| Project/Area Number |
24406012
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 海外学術 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Nagasaki University |
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Principal Investigator |
KANEKO Osamu 長崎大学, 熱帯医学研究所, 教授 (50325370)
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| Co-Investigator(Renkei-kenkyūsha) |
YAHATA Kazuhide 長崎大学, 熱帯医学研究所, 助教 (40467965)
TSUBOI Takafumi 愛媛大学, プロテオサイエンスセンター, 教授 (00188616)
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| Research Collaborator |
ASADA Masahito 長崎大学, 熱帯医学研究所, 助教
SUNGKAPONG Tippawan タイ王国・ナレスワン大学, 健康科学部, 助手
HAN Eun-Taek 大韓民国・江原大学, 医学部, 教授
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | 感染症 / マラリア / 血清疫学 / 原虫 / 抗原 / 寄生虫 / 多型 |
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| Outline of Final Research Achievements |
Plasmodium vivax expresses several hundreds of proteins on the infected erythrocyte surface, such as VIR protein family, which is proposed to be responsible for the disease severity. However, humoral immunity against these antigens were not understood well. In this study, we examined antibody responses against a panel of VIR. Recombinant proteins were produced for 4 types of VIR (VirA, VirC, VirF, and Vir18) as well as the extracellular cysteine-rich domain of PvSTP2 (PvSTP2-CRD) and 19-kD region of merozoite surface protein 1 (PvMSP1-19kD). Plasma collected from Vivax patients in Southeast Asia were analyzed. The reactivity against all recombinant VIR was much lower than the PvMSP1-19kD. The reactivity pattern is similar between VirC and VirF, and between PvSTP2 and VirA, suggesting that they induce host response independently as groups. No correlation between antibody titre/reactivity against VIR and fever/parasitemia was observed.
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