Molecular Epidemiological Studies of Helicobacter pylori in Southeastern Asia: Search for novel virulence factors and clarification of human migration
| Project/Area Number |
24406015
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 海外学術 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Oita University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | ヘリコバクター・ピロリ / 疫学研究 / 内視鏡検査 / インドネシア / カンボジア / バングラディシュ / ブータン / ミャンマー / ベトナム / タイ / モンゴル / 分子疫学 / 胃癌 / 東南アジア / 細菌 |
|---|
| Outline of Final Research Achievements |
The aims of this project were 1) evaluation of the gastric cancer risk caused by Helicobacter pylori infection and 2) clarification of human migration patterns among Asian population using H. pylori genome. During the periods of the projects, I could collaborate with researchers in Indonesia, Vietnam, Nepal, Thailand, Myanmar, Mongolia, Bhutan, Bangladesh and Cambodia. I went to these countries, performed gastroduodenal endoscopy and we could succeed to culture H. pylori. In addition, procedure of endoscopy and the eradication therapy were done with free of charge to make a social contribution in their countries. In the genomic analyses, we obtained many novel findings including the discovery of novel H. pylori genotypes in a minor group in Vietnam.
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Report
(4 results)
Research Products
(94 results)
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[Journal Article] Differences in interleukin 8 expression in Helicobacter pylori-infected gastric mucosa tissues from patients in Bhutan and the Dominican Republic2015
Author(s)
Nagashima H, Iwatani S, Cruz M, Jiménez Abreu JA, Tronilo L, Rodríguez E, Disla M, Terao H, Uchida T, Mahachai V, Vilaichone RK, Tshering L, Mitsui T, Shiota S, Graham DY, Yamaoka Y
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Journal Title
Hum Pathol
Volume: 46
Issue: 1
Pages: 129-136
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Extremely low Helicobacter pylori prevalence in North Sulawesi, Indonesia and identification of a Maori-tribe type strain: a cross sectional study2014
Author(s)
Miftahussurur M, Tuda J, Suzuki R, Kido Y, Kawamoto F, Matsuda M, Tantular IS, Pusarawati S, Nasronudin, Harijanto PN, Yamaoka Y
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Journal Title
Gut Pathog
Volume: 6
Issue: 1
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Identification of Helicobacter pylori infection in symptomatic patients in Surabaya, Indonesia, using five diagnostic tests2014
Author(s)
Miftahussurur M, Shiota S, Suzuki R, Matsuda M, Uchida T, Kido Y, Kawamoto F, Maimunah U, Adi P, Rezkitha Y, Nasronudin, Nusi I, Yamaoka Y
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Journal Title
Epidemiol Infect.
Volume: 143
Issue: 5
Pages: 986-996
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Virulence genes of Helicobacter pylori in the Dominican Republic2014
Author(s)
Shiota S, Cruz M, Abreu JA, Mitsui T, Terao H, Disla M, Iwatani S, Nagashima H, Matsuda M, Uchida T, Tronilo L, Rodríguez E, Yamaoka Y
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Journal Title
J Med Microbiol
Volume: 63
Issue: 9
Pages: 1189-1196
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Complete Genome Sequences of Eight Helicobacter pylori Strains with Different Virulence Factor Genotypes and Methylation Profiles, Isolated from Patients with Diverse Gastrointestinal Diseases on Okinawa Island, Japan, Determined Using PacBio Single-Molecule Real-Time Technology2014
Author(s)
Satou K, Shiroma A, Teruya K, Shimoji M, Nakano K, Juan A, Tamotsu H, Terabayashi Y, Aoyama M, Teruya M, Suzuki R, Matsuda M, Sekine A, Kinjo N, Kinjo F, Yamaoka Y, Hirano T
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Journal Title
Genome Announc
Volume: 2
Issue: 2
DOI
Related Report
Peer Reviewed / Open Access
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