Investigation on neurodegenerative effect of 1-bromopropane using new biomarkers
Project/Area Number |
24406018
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 海外学術 |
Research Field |
Hygiene
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Research Institution | Tokyo University of Science (2014) Nagoya University (2012-2013) |
Principal Investigator |
ICHIHARA Gaku 東京理科大学, 薬学部, 教授 (90252238)
|
Co-Investigator(Kenkyū-buntansha) |
WAKAI Kenji 名古屋大学, 医学系研究科, 教授 (50270989)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
|
Keywords | バイオマーカー / ブロモプロパン / 量反応関係 / 神経毒性 / 運動 / 振動覚 / 伝道速度 |
Outline of Final Research Achievements |
Protein adduct in globin formed by exposure to 1-bromopropane was quantified in 25 workers in a factory. The level of S-propyl cysteine in globin showed significant and negative association with the number of leucocyte. S-propyl cysteine might be useful as a biomarker for 1-bromopropane exposure.
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Report
(4 results)
Research Products
(135 results)
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[Journal Article] Copper oxide nanoparticles reduce vasculogenesis in transgenic zebrafish through down-regulation of VEGF expression and induction of apoptosis.2015
Author(s)
Chang J, Ichihara G, Shimada Y, Tada-Oikawa S, Kuroyanagi J, Zhang B, Suzuki Y, Sehsah R, Kato M, Tanaka T, Ichihara S.
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Journal Title
J Nanosci Nanotech
Volume: 印刷中
Related Report
Peer Reviewed
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[Journal Article] Dispersion method for safety research on manufactured nanomaterials.2014
Author(s)
Wu W, Ichihara G, Suzuki Y, Izuoka K, Oikawa-Tada S, Chang J, Sakai K, Miyazawa K, Porter D, Castranova V, Kawaguchi M, Ichihara S.
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Journal Title
Ind Health
Volume: 52
Pages: 54-65
NAID
Related Report
Peer Reviewed
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[Journal Article] Expression of proteins associated with adipocyte lipolysis was significantly changed in the adipose tissues of the obese spontaneously hypertensive/NDmcr-cp rat2014
Author(s)
Chang J, Oikawa S, Iwahashi H, Kitagawa E, Takeuchi I, Yuda M, Aoki C, Yamada Y, Ichihara G, Kato M, Ichihara S
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Journal Title
Diabetol Metab Syndr
Volume: 6(1)
Issue: 1
Pages: 8-8
DOI
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Peer Reviewed / Open Access
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[Journal Article] Synergistic effect of bolus exposure to zinc oxide nanoparticles on bleomycin-induced secretion of pro-fibrotic cytokines without lasting fibrotic changes in murine lungs.2014
Author(s)
Wu W, Ichihara G, Hashimoto N, Hasegawa Y, Hayashi Y, Tada-Oikawa S, Suzuki Y, Chang J, Kato M, D’Alessandro-Gabazza CN, Gabazza EC, Ichihara S.
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Journal Title
Int J Mol Sci
Volume: 16
Pages: 660-676
Related Report
Peer Reviewed / Open Access
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[Journal Article] Copper oxide nanoparticles reduce vasculogenesis in transgenic zebrafish through down-regulation of VEGF expression and induction of apoptosis.2014
Author(s)
Chang J, Ichihara G, Shimada Y, Tada-Oikawa S, Kuroyanagi J, Zhang B, Suzuki Y, Sehasah R, Kato M, Tanaka T, Ichihara S
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Journal Title
Journal of Nanoscience and Nanotechnology
Volume: in press
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[Journal Article] Comparison of Barium and Arsenic Concentrations in Well Drinking Water and in Human Body Samples and a Novel Remediation System for These Elements in Well Drinking Water.2013
Author(s)
Kato M, Kumasaka MY, Ohnuma S, Furuta A, Kato Y, Shekhar HU, Kojima M, Koike Y, Dinh Thang N, Ohgami N, Ly TB, Jia X, Yetti H, Naito H, Ichihara G, Yajima I.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Identification of a glutamic acid repeat polymorphism of ALMS1 as a novel genetic risk marker for early-onset myocardial infarction by genome-wide linkage analysis.2013
Author(s)
Ichihara S, Yamamoto K, Asano H, Nakatochi M, Sukegawa M, Ichihara G, Izawa H, Hirashiki A, Takatsu F, Umeda H, Iwase M, Inagaki H, Hirayama H, Sone T, Nishigaki K, Minatoguchi S, Cho MC, Jang Y, Kim HS, Yokota M. 他10名
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Journal Title
Circ Cardiovasc Genet
Volume: 6
Issue: 6
Pages: 569-578
DOI
Related Report
Peer Reviewed
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[Journal Article] Altered gene and protein expression in liver of the obese spontaneously hypertensive/NDmcr-cp rat.2012
Author(s)
Chang J, Oikawa S, Ichihara G, Nanpei Y, Hotta Y, Yamada Y, Tada-Oikawa S, Iwahashi H, Kitagawa E, Takeuchi I, Yuda M, Ichihara S.
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Journal Title
Nutr Metab (Lond).
Volume: 9(1)
Issue: 1
Pages: 87-87
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Exposure to 1-bromopropane induces microglial changes and oxidative stress in the rat cerebellum.2012
Author(s)
Subramanian K, Mohideen SS, Suzumura A, Asai N, Murakumo Y, Takahashi M, Jin S, Zhang L, Huang Z, Ichihara S, Kitoh J, Ichihara G.
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Journal Title
Toxicology.
Volume: 302(1)
Issue: 1
Pages: 18-24
DOI
Related Report
Peer Reviewed
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[Presentation] Establishment of mouse model for neurotoxicity of 1-bromopropane, an alternative to ozone-depleting solvents2015
Author(s)
Cai Zong, Edwin Garner, Chin-Yen Huang, Lingyi Zhang, Xiao Zhang, Shinya Toyokuni, Sahoko Ichihara, Gaku Ichihara,
Organizer
SOT 54th Annual Meeting
Place of Presentation
San Diego California, USA
Year and Date
2015-03-22 – 2015-03-26
Related Report
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[Presentation] Synergistic effect of exposure to zinc oxide nanoparticle on inflammatory response to bleomycin-induced pulmonary fibrosis in mice2014
Author(s)
Wenting Wu, Gaku Ichihara, Naozumi Hashimoto, Yoshinori Hasegawa, Yasuhiko Hayashi, Masashi Kato, Saeko Tada-Oikawa, Yuka Suzuki, Jie Chang1, Corina N. D'Alessandro-Gabazza, Esteban C. Gabazza, Sahoko Ichihara
Organizer
第41回日本毒性学会
Place of Presentation
神戸コンベンションセンター 神戸市
Year and Date
2014-07-02 – 2014-07-04
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[Presentation] Effects of Exposure to 1-Bromopropane on the Level of Thyroid Hormone in Cerebrospinal Fluid of Rats.2014
Author(s)
L. Zhang, C. Zong1, N. Koibuchi, S. Ichihara, H. Fujita, J. Chang, J. Huang, H. Naito, M. Kato, G. Ichihara
Organizer
The 53rd Annual Meeting of the Society of Toxicology
Place of Presentation
Phoenix Convention Center, AZ, USA
Related Report
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[Presentation] The Effects of Pharyngeal Aspiration-Exposure to Zinc Oxide Nanoparticles on Pulmonary Fibrosis Induced Bleomycin in Mice.2014
Author(s)
W. Wu, G. Ichihara, S. Tada-Oikawa, Y. Suzuki, J. Chang,N. Hashimoto, Y. Hasegawa, D. W. Porter, V. Castranova, C. Gabazza, E. Gabazza, S. Ichihara
Organizer
The 53rd Annual Meeting of the Society of Toxicology
Place of Presentation
Phoenix Convention Center, AZ, USA
Related Report
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[Presentation] The Effects of Metal Oxide Nanoparticles on Angiogenesis in Transgenic Zebrafish2014
Author(s)
J. Chang, G. Ichihara, Y. Shimada, S. Tada-Oikawa, Y. Suzuki, R. Sehsah, M. Kato, T. Tanaka, S. Ichihara
Organizer
The 53rd Annual Meeting of the Society of Toxicology
Place of Presentation
Phoenix Convention Center, AZ, USA
Related Report
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[Presentation] The Effect of Pharyngeal Aspiration Exposureto Zinc Oxide Nanoparticles on Pulmonary Fibrosis Induced by Bleomycin in Mice2013
Author(s)
Wu W,Gaku Ichihara,Saeko tada-Oikawa,Yuka Suzuki,Jie Chang,Naozumi Hashimoto,Yoshimori Hasegawa,Corina Gabazza,Esteban Gabazza and Sahoko Ichihara
Organizer
the XIII International Congress of Toxicology
Place of Presentation
Coex,Seoul,Korea
Related Report
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[Presentation] NanOEHS Overview2013
Author(s)
Gaku Ichihara, Yoshinori Hasegawa
Organizer
The 6th International Symposium on Nanotechnology, Occupational and Environmental Health; NanOEH6(第6回国際ナノテクノロジー労働環境衛生シンポジウム)
Place of Presentation
名古屋国際会議場、名古屋市
Related Report
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[Presentation] Effects on Respiratory and Cardiovascular Systems in Workers Handling Titanium Dioxide Particles2013
Author(s)
Sahoko Ichihara, Weihua Li, Seiichi Omura, Yuji Fujitani, Ying Liu, Qiangyi Wang, Yusuke Hiraku, Naomi Hisanaga, Xuncheng Ding, Takahiro Kobayashi, Gaku Ichihara
Organizer
The 6th International Symposium on Nanotechnology, Occupational and Environmental Health; NanOEH6(第6回国際ナノテクノロジー労働環境衛生シンポジウム)
Place of Presentation
名古屋国際会議場、名古屋市
Related Report
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[Presentation] Dispersion method for safety research on manufactured nanomaterials2013
Author(s)
Wenting Wu, Gaku Ichihara, Yuka Suzuki, Kiyora Izuoka, Saeko Oikawa-Tada, Jie Chang, Kiyoshi Sakai, Kun’ichi Miyazawa, Dale Porter, Vincent Castranova, Masami Kawaguchi , Sahoko Ichihara
Organizer
The 6th International Symposium on Nanotechnology, Occupational and Environmental Health; NanOEH6(第6回国際ナノテクノロジー労働環境衛生シンポジウム)
Place of Presentation
名古屋国際会議場、名古屋市
Related Report
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[Presentation] The effects of exposure to zinc oxide nanoparticles on bleomycin-induced pulmonary fibrosis in mice2013
Author(s)
Wenting Wu, Gaku Ichihara, Saeko Tada-Oikawa, Yuka Suzuki, Jie Chang, Naozumi Hashimoto, Yoshinori Hasegawa, Corina Gabazza, Esteban Gabazza, Sahoko Ichihara
Organizer
The 6th International Symposium on Nanotechnology, Occupational and Environmental Health; NanOEH6(第6回国際ナノテクノロジー労働環境衛生シンポジウム)
Place of Presentation
名古屋国際会議場、名古屋市
Related Report
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[Presentation] Involvement of Nrf-2 in ZnO NP-induced pulmonary inflammation2013
Author(s)
Radwa Ibrahim Sehsah, Wenting Wu, Sahoko Ichihara, Naozumi Hashimoto, Yoshinori Hasegawa, Ken Ito, Masayuki Yamamoto, Emily Kamel, Gaku Ichihara
Organizer
The 6th International Symposium on Nanotechnology, Occupational and Environmental Health; NanOEH6(第6回国際ナノテクノロジー労働環境衛生シンポジウム)
Place of Presentation
名古屋国際会議場、名古屋市
Related Report
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[Presentation] Effects of Short- and Long-Term Exposure to 1-Bromopropane on Neurogenesis in Adult Rats2013
Author(s)
L. Zhang, T. Nagai, K. Yamada, D.Ibi, S. Ichihara, K. Subramanian, Z. Huang, S. Sheik Mohideen, H. Naito, and G. Ichihara.
Organizer
The 52th Annual Meeting of the Society of Toxicology
Place of Presentation
SanAntonio, USA
Related Report
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[Presentation] Occupational and Environmental Health in Nanotechnology2012
Author(s)
Gaku Ichihara, Takahiro Kobayashi, Kunichi、Miyazawa, Naomi Hisanaga, Kiyoshi Sakai, Eiji Shibata, Ilje Yu, Shinya Toyokuni, Yoshinori Hasegawa, Sahoko Ichihara
Organizer
NANO KOREA 2012 symposium : The 10th International Nanotech Symposium
Place of Presentation
Coex, Seoul, Korea
Related Report
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[Presentation] Dispersion method for safety research on manufactured nanomaterials2012
Author(s)
Wenting Wu, Gaku Ichihara, Yuka Suzuki, Kiyora Izuoka, Saeko Oikawa-Tada, Jie Chang, Kiyoshi Sakai, Kunichi Miyazawa, Dale Porter, Vincet Castranova, Masami Kawaguchi, and Sahoko Ichihara
Organizer
The 6th International Conference on Nanotoxicology
Place of Presentation
20120904-20120907
Related Report
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[Presentation] Dispersion Method for Safety Researches on Manufactured Nanomaterials2012
Author(s)
Wenting Wu, Gaku Ichihara, Yuka Suzuki, Kiyora Izuoka, Saeko Oikawa-Tada, Jie Chang, Kiyoshi Sakai, Kunichi Miyazawa, Dale Porter, Vincet Castranova, Masami Kawaguchi, and Sahoko Ichihara
Organizer
IUMRS-ICEM2012
Place of Presentation
パシフィコ横浜(横浜市)
Related Report
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[Presentation] Dispersion method for safety research on manufactured nanomaterials2012
Author(s)
Wenting Wu, Gaku Ichihara, Yuka Suzuki, Kiyora Izuoka, Saeko Oikawa-Tada, Jie Chang, Kiyoshi Sakai, Kunichi Miyazawa, Dale Porter, Vincet Castranova, Masami Kawaguchi, and Sahoko Ichihara
Organizer
日本産業衛生学会第40回産業中毒・生物学的モニタリング研究会
Place of Presentation
マホロバマインズ三浦(神奈川県三浦市)
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