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Cancer prevention based on the review for pollution of well drinking water in Asia

Research Project

Project/Area Number 24406002
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section海外学術
Research Field Risk sciences of radiation/Chemicals
Research InstitutionNagoya University

Principal Investigator

Kato Masashi  名古屋大学, 医学(系)研究科(研究院), 教授 (10281073)

Co-Investigator(Kenkyū-buntansha) YAJIMA Ichiro  名古屋大学, 大学院医学系研究科, 講師 (80469022)
TAKEDA Kozue  中部大学, 生命健康科学部, 准教授 (80345884)
YAMANOSHITA Osamu  中部大学, 生命健康科学部, 講師 (50424924)
GOTO Yuji  中部大学, 生命健康科学部, 助手 (70362522)
Co-Investigator(Renkei-kenkyūsha) OHGAMI Nobutaka  名古屋大学, 大学院医学系研究科, 講師 (80424919)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Keywords飲用井戸水 / 発癌リスク / 皮膚癌 / 国際研究者交流 / バングラデシュ / ヒ素 / 疫学 / Placental Growth Factor / 元素 / 発癌毒性 / 飲用水 / 井戸水 / 浄化剤
Outline of Final Research Achievements

Previous studies showed that inorganic matters caused severe diseases that directly affect human life such as cancers. Therefore, health risk of inorganic matters in well drinking water should be considered as first priority. In this study, we first review the pollution of inorganic mattes in well drinking water through our fieldwork in Asian countries. We then evaluate cancer toxicity of inorganic matters with considering plural exposure as well as sole exposure. We finally identify the inorganic matters to be removed from well drinking water. Thus, this study will contribute to the improvement of public health through evaluation of health risk of inorganic matters in drinking water in Asian countries.

Report

(4 results)
  • 2015 Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (38 results)

All 2015 2014 2013 2012 Other

All Journal Article (18 results) (of which Peer Reviewed: 17 results,  Open Access: 5 results,  Acknowledgement Compliant: 5 results) Presentation (13 results) (of which Invited: 2 results) Remarks (5 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Protective effects of Phyllanthus emblica leaf extract on sodium arsenite-mediated adverse effects in mice.2015

    • Author(s)
      Sayed S, Ahsan N, Kato M, Ohgami N, Rashid A, Akhand AA.
    • Journal Title

      Nagoya J Med Sci

      Volume: 77 Pages: 145-153

    • NAID

      120005549560

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Arsenic-mediated promotion of anchorage-independent growth through increased level of placental growth factor.2015

    • Author(s)
      Yajima I, Kumasaka MY, Ohnuma S, Ohgami N, Naito H, Shekhar HU, Omata Y, Kato M.
    • Journal Title

      J Invest Dermatol

      Volume: 135 Issue: 4 Pages: 1147-1156

    • DOI

      10.1038/jid.2014.514

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 安全な飲用水を供給するための「生存科学」.2015

    • Author(s)
      加藤昌志
    • Journal Title

      生存科学

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Bidirectional functions of arsenic as a carcinogen and an anti-cancer agent in human squamous cell carcinoma.2014

    • Author(s)
      Thang ND, Yajima I, Kumasaka MY, Kato M.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 5 Pages: e96945-e96945

    • DOI

      10.1371/journal.pone.0096945

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Commentary to Pastore et al (2014): Epidermal growth factor receptor signalling in keratinocyte biology: implications for skin toxicity of tyrosine kinase inhibitors2014

    • Author(s)
      K. Takeda, Y. Kawamoto, M. Iida, Y. Omata, C. Zou, M. Kato
    • Journal Title

      Arch Toxicol

      Volume: 88 Issue: 12 Pages: 2319-2320

    • DOI

      10.1007/s00204-014-1373-9

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An actin-binding protein Espin is a novel growth regulator for melanoma.2014

    • Author(s)
      Yanagishita T, Yajima I, Kumasaka MY, Iida M, Xiang L, Tamada Y, Mtsuoto Y, Watabnabe D, Kato M.
    • Journal Title

      J Invest Dermatol

      Volume: 134 Issue: 12 Pages: 2996-2999

    • DOI

      10.1038/jid.2014.249

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells2014

    • Author(s)
      F. Vegran, H. Berger, R. Boidot, G. Mignot, M. Bruchard, M. Dosset, F. Chalmin, C. Rebe, V. Derangere, B. Ryffel, M. Kato, A. Prevost-Blondel, F. Ghiringhelli, L. Apetoh
    • Journal Title

      Nature Immunology

      Volume: 15 Issue: 8 Pages: 758-766

    • DOI

      10.1038/ni.2925

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-equilibrium atmospheric pressure plasmas modulate cell cycle-related gene expressions in melanocytic tumors of RET-transgenic mice.2014

    • Author(s)
      Yajima I, Iida M, Kumasaka MY, Omata Y, Ohgami N, Chang J, Ichihara S, Hori M, Kato M.
    • Journal Title

      Exp Dermatol

      Volume: 23 Issue: 6 Pages: 424-425

    • DOI

      10.1111/exd.12415

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Non-thermal atmospheric pressure plasmas as a novel candidate for preventive therapy of melanoma.2014

    • Author(s)
      Omata Y, Iida M, Yajima I, Takeda K, Ohgami N, Masaru Hori H, Kato M.
    • Journal Title

      Environ Health Prev Med.

      Volume: 19 Issue: 5 Pages: 367-369

    • DOI

      10.1007/s12199-014-0399-1

    • NAID

      50009312844

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effects of non-thermal atmospheric pressure plasma irradiation on expression levels of matrix metalloproteinases in benign melanocytic tumors in RET-transgenic mice.2014

    • Author(s)
      Iida M,Yajima I, Ohgami N, Tamura H, Takeda K, Ichihara S, Hori M, Kato M.
    • Journal Title

      Eur J Dermatol

      Volume: 24 Issue: 3 Pages: 392-394

    • DOI

      10.1684/ejd.2014.2330

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enhanced carcinogenicity by coexposure to arsenic and iron and a novel remediation system for the elements in well drinking water.2013

    • Author(s)
      Kumasaka YM, et al.
    • Journal Title

      Arch Toxicol.

      Volume: 87 Issue: 3 Pages: 439-447

    • DOI

      10.1007/s00204-012-0964-6

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-tumor Effect of Paclitaxel is Mediated by Inhibition of MDSCs and Chronic Inflammation in the Spontaneous Melanoma Model.2013

    • Author(s)
      Sevko A, Michels T, Vrohlings M, Umansky L, Beckhove P, Kato M, Shurin GV, Shurin MR, Umansky V.
    • Journal Title

      J Immunol

      Volume: 190 Issue: 5 Pages: 2464-2471

    • DOI

      10.4049/jimmunol.1202781

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Difference in urinary arsenic metabolites between diabetic and non-diabetic subjects in Bangladesh2013

    • Author(s)
      Saika Nizam
    • Journal Title

      Int. J. Environ. Res. Public Health

      Volume: 10 Issue: 3 Pages: 1006-1019

    • DOI

      10.3390/ijerph10031006

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced GNG2 expression levels in mouse malignant melanomas and human melanoma cell lines.2012

    • Author(s)
      Yajima I, Kumasaka YM, Naito Y, Yoshikawa T, Takahashi H, Funasaka Y, Suzuki T, Kato M.
    • Journal Title

      Am J Cancer Res

      Volume: 2 Pages: 322-329

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Barium inhibits arsenic-mediated apoptotic cell death in human squamous cell carcinoma cells.2012

    • Author(s)
      Yajima I, et al.
    • Journal Title

      Arch Toxicol.

      Volume: 86 Issue: 6 Pages: 961-973

    • DOI

      10.1007/s00204-012-0848-9

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cancer-induced immunosuppression: IL-18-elicited immunoablative NK cells2012

    • Author(s)
      Terme M, Ullrich E, Aymeric L, Meinhardt K, Coudert J, Desbois M, Ghiringhelli F, Viaud S, Ryffel B, Yagita H, Chen L, Mecheri S, Kaplanski G, Prevost-Blondel A, Kato M, Schultze JL, Tartour E, Kroemer G, Degli-Esposti M, Chaput N, Zitvogel L
    • Journal Title

      Cancer Res

      Volume: 72 Issue: 11 Pages: 2757-2767

    • DOI

      10.1158/0008-5472.can-11-3379

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor-Expressed Inducible Nitric Oxide Synthase Controls Induction of Functional Myeloid-Derived2012

    • Author(s)
      Jayaraman P, Parikh F, Lopez-Rivera E, Hailemichael Y, Clark A, Ma G, Cannan D, Ramacher M, Kato M, Overwijk WW, Chen SH, Umansky VY, Sikora AG.
    • Journal Title

      J Immunol

      Volume: 188 Issue: 11 Pages: 5365-5376

    • DOI

      10.4049/jimmunol.1103553

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional analysis of GNG2 in human malignant melanoma cells.2012

    • Author(s)
      Yajima I, et al.
    • Journal Title

      J Dermatol Sci.

      Volume: 68 Issue: 3 Pages: 172-178

    • DOI

      10.1016/j.jdermsci.2012.09.009

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 飲用水を介した重金属の複合曝露の健康リスク評価2015

    • Author(s)
      熊坂真由子、田村青鳥、矢嶋伊知朗、大神信孝、飯田真智子、内藤久雄、加藤昌志
    • Organizer
      第85回 日本衛生学会学術総会
    • Place of Presentation
      和歌山県和歌山市 和歌山県民文化会館
    • Year and Date
      2015-03-27 – 2015-03-28
    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
  • [Presentation] 新規メラノーマ関連遺伝子ESPINの機能解析2014

    • Author(s)
      矢嶋伊知朗, Cunchao Zou, Xiang Li, 中野千尋, 加藤昌志
    • Organizer
      第4回生理学研究所・名古屋大学医学系研究科 合同シンホシウム
    • Place of Presentation
      愛知県名古屋市 名古屋大学
    • Year and Date
      2014-11-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] Ednrb遺伝子関連メラノーマの予防、治療に有効な遺伝子の探索2014

    • Author(s)
      熊坂真由子、矢嶋伊知朗、飯田真知子、神保佳奈、田村青鳥、大神信孝、加藤昌志
    • Organizer
      第84回 日本衛生学会学術総会
    • Place of Presentation
      岡山県岡山市 岡山コンベンションセンター
    • Year and Date
      2014-05-25 – 2014-05-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 低濃度有害重金属の飲水投与による中枢神経系組織における元素分析2014

    • Author(s)
      神保佳奈、熊坂真由子、矢嶋伊知朗、飯田真智子、田村青鳥、大神信孝、内藤久雄、加藤昌志
    • Organizer
      第84回 日本衛生学会学術総会
    • Place of Presentation
      岡山県岡山市 岡山コンベンションセンター
    • Year and Date
      2014-05-25 – 2014-05-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 環境因子により誘発される疾患の発症機構の解明と予防法の開発2014

    • Author(s)
      加藤昌志
    • Organizer
      第84回 日本衛生学会学術総会
    • Place of Presentation
      岡山県岡山市 岡山コンベンションセンター
    • Year and Date
      2014-05-25 – 2014-05-27
    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Invited
  • [Presentation] ヒ素及びバリウムに対する浄化剤の開発2014

    • Author(s)
      矢嶋伊知朗、熊坂真由子、田村青鳥、大沼章子、大神信孝、加藤昌志
    • Organizer
      第84回 日本衛生学会学術総会
    • Place of Presentation
      岡山県岡山市 岡山コンベンションセンター
    • Year and Date
      2014-05-25 – 2014-05-27
    • Related Report
      2013 Annual Research Report
  • [Presentation] 低濃度有害重金属の飲水投与における体内分布についての解析2014

    • Author(s)
      田村青鳥、矢嶋伊知朗、熊坂真由子、大沼章子、神保佳奈、大神信孝、内藤久雄、加藤昌志
    • Organizer
      第84回 日本衛生学会学術総会
    • Place of Presentation
      岡山県岡山市 岡山コンベンションセンター
    • Year and Date
      2014-05-25 – 2014-05-27
    • Related Report
      2013 Annual Research Report
  • [Presentation] バリウムの発癌毒性2014

    • Author(s)
      飯田真智子、矢嶋伊知朗、熊坂真由子、大沼章子、神保佳奈、田村青鳥、大神信孝、加藤昌志
    • Organizer
      第87回 日本産業衛生学会
    • Place of Presentation
      岡山県岡山市 岡山コンベンションセンター
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2013 Annual Research Report
  • [Presentation] 飲用井戸水の重金属複合汚染による発癌リスクに関する解析2013

    • Author(s)
      矢嶋伊知朗、熊坂真由子、Saika Nizam、Md. Khalequzzaman、Hossain U. Shekhar、大沼章子、古田昭男、那須民江、加藤昌志
    • Organizer
      第12回分子予防環境医学研究会
    • Place of Presentation
      つくばサイエンス・インフォメーションセンター(つくば市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 発癌リスクを亢進させる重金属複合汚染に有効な浄化剤の開発2013

    • Author(s)
      矢嶋伊知朗、熊坂真由子、Saika Nizam, Md. Khalequzzaman, Hossain U. Shekhar、大沼章子、古田昭男、那須民江、加藤昌志
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢大学(金沢市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Plasma-mediated modulation of element distribution in skin and skin cancer2013

    • Author(s)
      Ichiro YAJIMA, Machiko Iida, Kaoru NAKAGAWA, Hiroki KONDO Mayuko Y. KUMASAKA, Keigo TAKEDA, Masaru HORI, Hiroyuki KANO and Masashi KATO
    • Organizer
      ISPlasma2013
    • Place of Presentation
      名古屋大学(名古屋市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] メラノーマにおけるGNG2の機能2012

    • Author(s)
      矢嶋伊知朗、熊坂真由子、大神信孝、加藤昌志
    • Organizer
      第24回色素細胞学会学術大会
    • Place of Presentation
      長浜バイオ大学(長浜市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Aim of fieldwork for well drinking water2012

    • Author(s)
      Masashi Kato
    • Organizer
      JSPS AA Science Platform Program: The 3rd International Symposium of Environmental Health Sciences in Hanoi University of Technology, Vietnam
    • Place of Presentation
      Hanoi University of Technology(ベトナム)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Remarks] 名古屋大学大学院医学系研究科・医学部医学科

    • URL

      http://www.med.nagoya-u.ac.jp/medical/2511/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 名古屋大学大学院医学系研究科 環境労働衛生学

    • URL

      http://www.med.nagoya-u.ac.jp/hygiene/

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
  • [Remarks] 名古屋大学大学院医学系研究科・医学部医学科

    • URL

      http://www.med.nagoya-u.ac.jp/medical/6272/6375/kankyouroudoueiseigaku.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 名古屋大学大学院医学系研究科 教員詳細

    • URL

      http://profs.provost.nagoya-u.ac.jp/view/html/100001262_ja.html?k=%E5%8A%A0%E8%97%A4%E3%80%80%E6%98%8C%E5%BF%97

    • Related Report
      2012 Annual Research Report
  • [Remarks] 名古屋大学大学院医学系研究科 環境労働衛生学

    • URL

      http://www.med.nagoya-u.ac.jp/hygiene/

    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] メラノーマ特異的バイオマーカー及びその利用2015

    • Inventor(s)
      加藤昌志、矢嶋伊知朗、武田湖州恵、後藤友二
    • Industrial Property Rights Holder
      名古屋大学と中部大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-058692
    • Filing Date
      2015-03-20
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 幹細胞を標的とした薬効及び毒性の評価法2012

    • Inventor(s)
      飯田真智子、加藤昌志
    • Industrial Property Rights Holder
      名古屋大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-243119
    • Filing Date
      2012-11-02
    • Related Report
      2012 Annual Research Report

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Published: 2012-04-24   Modified: 2019-07-29  

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