genome-wide DNA analysis on people with family name "Japan" in Spain who are presumed as descendants of a part of the delegation to Rope by Masamune Date

Research Project

Project/Area Number 24405017
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section海外学術
Research Field Physical anthropology
Research InstitutionNagoya University

Principal Investigator

Yamamoto Toshimichi  名古屋大学, 医学(系)研究科(研究院), 准教授 (50260592)

Co-Investigator(Kenkyū-buntansha) 斎藤 成也  国立遺伝学研究所, 集団遺伝学系, 教授 (30192587)
Co-Investigator(Renkei-kenkyūsha) TOKUNAGA Katsushi  東京大学, 大学院医学系研究科, 教授 (40163977)
Research Collaborator FUSE Nobuo (NAGASAKI Masao)  
KAWAI Yosuke  
CARRACEDO Angel  
Project Period (FY) 2012-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Keywordsハポン姓 / 日本人 / スペイン / ゲノムワイド / SNP解析 / Yハプロタイプ / ゲノム / ゲノム解析 / Y-STRs / コリア・デル・リオ / 遣欧使節
Outline of Final Research Achievements

Among 800 people with family name indicated “Japan” in Spanish lived in Coria del Rio near Seville in Spain, 50 males and 51 females wishfully donated their blood with written informed consents to perform DNA analyses to confirm tips of Japanese traces on their genomes scientifically. DNA samples were extracted in by collaborators Spain, and all of the DNA analyses were performed in Japan. Unfortunately, the results of Y-STR (STRs on Y chromosome) haplotype analysis for male samples, all of the haplotypes were not similar to Japanese ones, but close to Spanish or other countries' ones. Genome-wide SNP analysis with the Japonica Array where almost all of about 660K SNPs were specific to Japanese genome also could not revealed any Japanese traces on their genomes by comparing with those data from 8 indigenous Japanese and in Tohoku Medical Mega Bank, and from Spain DNA Bank. In future, other newly improved and developed techniques or analyses would be successful to certify this matter.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (34 results)

All 2015 2014 2013 2012 Other

All Int'l Joint Research (1 results) Journal Article (14 results) (of which Peer Reviewed: 10 results,  Acknowledgement Compliant: 1 results,  Open Access: 2 results) Presentation (18 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results) Book (1 results)

  • [Int'l Joint Research] サンティアゴ・デ・コンポステーラ大学ゲノム解析センター(スペイン)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Potential statistical differentiation between Japanese and Korean populations with about 100 STRs2015

    • Author(s)
      Toshimichi Yamamotoa, Yuuji Hiroshige, Hisae Ogawa, Takashi Yoshimoto, Shuhei Mano
    • Journal Title

      Forensic Science International: Genetics Supplement Series

      Volume: 5 Pages: e348-e349

    • DOI

      10.1016/j.fsigss.2015.09.138

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 日本人と近隣ヒト集団における多座位STRsによる遺伝統計学的判別法の検討(第1報)2015

    • Author(s)
      山本敏充,廣重優二,小川久恵,吉本高士,間野修平
    • Journal Title

      DNA多型

      Volume: 23 Pages: 128-130

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Species specificities among primates probed with commercially available fluorescence-based multiplex PCR typing kits2015

    • Author(s)
      Yuuji Hiroshige, Hiroyuki Ohtaki, Takashi Yoshimoto, Hisae Ogawa, Akira Ishii, Toshimichi Yamamoto
    • Journal Title

      Legal Medicine

      Volume: 17 Issue: 5 Pages: 326-333

    • DOI

      10.1016/j.legalmed.2015.03.006

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Identification of causative pregnancy of gestational trophoblastic neoplasia diagnosed during pregnancy by short tandem repeat analysis.2014

    • Author(s)
      Yamamoto E, Niimi K, Shinjo K, Yamamoto T, Fukunaga M, Kikkawa F.
    • Journal Title

      Gynecol Oncol Case Rep.

      Volume: 18 Pages: 3-6

    • DOI

      10.1016/j.gynor.2014.04.001

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Revertant Mutation Releases Confined Lethal Mutation, Opening Pandora' s Box : A Novel Genetic Pathogenesis2014

    • Author(s)
      Ogawa Y, Takeichi T, Kono M, Hamajima N, Yamamoto T, Sugiura K, Akiyama M
    • Journal Title

      PLoS Genet

      Volume: 10(5) Issue: 5 Pages: e1004276-e1004276

    • DOI

      10.1371/journal.pgen.1004276

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ovarian mucinous tumors arising from mature cystic teratomas--a molecular genetic approach for understanding the cellular origin.2014

    • Author(s)
      Fujii K, Yamashita Y, Yamamoto T, Takahashi K, Hashimoto K, Miyata T, Kawai K, Kikkawa F, Toyokuni S, Nagasaka T
    • Journal Title

      Hum Pathol

      Volume: 45 Issue: 4 Pages: 717-724

    • DOI

      10.1016/j.humpath.2013.10.031

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 5地域のモンゴル人におけるYハプログループ及びY-STRsハプロタイプ解析並びに日本人との比較2014

    • Author(s)
      山本敏充,廣重優二,小川久恵,吉本高士
    • Journal Title

      DNA多型

      Volume: 22 Pages: 105-108

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Y-chromosome lineage in five regional Mongolian populations2013

    • Author(s)
      Toshimichi Yamamoto, Tomoki Senda, Daiki Horiba, Masayoshi Sakuma, Yuuka Kawaguchi, Yuuichi Kano
    • Journal Title

      Forensic Science International: Genetics Supplement Series

      Volume: 4 Issue: 1 Pages: e260-e261

    • DOI

      10.1016/j.fsigss.2013.10.133

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 自然脱落毛からのSTR型検出のための判定基準2013

    • Author(s)
      廣重優二,山本敏充,吉本高士,石井晃
    • Journal Title

      日本法科学技術学会誌

      Volume: 18 Pages: 97-111

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] モンゴルの2地域ヒト集団におけるYハプログループ解析2013

    • Author(s)
      廣重優二,山本敏充,吉本高士
    • Journal Title

      DNA多型

      Volume: 21 Pages: 127-129

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Autosomal and Y-chromosomal STR markers reveal a close relationship between Hokkaido Ainu and Ryukyu islanders2012

    • Author(s)
      K. Koganebuchi, T. Katsumura, S. Nakagome, H. Ishida, S. Kawamura, H. Oota
    • Journal Title

      Anthropological Science

      Volume: 120 Issue: 3 Pages: 199-208

    • DOI

      10.1537/ase.120322

    • NAID

      10031145903

    • ISSN
      0918-7960, 1348-8570
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The history of human populations in the Japanese Archipelago inferred from genome-wide SNP data with a special reference to the Ainu and the Ryukyuan Populations.2012

    • Author(s)
      Jinam T, Nishida N, Hirai M, Kawamura S, Oota H, Umetsu K, Kimura R, Ohashi J, Tajima A, Yamamoto T, Tanabe H, Mano S, Suto Y, Kaname T, Naritomi K, Yanagi K, Niikawa N, Omoto K. Saitou N
    • Journal Title

      Journal of Human Genetics

      Volume: 57巻 Issue: 12 Pages: 787-79

    • DOI

      10.1038/jhg.2012.114

    • NAID

      10031145887

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case report of placental mesenchymal dysplasia with an increased VEGF-D expression2012

    • Author(s)
      Tomomi Kotani
    • Journal Title

      Placenta

      Volume: 33 Pages: 888-891

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 南米コロンビアのWayu族から採取されたDNAにおける家系調査2012

    • Author(s)
      山本敏充
    • Journal Title

      DNA多型

      Volume: 20 Pages: 207-210

    • Related Report
      2012 Annual Research Report
  • [Presentation] インドネシアにおける“Midi-6”のアレル頻度分布及び他のヒト集団との比較2015

    • Author(s)
      山本敏充,廣重優二,小川久恵,吉本高士,石井晃,Tuntas Dhanardhono
    • Organizer
      日本DNA多型学会第24回学術集会
    • Place of Presentation
      岡山大学創立五十周年記念館(岡山県・岡山市)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 105 座位のSTRs による日本人と近隣ヒト集団間の遺伝的異質性2015

    • Author(s)
      山本敏充,佃康司,間野修平
    • Organizer
      第69回日本人類学会大会
    • Place of Presentation
      産業技術総合研究所臨海副都心センター別館(東京都・江東区)
    • Year and Date
      2015-10-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] Analysis on Y-STRs and Y haplogroups in Indonesia2015

    • Author(s)
      Toshimichi Yamamoto, Akira Shirakawa, Tuntas Dhanardhono
    • Organizer
      7th European Association of Forensic Science Conference 2015
    • Place of Presentation
      プラハ,チェコ
    • Year and Date
      2015-09-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] Potential statistical differentiation between Japanese and Korean populations with about 100 STRs2015

    • Author(s)
      Toshimichi Yamamoto, Yuuji Hiroshige, Hisae Ogawa, Takashi Yoshimoto, Shuhei Mano
    • Organizer
      26th International Congress 2015 of the International Society of Forensic Genetics
    • Place of Presentation
      クラクフ,ポーランド
    • Year and Date
      2015-08-31
    • Related Report
      2015 Annual Research Report
  • [Presentation] 日本人における257座位の4塩基リピートSTRsのアレル頻度及び統計学的解析2015

    • Author(s)
      山本敏充,小川久恵,廣重優二,吉本高士,草野麻衣子,財津桂,石井晃
    • Organizer
      第99次日本法医学会学術全国集会
    • Place of Presentation
      高知市文化プラザかるぽーと(高知県・高知市)
    • Year and Date
      2015-06-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Further potential application of autosomal and Y-chromosomal STRs2015

    • Author(s)
      Toshimichi Yamamoto
    • Organizer
      2015 International Symposium of Forensic DNA in Law
    • Place of Presentation
      ソウル,大韓民国
    • Year and Date
      2015-03-26
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 日本人と近隣ヒト集団における多座位STRsによる遺伝統計学的判別法の検討(第1報)2014

    • Author(s)
      山本敏充,小川久恵,廣重優二,吉本高士,間野修平
    • Organizer
      日本DNA多型学会第23回学術集会
    • Place of Presentation
      ウインクあいち(愛知県・名古屋市)
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Population Genetic Study of Six Mini STR ‘Midi-6’ System in Indonesian Population2014

    • Author(s)
      Tuntas Dhanardhono, Toshimichi Yamamoto, Sigid Kirana, Kunthi Yulianti, Rika Susanti, Erwin Kristanto, Akira Ishii
    • Organizer
      International Association of Forensic Science 2014
    • Place of Presentation
      ソウル,大韓民国
    • Year and Date
      2014-10-15
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Y-STR haplotype network analysis in Mongolian populations2014

    • Author(s)
      Toshimichi Yamamoto, Yuuji Hiroshige, Hisae Ogawa, Tomoki Senda, Daiki Horiba, Masatoshi Sakuma, Yuuka Kawaguchi, Yuuichi Kano, Kei Zaitsu, Takashi Yoshimoto, Akira Ishii
    • Organizer
      9th International Symposium on Advances in Legal Medicine
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2014-06-16
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Network analysis for Y-STRs among ethnic minority groups in South America2014

    • Author(s)
      Toshimichi Yamamoto, Hajime Araki, Masatoshi Sakuma, Yuuka Kawaguchi, Yuuichi Kano, Tomoki Senda, Daiki Horiba, Inaho Danjoh, Yukio Nakamura
    • Organizer
      English Speaking Working Groups-International Society of Forensic Genetics 2014
    • Place of Presentation
      アテネ,ギリシャ
    • Year and Date
      2014-05-28
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Y-chromosome lineage in five regional Mongolian populations2013

    • Author(s)
      Toshimichi Yamamoto, Tomoki Senda, Daiki Horiba, Masayoshi Sakuma, Yuuka Kawaguchi, Yuuichi Kano
    • Organizer
      25th Internation ociety of Forensic Genetics
    • Place of Presentation
      メルボルン,オーストラリア
    • Related Report
      2013 Annual Research Report
  • [Presentation] モンゴルの2地域ヒト集団におけるYハプログループ解析2012

    • Author(s)
      山本敏充
    • Organizer
      日本DNA多型学会第21回学術集会
    • Place of Presentation
      京都
    • Year and Date
      2012-11-08
    • Related Report
      2012 Annual Research Report
  • [Presentation] 南米少数民族におけるYハプログループの比較2012

    • Author(s)
      山本敏充
    • Organizer
      第66回日本人類学会大会
    • Place of Presentation
      東京
    • Year and Date
      2012-11-04
    • Related Report
      2012 Annual Research Report
  • [Presentation] Y-haplogrouping among ethnic minority groups in South America2012

    • Author(s)
      Toshimichi Yamamoto
    • Organizer
      DNA in Forensics 2012
    • Place of Presentation
      Innsbruck, Austria
    • Year and Date
      2012-09-07
    • Related Report
      2012 Annual Research Report
  • [Presentation] 2つの座位で突然変異が観察された親子鑑定の肯定例2012

    • Author(s)
      山本敏充
    • Organizer
      第96次日本法医学会全国学術集会
    • Place of Presentation
      浜松
    • Year and Date
      2012-06-08
    • Related Report
      2012 Annual Research Report
  • [Presentation] “Midi-6”システムが有効であったパラフィンブロックからの親子鑑定例

    • Author(s)
      山本敏充,吉本高士,廣重優二,財津桂,石井晃
    • Organizer
      第97次日本法医学会学術全国集会
    • Place of Presentation
      ロイトン札幌(札幌市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Network analysis for Y-STRs haplotypes among ethnic minority groups in South America

    • Author(s)
      山本敏充,檀上稲穂,中村幸夫
    • Organizer
      第67回日本人類学会大会
    • Place of Presentation
      国立科学博物館筑波研究施設(つくば市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 5地域のモンゴル人におけるYハプログループ及びY-STRsハプロタイプ解析並びに日本人との比較

    • Author(s)
      山本敏充,廣重優二,小川久恵,吉本高士
    • Organizer
      日本DNA多型学会第22回学術集会
    • Place of Presentation
      仙台市戦災復興記念館(仙台市)
    • Related Report
      2013 Annual Research Report
  • [Book] 人種は存在しない2013

    • Author(s)
      ベルトラン・ジョルダン(監修:山本敏充)
    • Total Pages
      235
    • Publisher
      中央公論新社
    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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