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Molecular Epidemiological Studies of Helicobacter pylori in Southeastern Asia: Search for novel virulence factors and clarification of human migration

Research Project

Project/Area Number 24406015
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section海外学術
Research Field Bacteriology (including Mycology)
Research InstitutionOita University

Principal Investigator

YAMAOKA YOSHIO  大分大学, 医学部, 教授 (00544248)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywordsヘリコバクター・ピロリ / 疫学研究 / 内視鏡検査 / インドネシア / カンボジア / バングラディシュ / ブータン / ミャンマー / ベトナム / タイ / モンゴル / 分子疫学 / 胃癌 / 東南アジア / 細菌
Outline of Final Research Achievements

The aims of this project were 1) evaluation of the gastric cancer risk caused by Helicobacter pylori infection and 2) clarification of human migration patterns among Asian population using H. pylori genome. During the periods of the projects, I could collaborate with researchers in Indonesia, Vietnam, Nepal, Thailand, Myanmar, Mongolia, Bhutan, Bangladesh and Cambodia. I went to these countries, performed gastroduodenal endoscopy and we could succeed to culture H. pylori. In addition, procedure of endoscopy and the eradication therapy were done with free of charge to make a social contribution in their countries. In the genomic analyses, we obtained many novel findings including the discovery of novel H. pylori genotypes in a minor group in Vietnam.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (94 results)

All 2015 2014 2013 2012 Other

All Journal Article (52 results) (of which Peer Reviewed: 38 results,  Open Access: 9 results,  Acknowledgement Compliant: 14 results) Presentation (38 results) (of which Invited: 22 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Prevalence of Helicobacter pylori infection and atrophic gastritis in patients with dyspeptic symptoms in Myanmar2015

    • Author(s)
      Myint T, Shiota S, Vilaichone RK, Ni N, Aye TT, Matsuda M, Tran TT, Uchida T, Mahachai V, Yamaoka Y.
    • Journal Title

      World J Gastroenterol

      Volume: 21 Issue: 2 Pages: 629-636

    • DOI

      10.3748/wjg.v21.i2.629

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Differences in interleukin 8 expression in Helicobacter pylori-infected gastric mucosa tissues from patients in Bhutan and the Dominican Republic2015

    • Author(s)
      Nagashima H, Iwatani S, Cruz M, Jiménez Abreu JA, Tronilo L, Rodríguez E, Disla M, Terao H, Uchida T, Mahachai V, Vilaichone RK, Tshering L, Mitsui T, Shiota S, Graham DY, Yamaoka Y
    • Journal Title

      Hum Pathol

      Volume: 46 Issue: 1 Pages: 129-136

    • DOI

      10.1016/j.humpath.2014.10.006

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Search for novel candidate mutations for metronidazole resistance in Helicobacter pylori using next-generation sequencing2014

    • Author(s)
      Binh TT, Suzuki R, Trang TT, Kwon DH, Yamaoka Y
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 59 Issue: 4 Pages: 2343-2348

    • DOI

      10.1128/aac.04852-14

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Biomarkers for Helicobacter pylori infection and gastroduodenal diseases.2014

    • Author(s)
      Shiota S, Yamaoka Y
    • Journal Title

      Biomark Med

      Volume: 8 Issue: 9 Pages: 1127-1137

    • DOI

      10.2217/bmm.14.72

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Extremely low Helicobacter pylori prevalence in North Sulawesi, Indonesia and identification of a Maori-tribe type strain: a cross sectional study2014

    • Author(s)
      Miftahussurur M, Tuda J, Suzuki R, Kido Y, Kawamoto F, Matsuda M, Tantular IS, Pusarawati S, Nasronudin, Harijanto PN, Yamaoka Y
    • Journal Title

      Gut Pathog

      Volume: 6 Issue: 1

    • DOI

      10.1186/s13099-014-0042-0

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Genetic battle between Helicobacter pylori and humans. The mechanism underlying homologous recombination in bacteria, which can infect human cells.2014

    • Author(s)
      Hanada K, Yamaoka Y
    • Journal Title

      Microbes Infect

      Volume: 16 Issue: 10 Pages: 833-839

    • DOI

      10.1016/j.micinf.2014.08.001

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Helicobacter pylori from gastric cancer and duodenal ulcer show same phylogeographic origin in the Andean region in Colombia.2014

    • Author(s)
      Shiota S, Suzuki R, Matsuo Y, Miftahussurur M, Tran TT, Binh TT, Yamaoka Y
    • Journal Title

      PLoS One

      Volume: 9 Issue: 8 Pages: e105392-e105392

    • DOI

      10.1371/journal.pone.0105392

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of the genes that contribute to lactate utilization in Helicobacter pylori.2014

    • Author(s)
      Iwatani S, Nagashima H, Reddy R, Shiota S, Graham DY, Yamaoka Y
    • Journal Title

      PLoS One

      Volume: 9 Issue: 7 Pages: 103506-103506

    • DOI

      10.1371/journal.pone.0103506

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Helicobacter pylori infection introduces DNA double-strand breaks in host cells2014

    • Author(s)
      Hanada K, Uchida T, Tsukamoto Y, Watada M, Yamaguchi N, Yamamoto K, Shiota S, Moriyama M, Graham DY, Yamaoka Y
    • Journal Title

      Infect Immun.

      Volume: 82 Issue: 10 Pages: 4182-4189

    • DOI

      10.1128/iai.02368-14

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Helicobacter pylori virulence and cancer pathogenesis.2014

    • Author(s)
      Yamaoka Y, Graham DY
    • Journal Title

      Future Oncol.

      Volume: 10 Issue: 8 Pages: 1487-1500

    • DOI

      10.2217/fon.14.29

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Identification of Helicobacter pylori infection in symptomatic patients in Surabaya, Indonesia, using five diagnostic tests2014

    • Author(s)
      Miftahussurur M, Shiota S, Suzuki R, Matsuda M, Uchida T, Kido Y, Kawamoto F, Maimunah U, Adi P, Rezkitha Y, Nasronudin, Nusi I, Yamaoka Y
    • Journal Title

      Epidemiol Infect.

      Volume: 143 Issue: 5 Pages: 986-996

    • DOI

      10.1017/s095026881400154x

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Virulence genes of Helicobacter pylori in the Dominican Republic2014

    • Author(s)
      Shiota S, Cruz M, Abreu JA, Mitsui T, Terao H, Disla M, Iwatani S, Nagashima H, Matsuda M, Uchida T, Tronilo L, Rodríguez E, Yamaoka Y
    • Journal Title

      J Med Microbiol

      Volume: 63 Issue: 9 Pages: 1189-1196

    • DOI

      10.1099/jmm.0.075275-0

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Complete Genome Sequences of Eight Helicobacter pylori Strains with Different Virulence Factor Genotypes and Methylation Profiles, Isolated from Patients with Diverse Gastrointestinal Diseases on Okinawa Island, Japan, Determined Using PacBio Single-Molecule Real-Time Technology2014

    • Author(s)
      Satou K, Shiroma A, Teruya K, Shimoji M, Nakano K, Juan A, Tamotsu H, Terabayashi Y, Aoyama M, Teruya M, Suzuki R, Matsuda M, Sekine A, Kinjo N, Kinjo F, Yamaoka Y, Hirano T
    • Journal Title

      Genome Announc

      Volume: 2 Issue: 2

    • DOI

      10.1128/genomea.00286-14

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Discovery of novel mutations for clarithromycin resistance in Helicobacter pylori by using next-generation sequencing2014

    • Author(s)
      Binh TT, Shiota S, Suzuki R, Matsuda M, Trang TT, Kwon DH, Iwatani S, Yamaoka Y
    • Journal Title

      J Antimicrob Chemother

      Volume: 69 Issue: 7 Pages: 1796-1803

    • DOI

      10.1093/jac/dku050

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Strategy for the treatment of Helicobacter pylori infection2014

    • Author(s)
      Shiota S, Yamaoka Y
    • Journal Title

      Curr Pharm Des

      Volume: 20 Pages: 4489-4500

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] ヘリコバクター・ピロリとは何もの ー病原性の歴史も含めてー2014

    • Author(s)
      山岡 吉生
    • Journal Title

      化学療法の領域

      Volume: 30 Pages: 30-38

    • Related Report
      2014 Annual Research Report
  • [Journal Article] ヘリコバクター・ピロリの病原因子と分子疫学に関する研究2014

    • Author(s)
      山岡 吉生
    • Journal Title

      化学療法の領域

      Volume: 30 Pages: 100-107

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Helicobacter pylori 感染症の疫学と感染経路2014

    • Author(s)
      永島裕之、手島理絵、山岡 吉生
    • Journal Title

      Helicobacter Research

      Volume: 18 Pages: 28-31

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Detection of genotypic clarithromycin-resistant Helicobacter pylori by string tests2014

    • Author(s)
      Wu JY, Wang SS, Lee YC, Yamaoka Y, Graham DY, Jan CM, Wang WM, Wu DC
    • Journal Title

      World J Gastroenterol

      Volume: 20 Issue: 12 Pages: 3343-3349

    • DOI

      10.3748/wjg.v20.i12.3343

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discovery of novel mutations for clarithromycin resistance in Helicobacter pylori by using next-generation sequencing2014

    • Author(s)
      Binh TT, Shiota S, Suzuki R, Matsuda M, Trang TT, Kwon DH, Iwatani S, Yamaoka Y.
    • Journal Title

      J Antimicrob Chemother

      Volume: 未定

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum Helicobacter pylori CagA antibody titer as a useful marker for advanced inflammation in the stomach in Japan2014

    • Author(s)
      Shiota S, Murakami K, Okimoto T, Kodama M, Yamaoka Y
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 29 Issue: 1 Pages: 67-73

    • DOI

      10.1111/jgh.12359

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Complete Genome Sequences of Helicobacter pylori Clarithromycin-Resistant Strains2014

    • Author(s)
      Binh TT, Suzuki R, Shiota S, Kwon DH, Yamaoka Y
    • Journal Title

      Genome Announc.

      Volume: 1 Issue: 6

    • DOI

      10.1128/genomea.00912-13

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Strategy for the Treatment of Helicobacter pylori Infection2014

    • Author(s)
      Shiota S, Yamaoka Y
    • Journal Title

      Curr Pharm Des

      Volume: 未定

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CagA-dependent downregulation of B7-H2 expression on gastric mucosa and inhibition of Th17 responses during Helicobacter pylori infection2013

    • Author(s)
      Lina TT, Pinchuk IV, House J, Yamaoka Y, Graham DY, Beswick EJ, Reyes VE
    • Journal Title

      J Immunol

      Volume: 191 Issue: 7 Pages: 3838-3846

    • DOI

      10.4049/jimmunol.1300524

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Seroprevalence of Helicobacter pylori infection and gastric mucosal atrophy in Bhutan, a country with a high prevalence of gastric cancer2013

    • Author(s)
      Shiota S, Mahachai V, Vilaichone RK, Ratanachu-ek T, Tshering L, Uchida T, Matsunari O, Yamaoka Y
    • Journal Title

      J Med Microbiol

      Volume: 62 Issue: 10 Pages: 1571-1578

    • DOI

      10.1099/jmm.0.060905-0

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diversity of Helicobacter pylori genotypes in Iranian patients with different gastroduodenal disorders2013

    • Author(s)
      Vaziri F, Najar Peerayeh S, Alebouyeh M, Mirzaei T, Yamaoka Y, Molaei M, Maghsoudi N, Zali MR.
    • Journal Title

      World J Gastroenterol

      Volume: 19 Issue: 34 Pages: 5685-5692

    • DOI

      10.3748/wjg.v19.i34.5685

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antibiotics resistance rate of Helicobacter pylori in Bhutan2013

    • Author(s)
      Vilaichone RK, Yamaoka Y, Shiota S, Ratanachu-ek T, Tshering L, Uchida T, Fujioka T, Mahachai V
    • Journal Title

      World J Gastroenterol

      Volume: 19 Issue: 33 Pages: 5508-5512

    • DOI

      10.3748/wjg.v19.i33.5508

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of prehistoric human migration by Helicobacter pylori2013

    • Author(s)
      Suzuki R, Yamaoka Y
    • Journal Title

      Nihon Rinsho

      Volume: 71 Pages: 1368-1373

    • NAID

      40019751379

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The significance of virulence factors in Helicobacter pylori.2013

    • Author(s)
      Shiota S, Suzuki R, Yamaoka Y
    • Journal Title

      J Dig Dis

      Volume: Mar 1 Issue: 7 Pages: 341-349

    • DOI

      10.1111/1751-2980.12054

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extremely high prevalence of Helicobacter pylori infection in Bhutan2013

    • Author(s)
      Vilaichone RK, Mahachai V, Shiota S, Uchida T, Ratanachu-ek T, Tshering L, Tung NL, Fujioka T, Moriyama M, Yamaoka Y
    • Journal Title

      World J Gastroenterol

      Volume: 19 Issue: 18 Pages: 2806-2810

    • DOI

      10.3748/wjg.v19.i18.2806

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 現地に出向いてこその疫学研究2013

    • Author(s)
      山岡吉生
    • Journal Title

      日本ヘリコバクター学会誌

      Volume: 15 Pages: 38-44

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Helicobacter pyloriと胃癌2013

    • Author(s)
      山岡吉生
    • Journal Title

      臨床検査

      Volume: 57 Pages: 760-766

    • Related Report
      2013 Annual Research Report
  • [Journal Article] The incidence of primary antibiotic resistance of Helicobacter pylori in Vietnam2013

    • Author(s)
      Tran T Binh
    • Journal Title

      J Clin Gastroenterol

      Volume: 47 Issue: 3 Pages: 223-228

    • DOI

      10.1097/mcg.0b013e3182676e2b

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intact long-type dupA as a marker for gastroduodenal diseases in Okinawan subpopulation, Japan2013

    • Author(s)
      Ayaka Takahashi
    • Journal Title

      Helicobacter

      Volume: 18 Issue: 1 Pages: 66-72

    • DOI

      10.1111/j.1523-5378.2012.00994.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Helicobacter pylori cagA 12-bp insertion can be a marker for duodenal ulcer in Okinawa, Japan2013

    • Author(s)
      Yuji Matsuo
    • Journal Title

      J Gastroenterol Hepatol.

      Volume: 28 Issue: 2 Pages: 291-296

    • DOI

      10.1111/jgh.12067

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Helicobacter pylori infection in Japan2013

    • Author(s)
      Seiji Shiota
    • Journal Title

      Expert Rev Gastroenterol Hepatol.

      Volume: 7 Issue: 1 Pages: 35-40

    • DOI

      10.1586/egh.12.67

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 我々の厄介な相棒:ピロリ菌2013

    • Author(s)
      山岡吉生
    • Journal Title

      日本病態生理学会雑誌

      Volume: 21 Pages: 1-11

    • Related Report
      2012 Annual Research Report
  • [Journal Article] H. pylori感染率と感染経路2013

    • Author(s)
      塩田星児
    • Journal Title

      Helicobacter Research

      Volume: 17 Pages: 12-17

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Antibodies anti-CagA cross-react with trophoblast cells: a risk factor for pre-eclampsia?2012

    • Author(s)
      Francisco Franceschi
    • Journal Title

      Helicobacter

      Volume: 17 Issue: 6 Pages: 426-434

    • DOI

      10.1111/j.1523-5378.2012.00966.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Helicobacter pylori cagA EPIYA motif and vacA genotypes for the development of gastrointestinal diseases in Southeast Asian countries: a meta-analysis2012

    • Author(s)
      Shu Sahara
    • Journal Title

      BMC Infect Dis.

      Volume: 12 Issue: 1 Pages: 223-223

    • DOI

      10.1186/1471-2334-12-223

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In silico evolutionary analysis of Helicobacter pylori outer membrane phospholipase A (OMPLA).2012

    • Author(s)
      Hilde S Vollan
    • Journal Title

      BMC Microbiol.

      Volume: 12 Issue: 1 Pages: 206-206

    • DOI

      10.1186/1471-2180-12-206

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Helicobacter pylori-associated regulation of forkhead transcription factors FoxO1/3a in human gastric cells.2012

    • Author(s)
      Fazal H Tabassam
    • Journal Title

      Helicobacter

      Volume: 17 Issue: 3 Pages: 193-202

    • DOI

      10.1111/j.1523-5378.2012.00939.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strains2012

    • Author(s)
      Doreen Muller
    • Journal Title

      J Clin Invest

      Volume: 122 Issue: 4 Pages: 1553-1566

    • DOI

      10.1172/jci61143

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of Helicobacter pylori dupA With the Failure of Primary Eradication2012

    • Author(s)
      Shiota S, Nguyen LT, Murakami K, Kuroda A, Mizukami K. Okimoto T, Kodama M, Fujioka T, Yamaoka Y
    • Journal Title

      J Clin Gastroenterol

      Volume: 46(4) Issue: 4 Pages: 297-301

    • DOI

      10.1097/mcg.0b013e318243201c

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] H.pyloriゲノム解析と臨床2012

    • Author(s)
      山岡吉生
    • Journal Title

      日本ヘリコバクター学会誌

      Volume: 13 Pages: 23-24

    • Related Report
      2012 Annual Research Report
  • [Journal Article] ピロリ菌感染の分子疫学2012

    • Author(s)
      山岡吉生
    • Journal Title

      Gastro-Health Now

      Volume: 19 Pages: 1-3

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 欧米型CagAを有するHelicobacter pyloriの起源と疾患の関連性2012

    • Author(s)
      松成修
    • Journal Title

      消化器内科

      Volume: 54 Pages: 283-289

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 第2回Asian Pacific Topic Conference (APTC)-Asian Pacific HeIicobacter pylori Meeting 2012-2012

    • Author(s)
      松成修
    • Journal Title

      Helicobacter Research

      Volume: 16 Pages: 162-165

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 断片化したCagAタンパクは日本人患者において高い免疫応答を示す2012

    • Author(s)
      山岡吉生
    • Journal Title

      Helicobacter 日本語抄訳版

      Volume: 14 Pages: 8-11

    • Related Report
      2012 Annual Research Report
  • [Journal Article] ピロリ菌感染と健康長寿2012

    • Author(s)
      山岡吉生
    • Journal Title

      学術の動向

      Volume: 7 Pages: 32-38

    • NAID

      130002573743

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Helicobacter pyloriと花粉症2012

    • Author(s)
      今村重義
    • Journal Title

      成人病と生活習慣病

      Volume: 42 Pages: 1228-1231

    • Related Report
      2012 Annual Research Report
  • [Journal Article] H. pyloriにおけるCagA多型性と胃粘膜傷害の免疫組織学的検討2012

    • Author(s)
      児玉雅明
    • Journal Title

      日本消化器病学会雑誌

      Volume: 109 Pages: 37-46

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] The diversity of Helicobacter pylori: correlation to laboratory diagnosis2014

    • Author(s)
      Yamaoka Y
    • Organizer
      9th National Symposium & Workshop of Indonesia Antimicrobiol Resistance Watch and Annual Scientific Meeting of Indonesian Society for Clinical Microbiologist
    • Place of Presentation
      ジャカルタ(インドネシア)
    • Year and Date
      2014-11-29 – 2014-11-30
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Genomic diversity of Helicobacter pylori in Asia2014

    • Author(s)
      Yamaoka Y
    • Organizer
      Asian Pacific Digestive Week
    • Place of Presentation
      バリ島(インドネシア)
    • Year and Date
      2014-11-22 – 2014-11-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] CagAの差異で、胃癌の発症率の地域差を説明することは本当にできるのか?2014

    • Author(s)
      山岡吉生
    • Organizer
      日本ヘリコバクター学会
    • Place of Presentation
      ステーションカンファレンス東京(東京都千代田区)
    • Year and Date
      2014-06-28 – 2014-06-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Does the difference of CagA phenotype explain the geographic differences in gastric cancer incidence?2014

    • Author(s)
      Yamaoka Y
    • Organizer
      4th Mongolian Digestive Disease Week 2014
    • Place of Presentation
      ウランバートル(モンゴル)
    • Year and Date
      2014-06-18 – 2014-06-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Self-organizing mini-guts from a single intestinal stem cell: the organoids2014

    • Author(s)
      Yamaoka Y
    • Organizer
      4th Mongolian Digestive Disease Week 2014
    • Place of Presentation
      ウランバートル(モンゴル)
    • Year and Date
      2014-06-18 – 2014-06-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The relations of bacterial and host factors in Helicobacter pylori infected gastric mucosa2014

    • Author(s)
      Yamaoka Y, Cruz M, Disla M, Graham DY, Iwatani S, Jimenez JA, Nagashima H
    • Organizer
      X Congreso International de Investigacion Cientifica
    • Place of Presentation
      サントドミンゴ(ドミニカ共和国)
    • Year and Date
      2014-06-12 – 2014-06-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Molecular epidemiology and outcome of Helicobacter pylori in Laos2014

    • Author(s)
      Vannarath S, Vilaichone RK, Rasachak B, Mahachai V, Mairlang P, Yamaoka Y.
    • Organizer
      アメリカ消化器病学会
    • Place of Presentation
      シカゴ(米国)
    • Year and Date
      2014-05-03 – 2014-05-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] The relations of bacterial and host factors of IL-8 expression in Helicobacter pylori infected gastric mucosa2014

    • Author(s)
      Nagashima H, Iwatani S, Cruz M, Jimenez JA, Mahachai V, Vilaichone RK, Uchida T, Shiota S, Graham DY, Yamaoka Y
    • Organizer
      アメリカ消化器病学会
    • Place of Presentation
      シカゴ(米国)
    • Year and Date
      2014-05-03 – 2014-05-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Helicobacter pyloriのOuter membrane protein A (OipA)による病原性発現機構の分子基盤2014

    • Author(s)
      城戸康年、松尾祐一、山岡吉生
    • Organizer
      日本消化器病学会総会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2014-04-23 – 2014-04-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Human migration inferred by Helicobacter pylori genes2014

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      SOKENDAI Symposium: Modern human diversity on genes and culture
    • Place of Presentation
      総合大学院大学(神奈川県葉山町)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Medical education and international exchange program in Baylor College of Medicine2014

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      The 3rd Dong-A International Medical Symposium
    • Place of Presentation
      韓国(釜山市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Carcinogenesis of Helicobacter pylori infection2014

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      The 3rd Dong-A International Medical Symposium
    • Place of Presentation
      Dong-A大学(韓国釜山市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ピロリ菌の分子疫学2014

    • Author(s)
      山岡吉生
    • Organizer
      第15回九州予防医学研究会
    • Place of Presentation
      ビーコンプラザ(大分県別府市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Helicobacter pylori genomes: from pathogenesis to tool for human migration2014

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      The 87th Annual meeting of Japanese Society for Bacteriology
    • Place of Presentation
      タワーホール船堀(東京都江戸川区)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Molecular epidemiology of Helicobacter pylori : Association between Helicobacter pylori and disease outcomes2013

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      43th Annual Meeting of Gastroenterological Society of Taiwan
    • Place of Presentation
      高雄、台湾(招待講演)
    • Year and Date
      2013-03-16
    • Related Report
      2012 Annual Research Report
  • [Presentation] Molecular epidemiology of Helicobacter pylori2013

    • Author(s)
      山岡吉生
    • Organizer
      日本学術振興会アジア研究教育拠点事業セミナー
    • Place of Presentation
      神戸市、兵庫県(招待講演)
    • Year and Date
      2013-02-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] ピロリ菌による人類移動の歴史推定2013

    • Author(s)
      鈴木留美子
    • Organizer
      日本ヘリコバクター学会
    • Place of Presentation
      長崎大学(長崎県長崎市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Helicobacter pyloriと生体防御2013

    • Author(s)
      山岡吉生
    • Organizer
      第24回日本生体防除学会
    • Place of Presentation
      くまもと森都心プラザ(熊本県熊本市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Helicobacter pylori Current status in Dominican Republic 1st phase2013

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      XXII Congreso Nacional de Gastroenterologia
    • Place of Presentation
      ハードロックホテル(ドミニカ共和国プンタカナ市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Genetic characteristics of Helicobacter pylori and its relation to gastric cancer2013

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      XXII Congreso Nacional de Gastroenterologia
    • Place of Presentation
      ハードロックホテル(ドミニカ共和国プンタカナ市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] The Mongolian gerbil model2013

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      XXVIth International Workshop on Helicobacter pylori and related bacteria in chronic digestive inflammation and gastric cancer
    • Place of Presentation
      Facultad de Medicina de la Univeridad Autonoma(スペイン マドリッド市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Helicobacter pylori genotypes in Asian countries2013

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      XXVIth International Workshop on Helicobacter pylori and related bacteria in chronic digestive inflammation and gastric cancer
    • Place of Presentation
      Facultad de Medicina de la Univeridad Autonoma(スペイン マドリッド市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ピロリ菌と人類の共存がもたらしたこと2012

    • Author(s)
      山岡吉生
    • Organizer
      大分循環器研究会
    • Place of Presentation
      大分市、大分県(招待講演)
    • Year and Date
      2012-09-18
    • Related Report
      2012 Annual Research Report
  • [Presentation] A20 upregulation is induced by Helicobacter pylori induced in gastric epithelial Cells.2012

    • Author(s)
      Tomohisa Uchida
    • Organizer
      XXVth International Workshop of the European Helicobacter Study Group
    • Place of Presentation
      リュブジャナ、スロベニア
    • Year and Date
      2012-09-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] Helicobacter pylori typing as a tool for tracking human migration2012

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      International Congress of Physiological Anthropology
    • Place of Presentation
      北京、中国(招待講演)
    • Year and Date
      2012-09-03
    • Related Report
      2012 Annual Research Report
  • [Presentation] 我々のやっかいな相棒「ピロリ菌」2012

    • Author(s)
      山岡吉生
    • Organizer
      第22回日本病態生理学会大会
    • Place of Presentation
      由布市、大分県(招待講演)
    • Year and Date
      2012-08-05
    • Related Report
      2012 Annual Research Report
  • [Presentation] Geographic differences of Helicobacter pylori genotypes and gastric cancer2012

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      VIII Congreso International Interdisciplinario de Investigacion Cientifica
    • Place of Presentation
      サンドドミンゴ、ドニミカ共和国(招待講演)
    • Year and Date
      2012-06-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] Effect of irsogladine maleate on Interleukin-8 production caused by the Helicobacter pylori infection of gastric epithelial cells2012

    • Author(s)
      Osamu Matsunari
    • Organizer
      113th Annual Meeting of the American Gastroenterologicat Association
    • Place of Presentation
      サン・ディエゴ、USA
    • Year and Date
      2012-05-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] Association between serum Helicobacter pylori CagA antibody titer, pepsinogenin Japan2012

    • Author(s)
      Seiji Shiota
    • Organizer
      113th Annual Meeting of the American Gastroenterologicat Association
    • Place of Presentation
      サン・ディエゴ、USA
    • Year and Date
      2012-05-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] Novel candidate mutations for clarithromycin resistance of H. pylori.2012

    • Author(s)
      Tran T Binh
    • Organizer
      113th Annual Meeting of the American Gastroenterological Association
    • Place of Presentation
      サン・ディエゴ、USA
    • Year and Date
      2012-05-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] Association of Helicobacter pylori-related gastroduodenal diseases with vacA and cagA genotypes in Southeast Asia.2012

    • Author(s)
      Varocha Mahachai
    • Organizer
      113th Annual Meeting of the American Gastroenterologicat Association
    • Place of Presentation
      サン・ディエゴ、USA
    • Year and Date
      2012-05-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] ピロリ菌研究の面白さ;沖縄特有のピロリ菌の発見も含めて

    • Author(s)
      山岡吉生
    • Organizer
      第9回沖縄上部消化管の炎症を考える会
    • Place of Presentation
      ザ・ナハテラス(沖縄県那覇市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] アジア諸国におけるヘリコバクター・ピロリの遺伝子型:沖縄特異型を含めて

    • Author(s)
      山岡吉生
    • Organizer
      沖縄ゲノムを基盤とする知的・産業国際クラスターの形成い関する研究開発:国際シンポジウム
    • Place of Presentation
      パークホテル(沖縄県那覇市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ピロリ菌感染症の臨床と研究

    • Author(s)
      山岡吉生
    • Organizer
      第303回日本内科学会地方会 生涯教育講演会
    • Place of Presentation
      ロワジールホテル(沖縄県那覇市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Genotypes of Helicobacter pylori in Asian countries

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      Mongolia-Japan joint symposium for Helicobacter pylori
    • Place of Presentation
      モンゴル健康科学大学(モンゴル共和国ウランバートル)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ピロリ菌の分子疫学研究

    • Author(s)
      山岡吉生
    • Organizer
      挾間薬学セミナー
    • Place of Presentation
      大分大学(大分県由布市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Molecular epidemiological studies of Helicobacter pylori

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      Sentani Hospital Symposium
    • Place of Presentation
      センタニ病院(インドネシア共和国ジャヤプラ市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Helicobacter pylori and gastric cancer in Asia: from epidemiological view

    • Author(s)
      Yoshio Yamaoka
    • Organizer
      Seoul National University Gastroenterology Meeting
    • Place of Presentation
      ソウル国立大学(韓国ソウル市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 胃がんリスク検診(ABC検診)マニュアル:改正2版2015

    • Author(s)
      山岡 吉生
    • Total Pages
      3
    • Publisher
      南山堂
    • Related Report
      2014 Annual Research Report
  • [Remarks] 環境予防講座

    • URL

      http://www.med.oita-u.ac.jp/phealth2/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] http://www.med.oita-u.ac.jp/phealth2/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.oita-u.ac.jp/phealth2/index.html

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2012-04-24   Modified: 2019-07-29  

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