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Construction of a program for sustainable use of traditional medicines, based on integrated study of genetic, chemical and pharmacological diversity of medicinal plants

Research Project

Project/Area Number 24406005
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section海外学術
Research Field Environmental pharmacy
Research InstitutionUniversity of Toyama

Principal Investigator

KOMATSU Katsuko  富山大学, 和漢医薬学総合研究所, 教授 (50225570)

Co-Investigator(Kenkyū-buntansha) TOHDA Chihiro  富山大学, 和漢医薬学総合研究所, 准教授 (10272931)
KADOWAKI Makoto  富山大学, 和漢医薬学総合研究所, 教授 (20305709)
ZHU Shu  富山大学, 和漢医薬学総合研究所, 助教 (20377360)
Co-Investigator(Renkei-kenkyūsha) KAZUMA Kohei  富山大学, 和漢医薬学総合研究所, その他 (70552446)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords薬用植物 / 品質評価 / 芍薬 / 刺五加 / Gentiana属生薬 / 痴呆 / アレルギー疾患 / 国際協力 / 薬用植物学 / エゾウコギ / 抗アレルギー / 抗炎症 / 分子系統学 / 秦ギョウ / 大黄 / 龍胆 / 党参
Outline of Final Research Achievements

To develop an active plan for sustainable use of herbal drug resources, field investigation on botanical sources and genetic, chemical and pharmacological analyses were performed to establish indices for standardization of 7 herbal drugs. Subsequently plants with superior or characteristic properties were selected upon integrated survey and analyses on medicinal resources related to each drug including horticultural cultivars, and their cultivation was initiated. Two cultivars were selected as candidate source for red peony root based on genetic, chemical and pharmacological characteristics. A superior strain of rhubarb with multi-components was selected. The hot water extract of leaves of hydroponic cultured siberian ginseng showed neurite outgrowth activity. In the study on 2 kinds of Gentiana drugs, genetic and chemical markers for identification besides compounds with anti-inflammatory activity were determined, which gave the information to select alternative source of these drugs.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (84 results)

All 2015 2014 2013 2012 Other

All Journal Article (25 results) (of which Peer Reviewed: 25 results,  Acknowledgement Compliant: 3 results,  Open Access: 2 results) Presentation (50 results) (of which Invited: 5 results) Book (2 results) Remarks (6 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Genetic and chemical characterization of white and red peony root derived from Paeonia lactiflora2015

    • Author(s)
      Zhu S., Yu X. L., Wu Y. Q., Shiraishi F., Kawahara N., Komatsu K.
    • Journal Title

      J. Nat. Med.

      Volume: 69 Issue: 1 Pages: 35-45

    • DOI

      10.1007/s11418-014-0857-5

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A systematic study of the influencing parameters and improvement of quantitative analysis of multi-component with single marker method using notoginseng as research subject2015

    • Author(s)
      Wang C. Q., Jia X. H., Zhu S., Komatsu K., Wang X., Cai S. Q.
    • Journal Title

      Talanta

      Volume: 134 Pages: 587-595

    • DOI

      10.1016/j.talanta.2014.11.028

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The anti-inflammatory secoiridoid glycosides from Gentianae Scabrae Radix: the root and rhizome of Gentiana scabra2015

    • Author(s)
      He Y. M., Zhu S., Ge Y. W., Kazuma K., Zou K., Cai S. Q., Komatsu K.
    • Journal Title

      J. Nat. Med.

      Volume: 印刷中 Issue: 3 Pages: 303-312

    • DOI

      10.1007/s11418-015-0894-8

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Secoiridoid glycosides from the root of Gentiana crassicaulis with inhibitory effects against LPS-induced NO and IL-6 production in RAW264 macrophages2015

    • Author(s)
      He Y. M., Zhu S., Ge Y. W., Cai S. Q., Komatsu K.
    • Journal Title

      J. Nat. Med.

      Volume: 印刷中 Issue: 3 Pages: 366-374

    • DOI

      10.1007/s11418-015-0903-y

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The genus Codonopsis (Campanulaceae): a review of phytochemistry, bioactivity and quality control2015

    • Author(s)
      He J. Y., Ma N., Zhu S., Komatsu K., Li Z. Y., Fu W. M.
    • Journal Title

      J. Nat. Med.

      Volume: 69 Issue: 1 Pages: 1-21

    • DOI

      10.1007/s11418-014-0861-9

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Shikonin, a constituent of Lithospermum erythrorhizon exhibits anti-allergic effects by suppressing orphan nuclear receptor Nr4a family gene expression as a new prototype of calcineurin inhibitors in mast cells2014

    • Author(s)
      Wang X., Hayashi S., Umezaki M., Yamamoto T., Kageyama-Yahara N., Kondo T., Kadowaki M.
    • Journal Title

      Chemico-Biological Interactions

      Volume: 224 Pages: 117-127

    • DOI

      10.1016/j.cbi.2014.10.021

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isofraxidin, a potent reactive oxygen species (ROS) scavenger, protects human leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in p53-independent manner2014

    • Author(s)
      Li P., Zhao Q. L., Wu L. H., Jawaid P., Jiao Y. F., Kadowaki M., Kondo T.
    • Journal Title

      Apoptosis

      Volume: 19 Issue: 6 Pages: 1043-1053

    • DOI

      10.1007/s10495-014-0984-1

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Arbutin, an intracellular hydroxyl radical scavenger, protects radiation-induced apoptosis in human lymphoma U937 cells2014

    • Author(s)
      Wu L. H., Li P., Zhao Q. L., Piao J. L., Jiao Y. F., Kadowaki M., Kondo T.
    • Journal Title

      Apoptosis

      Volume: 19 Issue: 11 Pages: 1654-1663

    • DOI

      10.1007/s10495-014-1032-x

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quality evaluation of medicinally-used Codonopsis species and Codonopsis Radix based on the contents of pyrrolidine alkaloids, phenylpropanoid and polyacetylenes2014

    • Author(s)
      He J. Y., Zhu S., Goda Y., Cai S. Q., Komatsu K.
    • Journal Title

      J. Nat. Med.

      Volume: 68 Issue: 2 Pages: 326-339

    • DOI

      10.1007/s11418-013-0801-0

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of a methodology for identifying Paeoniae Radix based on metallomics analysis2014

    • Author(s)
      Shimada K., Nakamura Y., Kawase M., Komatsu K., Saito T., Takahashi K.
    • Journal Title

      J. Nat. Med.

      Volume: 68 Issue: 2 Pages: 407-413

    • DOI

      10.1007/s11418-013-0795-7

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HPLC/UV analysis of polyacetylenes, phenylpropanoid and pyrrolidine alkaloids in medicinally used Codonopsis species2014

    • Author(s)
      He J. Y., Zhu S., Komatsu K.
    • Journal Title

      Phytochemical Analysis

      Volume: 25 Issue: 3 Pages: 213-219

    • DOI

      10.1002/pca.2494

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New treatment for Alzheimer’s disease, kamikihito, reverses amyloid-ß-induced progression of tau phosphorylation and axonal atrophy.2014

    • Author(s)
      Watari H, Shimada Y, Tohda C
    • Journal Title

      Evidence-Based Complementary and Alternative Medicine

      Volume: 2014 Article ID 706487 Issue: 1 Pages: 1-10

    • DOI

      10.1155/2014/706487

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Ashwagandha (roots of Withania somnifera) on neurodegenerative diseases2014

    • Author(s)
      Kuboyama T., Tohda C., Komatsu K.
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 37

    • NAID

      130004147346

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-allergic role of cholinergic neuronal pathway via α7 nicotinic ACh receptors on mucosal mast cells in a murine food allergy model2014

    • Author(s)
      Yamamoto T., Kodama T., Lee J., Utsunomiya N., Hayashi S., Sakamoto H., Kuramoto H., Kadowaki M.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 1 Pages: 85888-85888

    • DOI

      10.1371/journal.pone.0085888

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparative studies of saponins in 1-3-year-old main roots, fibrous roots, and rhizomes of Panax notoginseng, and identification of different parts and growth-year samples2013

    • Author(s)
      Jia X. H., Wang C. Q., Liu J. H., Li X. W., Wang X., Shang M. Y., Cai S. Q., Zhu S., Komatsu K.
    • Journal Title

      J. Nat. Med.

      Volume: 67 Issue: 2 Pages: 339-349

    • DOI

      10.1007/s11418-012-0691-6

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic polymorphism of medicinally-used Codonopsis species in internal transcribed spacer sequence of nuclear ribosomal DNA and its application to authenticate Codonopsis Radix2013

    • Author(s)
      He J. Y., Zhu S., Komatsu K., Goda Y., Cai S. Q.
    • Journal Title

      J. Nat. Med.

      Volume: (印刷中) Issue: 1 Pages: 112-124

    • DOI

      10.1007/s11418-013-0780-1

    • NAID

      40019919829

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diosgenin-induced cognitive enhancement in normal mice is mediated by 1,25D3-MARRS.2013

    • Author(s)
      Tohda C, Lee Y-A, Goto Y, Nemere I
    • Journal Title

      Scientific Reports

      Volume: 3 Issue: 1 Pages: 1-8

    • DOI

      10.1038/srep03395

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The molecular mechanisms and gene expression profiling for shikonin-induced apoptotic and necroptotic cell death in U937 cells2013

    • Author(s)
      Piao J. L., Cui Z. G., Furusawa Y., Ahmed K., Rehman M. U., Tabuchi Y., Kadowaki M., Kondo T.
    • Journal Title

      Chemico-Biological Interactions

      Volume: 205 Issue: 2 Pages: 119-127

    • DOI

      10.1016/j.cbi.2013.06.011

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRPM2 contributes to antigen-stimulated Ca2+ influx in mucosal mast cells2013

    • Author(s)
      Oda S., Uchida K., Wang X., Lee J., Shimada Y., Tominaga M., Kadowaki M.
    • Journal Title

      Pflugers Archiv : European journal of physiology

      Volume: 465 Issue: 3 Pages: 895-900

    • DOI

      10.1016/j.bbrc.2012.12.058

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enzymatic Cleavage of the C-Glucosidic Bond of Puerarin by Three Proteins, Mn2+, and Oxidized Form of Nicotinamide Adenine Dinucleotide2013

    • Author(s)
      Nakamura K., Komatsu K., Hattori M., Iwashima M.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 36 Issue: 4 Pages: 635-640

    • DOI

      10.1248/bpb.b12-01011

    • NAID

      130003361403

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aristololactams and aporphines from the stems of Fissistigma oldhamii(Annonaceae)2013

    • Author(s)
      Ge Y. W., Zhu S., Shang M. Y., Zang X. Y., Wang X., Bai Y. J., Komatsu K., Cai S. Q.
    • Journal Title

      Phytochem.

      Volume: 86 Pages: 201-207

    • DOI

      10.1016/j.phytochem.2012.09.011

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel compound, denosomin, ameliorates spinal cord injury via axonal growth associated with astrocyte-secreted vimentin.2013

    • Author(s)
      Teshigawara K, Kuboyama T, Shigyo M, Nagata A, Sugimoto K, Matsuya Y, Tohda C.
    • Journal Title

      British Journal of Pharmacology

      Volume: 168 Issue: 4 Pages: 903-919

    • DOI

      10.1111/j.1476-5381.2012.02211.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer’s disease pathologies in 5XFAD mice.2012

    • Author(s)
      Tohda C, Urano T, Umezaki M, Nemere I, Kuboyama T.
    • Journal Title

      Sci. Rep.,

      Volume: 2 Issue: 1 Pages: 535-535

    • DOI

      10.1038/srep00535

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epimedium koreanum extract and its constituent icariin improve motor dysfunction in spinal cord injury.2012

    • Author(s)
      Tohda C, Nagata A.
    • Journal Title

      Evidence Based Complementary and Alternative Medicine

      Volume: 2012 Pages: 731208-731208

    • DOI

      10.1155/2012/731208

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sphingosine kinase-1-dependent and -independent inhibitory effects of zanthoxyli fructus to attenuate the activation of mucosal mast cells and ameliorate food allergies in mice2012

    • Author(s)
      Wang X, Kageyama-Yahara N, Hayashi S, Yamamoto T, Kadowaki M.
    • Journal Title

      Evid Based Complement Alternat Med

      Volume: 2012 Pages: 862743-862743

    • DOI

      10.1155/2012/862743

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Chemical constitutes with anti-allergic activity from red peony root2015

    • Author(s)
      石燕紅,朱シュウ,数馬恒平,田村隆幸,小松かつ子
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      デザイン・クリエイティブセンター神戸(神戸)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Gentiana 属生薬の基原と品質に関する研究(5) - HPLC profile guided isolation and comparative study of constituents from gentian and relative Gentiana herbs2015

    • Author(s)
      何毓敏,朱シュウ,葛躍偉,呉暁テイ,小松かつ子
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      デザイン・クリエイティブセンター神戸(神戸)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] LC-MSによる大黄の縮合タンニン類の分析2015

    • Author(s)
      数馬恒平,葛躍偉,紺野勝弘,小松かつ子
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      デザイン・クリエイティブセンター神戸(神戸)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Development of branded herbal drugs on the basis of analytical results on genetic and chemical diversity of medicinal plants2014

    • Author(s)
      Komatsu K.
    • Organizer
      The 14th International Symposium on Traditional Medicine in Toyama (2014)
    • Place of Presentation
      富山国際会議場(富山)
    • Year and Date
      2014-10-27 – 2014-10-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Genetic and chemical characterization of white and red peony root derived from Paeonia lactiflora2014

    • Author(s)
      Zhu S., Yu X. L., Komatsu K.
    • Organizer
      The 28th International Symposium on the Chemistry of Natural Products and the 8th International Conference on Biodiversity
    • Place of Presentation
      Shanghai (China)
    • Year and Date
      2014-10-19 – 2014-10-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Gentiana 属生薬の基原と品質に関する研究(3)―Gentiana 属8種及び秦ギョウのITS配列について2014

    • Author(s)
      呉暁テイ,朱シュウ,合田幸広,小松かつ子
    • Organizer
      日本生薬学会第61回年会
    • Place of Presentation
      福岡大学薬学部(福岡)
    • Year and Date
      2014-09-13 – 2014-09-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Comparing the contents of main components in the roots of Bonten, a medicinal cultivar of Paeonia lactiflora after different post-harvest processing2014

    • Author(s)
      Zhu S., Shirakawa A., Shi Y. H., Yu X. L., Tamura T., Yoshimatsu K., Komatsu K.
    • Organizer
      The 8th JSP-CCTCNM-KSP Joint Symposium on Pharmacognosy
    • Place of Presentation
      福岡大学薬学部(福岡)
    • Year and Date
      2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Comprehensive Analysis of Sequencing Proanthocyanidin Oligomers in Rhubarb by HPLC-ESI-MS-MS2014

    • Author(s)
      Ge Y. W., Kazuma K., Zhu S., Yoshimatsu K., Komatsu K.
    • Organizer
      The 8th JSP-CCTCNM-KSP Joint Symposium on Pharmacognosy
    • Place of Presentation
      福岡大学薬学部(福岡)
    • Year and Date
      2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Genetic and chemical diversity of Gentiana plants and drugs (4) - Isolation of constituents with anti-inflammatory activity from Gentianae Macrophyllae Radix2014

    • Author(s)
      He Y. M., Zhu S., Wu X. T., Ge Y. W., Komatsu K.
    • Organizer
      The 8th JSP-CCTCNM-KSP Joint Symposium on Pharmacognosy
    • Place of Presentation
      福岡大学薬学部(福岡)
    • Year and Date
      2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Chemical constituents analysis of the leaf of Eleutherococcus senticosus cultivated in different environment2014

    • Author(s)
      葛躍偉,村上守一,田村隆幸,川本元裕,磯田進,朱シュウ,吉松嘉代,小松かつ子
    • Organizer
      第31回和漢医薬学会学術大会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2014-08-30 – 2014-08-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Gentiana属生薬の基原と品質に関する研究(2)-Gentiana属4種及び竜胆のITS配列について2014

    • Author(s)
      呉暁テイ,朱シュウ,于暁麗,合田幸広,小松かつ子
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] Gentiana属生薬の基原と品質に関する研究(1)-New secoiridoids from Gentianae Scabrae Radix2014

    • Author(s)
      何毓敏,朱シュウ,呉暁テイ,小松かつ子
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] プエラリン代謝反応における酵素反応中間体の同定2014

    • Author(s)
      中村賢一,竜瀬真衣,渥美志保,小松かつ子,服部征雄,岩島誠
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] Improvement of memory function by traditional medicine in Alzheimer’s disease model mice2014

    • Author(s)
      東田千尋
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 伝統医薬データベースを基盤とした難治性疾患への治療戦略2013

    • Author(s)
      小松かつ子
    • Organizer
      シンポジウム-「生薬等医薬資源の科学の構築」に向けて-
    • Place of Presentation
      東京大学(東京)(招待講演)
    • Year and Date
      2013-02-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] Chemical evaluation on Codonopsis Radix (1) - Development of HPLC-DAD method for analysis of polyacetylenes, phenylpropanoids and pyrrolidine alkaloids in medicinally-used Codonopsis species2013

    • Author(s)
      何敬愉,朱シュウ,小松かつ子
    • Organizer
      第30回和漢医薬学会学術大会
    • Place of Presentation
      金沢
    • Related Report
      2013 Annual Research Report
  • [Presentation] 腸内細菌由来プエラリンC‐配糖体代謝酵素の活性化に関与する低分子補因子の同定2013

    • Author(s)
      中村賢一,鈴華佳,竜瀬真衣,岡嵜萌里,渥美志保,小松かつ子,服部征雄,岩島誠
    • Organizer
      第30回和漢医薬学会学術大会
    • Place of Presentation
      金沢
    • Related Report
      2013 Annual Research Report
  • [Presentation] イメージング質量分析を用いたダイオウの二次代謝産物の組織内分布2013

    • Author(s)
      平修,朱シュウ,小松かつ子,磯田進,吉松嘉代
    • Organizer
      第30回和漢医薬学会学術大会
    • Place of Presentation
      金沢
    • Related Report
      2013 Annual Research Report
  • [Presentation] ダイオウの圃場栽培と優良系統の選抜2013

    • Author(s)
      小松かつ子,冷正鵬,白イェン晶,朱シュウ,葛躍偉, 伏見裕利, 村上守一,田村隆幸,中曽根亨,吉松嘉代
    • Organizer
      日本生薬学会第60回年会
    • Place of Presentation
      北海道当別
    • Related Report
      2013 Annual Research Report
  • [Presentation] Quality evaluation of medicinally used Codonopsis species and Codonopsis Radix based on the contents of pyrrolidine alkaloids, phenylpropanoid and polyacetylenes2013

    • Author(s)
      何敬愉,朱シュウ,小松かつ子,合田幸広,蔡少青
    • Organizer
      日本生薬学会第60回年会
    • Place of Presentation
      北海道当別
    • Related Report
      2013 Annual Research Report
  • [Presentation] カンゾウの品質評価に向けたメタボローム解析の活用2013

    • Author(s)
      原田和生,小田知佳,角明香里,高上馬希重,朱シュウ,小松かつ子,山本 豊,平田收正
    • Organizer
      日本生薬学会第60回年会
    • Place of Presentation
      北海道当別
    • Related Report
      2013 Annual Research Report
  • [Presentation] サステイナブル伝統薬を志向した薬用資源植物の多様性の解析2013

    • Author(s)
      小松かつ子
    • Organizer
      (財)染色体学会第64回年会
    • Place of Presentation
      富山
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Ashwagandha成分Sominoneの誘導体Denosominのアストロサイトを介した脊髄損傷改善作用2013

    • Author(s)
      執行美智子,久保山友晴,東田千尋
    • Organizer
      第30回和漢医薬学会学術大会
    • Place of Presentation
      金沢
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脊髄損傷の運動機能改善効果を持つ漢方生薬の研究2013

    • Author(s)
      田辺紀生,久保山友晴,数馬恒平,紺野勝弘,東田千尋
    • Organizer
      第30回和漢医薬学会学術大会
    • Place of Presentation
      金沢
    • Related Report
      2013 Annual Research Report
  • [Presentation] 加味帰脾湯のtauリン酸化持続抑制によるアルツハイマー病改善作用2013

    • Author(s)
      渡り英俊,嶋田豊,東田千尋
    • Organizer
      第30回和漢医薬学会学術大会
    • Place of Presentation
      金沢
    • Related Report
      2013 Annual Research Report
  • [Presentation] Diosgenin is an exogenous activator of 1,25D3-MARRS (Pdia3/ERp57) and improves memory dysfunction and axonal degeneration in Alzheimer’s disease model 5XFAD mice2013

    • Author(s)
      Tohda C., Urano T., Umezaki M., Kuboyama T.
    • Organizer
      Neuro 2013
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] A novel compound, Denosomin, promotes axonal growth via astrocytes secreting vimentin after spinal cord injury2013

    • Author(s)
      Shigyo M., Teshigawara K., Kuboyama T., Nagata A., Sugimoto K., Matsuya Y., Tohda C.
    • Organizer
      Neuro 2013
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Endocytosis-mediated axonal growth cone degeneration induced by amyloid β2013

    • Author(s)
      Kuboyama T., Nishiko H., Tohda C.
    • Organizer
      Neuro 2013
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Investigation of crude drugs effective for spinal cord injured mice2013

    • Author(s)
      Tanabe N., Kuboyama T., Miyanaga S., Kazuma K., Konno K., Tohda C.
    • Organizer
      Neuro 2013
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 食物アレルギー病態モデルにおける葛根湯の有効性とその免疫学的作用機序2013

    • Author(s)
      門脇真
    • Organizer
      第63回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Genetic characterization of White/Red Peony roots and the horticultural cultivars of Paeonia lactiflora by nuclear rDNA ITS sequences2013

    • Author(s)
      朱妹,于暁麗,白石史遠,小松かつ子,村上守一,田村隆幸
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 芍薬の成分的多様性の解析(2)一白芍・赤芍の成分的差異と園芸品種の薬用資源としての可能性2013

    • Author(s)
      干暁麗,朱妹,呉〓秋,小松かつ子,村上守一,田村隆幸
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 伝統薬物をベースとしたアカデミア創薬2013

    • Author(s)
      東田千尋
    • Organizer
      第3回和漢研・がん研ジョイントセミナー「アカデミア創薬の心・技・体」
    • Place of Presentation
      金沢エクセルホテル東急(金沢)(招待講演)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Diosgeninによるアルツハイマー病モデルマウスの記憶改善作用とその分子メカニズム2013

    • Author(s)
      東田千尋
    • Organizer
      第3回和漢研・長崎熱帯研ジョイントセミナー
    • Place of Presentation
      長崎大学(長崎)(招待講演)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Quality evaluation of Siberian Ginseng based on genetic polymorphism, chemical composition and protective activity against neurodegeneration2012

    • Author(s)
      Zhu S.
    • Organizer
      The 1st INM-NPRI Joint Symposium
    • Place of Presentation
      富山大学民族薬物資料館(富山)(招待講演)
    • Year and Date
      2012-12-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] Genetic and chemical characterization of white/red peony roots and the horticultural cultivars of paeonia lactiflora2012

    • Author(s)
      Zhu S.
    • Organizer
      The 5th International Symposium on Scientific Research of Traditional Medicine
    • Place of Presentation
      名鉄トヤマホテル(富山)(招待講演)
    • Year and Date
      2012-10-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] Natural medicine study aiming to explore therapeutic strategies for neurodegenerative diseases2012

    • Author(s)
      Tohda C.
    • Organizer
      International Symposium on Biomedicine and Drug-Development. Nanotechnology : from Bench to Enduser
    • Place of Presentation
      Basel, Switzerland(招待講演)
    • Year and Date
      2012-09-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] Natural medicine study aiming to explore therapeutic strategies for neurodegenerative diseases.2012

    • Author(s)
      Tohda C.
    • Organizer
      21st Symposium on Dementia
    • Place of Presentation
      Seoul, Korea(招待講演)
    • Year and Date
      2012-04-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] Genetic characterization of White/Red Peony roots and the horticultural varieties of Paeonia lactiflora2012

    • Author(s)
      Zhu S., Yu x. L., Shiraishi F., Komatsu K., Murakami M., Tamura T.
    • Organizer
      The 7th KSP-JSP-CCTCNM Joint Symposium on Pharmacognosy
    • Place of Presentation
      Mayfield Hotel(Seoul, Korea)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Medicinal properties of Ephedra and Glycyrrhiza plants in Mongolia2012

    • Author(s)
      Komatsu K.
    • Organizer
      Medicinal Plant and Natural Product Research- Traditional and Modern Aspects -International Symposium
    • Place of Presentation
      National University of Mongolia(Ulaanbaatar, Mongolia)(招待講演)
    • Related Report
      2012 Annual Research Report
  • [Presentation] アルツハイマー病マウスを用いたEleutheroside B及びEleutheroside Eの記憶改善効果の検討2012

    • Author(s)
      松永智子,東田千尋,白〓晶,朱妹,小松かつ子
    • Organizer
      第29回和漢医薬学会学術大会
    • Place of Presentation
      北里大学薬学部(東京)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Genetic and phytochemical analysis of Acanthopanacis Cortex2012

    • Author(s)
      Bai Y. J., Zhu S., He J. Y, 小松かつ子
    • Organizer
      日本生薬学会第59回年会
    • Place of Presentation
      かずさアカデミアパーク(千葉)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 薬用Acorus属植物の遺伝的・成分的多様性の解析2012

    • Author(s)
      小松かつ子, Bai Y. J., He Y. M., Zhu S., 合田幸広
    • Organizer
      日本生薬学会第59回年会
    • Place of Presentation
      かずさアカデミアパーク(千葉)
    • Related Report
      2012 Annual Research Report
  • [Presentation] A novel compound, Denosomin induces vimentin-secretion from astrocytes, resulting in promotion of axon elongation2012

    • Author(s)
      Kuboyama T., Teshigawara K., Shigyo M., Sugimoto K., Matsuya Y., Tohda C.
    • Organizer
      Neuroscience 2012
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Diosgenin is an exogenous activator of 1,25D3-MARRS (Pdia3/ERp57) and improves memory dysfunction and axonal degeneration in Alzheimer's disease model 5XFAD mice2012

    • Author(s)
      Tohda C., Urano T., Umezaki M., Nemere I., Kuboyama T.
    • Organizer
      Neuroscience 2012
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Denosomin improves SCI via axonal growth by increasing astrocyte-secreted Vimentin2012

    • Author(s)
      Shigyo M., Kuboyama T., Teshigawara K., Sugimoto K., Matsuya Y., Tohda C.
    • Organizer
      Neuroscience 2012
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] 腸管免疫性疾患に対する和漢薬からのアプローチ2012

    • Author(s)
      門脇真
    • Organizer
      第15回天然薬物研究方法論アカデミー
    • Place of Presentation
      クロス・ウェーブ船橋(千葉)(招待講演)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 紫雲膏の主要活性成分シコニンの核内オーファン受容体NR4Aの遺伝子発現抑制を介したマスト細胞に対する作用2012

    • Author(s)
      王暁宇,林周作,山本武,門脇真
    • Organizer
      第29回和漢医薬学会学術大会
    • Place of Presentation
      北里大学薬学部(東京)
    • Related Report
      2012 Annual Research Report
  • [Presentation] カンゾウの品質評価に向けたメタボローム解析の活用

    • Author(s)
      原田和生,小田知佳,角明香里,高上馬希重,山本豊,朱シュウ,小松かつ子,平田收正
    • Organizer
      第6回甘草に関するシンポジウム
    • Place of Presentation
      北海道当別
    • Related Report
      2013 Annual Research Report
  • [Presentation] ムラサキの生化学研究,特にシコニンの抗アレルギー作用の分子作用機序の研究

    • Author(s)
      門脇真
    • Organizer
      第1回ムラサキに関するシンポジウム
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 薬用植物・生薬の最前線-国内栽培技術から品質評価, 製品開発まで-(第4編第1章生薬の多様性解析と標準化)2014

    • Author(s)
      川原信夫監修,小松かつ子,朱シュウ 等著
    • Total Pages
      269
    • Publisher
      シーエムシー出版
    • Related Report
      2014 Annual Research Report
  • [Book] 和英対訳日本薬局方外生薬規格20122013

    • Author(s)
      局外生規2012出版検討会編集(小松かつ子分担)
    • Total Pages
      287
    • Publisher
      薬事日報社
    • Related Report
      2013 Annual Research Report
  • [Remarks] 富山大学和漢医薬学総合研究所生薬資源科学分野

    • URL

      http://www.inm.u-toyama.ac.jp/pharmacognosy/index-j.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 富山大学和漢医薬学総合研究所部門・分野紹介

    • URL

      http://www.inm.u-toyama.ac.jp/jp/departments/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 富山大学和漢医薬学総合研究所生薬資源科学分野

    • URL

      http://www.inm.u-toyama.ac.jp/pharmacognosy/index-j.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 富山大学和漢医薬学総合研究所生薬資源科学分野業績

    • URL

      http://www.inm.u-toyama.ac.jp/jp/departments/01_pharmacognosy_op.html

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.inm.u-toyama.ac.jp/pharmacognosy/index-j.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.inm.u-toyama.ac.jp/jp/departments/01_pharmacognosy.html

    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] アルツハイマー病の治療薬と治療2013

    • Inventor(s)
      東田千尋
    • Industrial Property Rights Holder
      東田千尋
    • Industrial Property Number
      2013-008136
    • Filing Date
      2013-01-21
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2012-04-24   Modified: 2019-07-29  

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