A study for developing a risk assessment battery for occupational trichloroethylene hypersensitivity syndrome

• Project/Area Number: 24406019
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 海外学術
• Research Field: Hygiene
• Research Institution: Nagoya City University
• Principal Investigator: Kamijima Michihiro 名古屋市立大学, 医学(系)研究科(研究院), 教授 (80281070)
• Co-Investigator(Kenkyū-buntansha): NASU Tamie 中部大学, 生命健康科学部, 教授 (10020794) ; NAITO Hisao 藤田保健衛生大学, 医学部, 講師 (90547556) ; YAMANOSHITA Osamu 中部大学, 生命健康科学部, 講師 (50424924)
• Co-Investigator(Renkei-kenkyūsha): ITO Yuki 名古屋市立大学, 大学院医学研究科, 講師 (80452192)
• Research Collaborator: Wang Hailan 中国広東省職業病防治院, 主任医師 ; Huang Hanlin 中国広東省職業病防治院, 院長
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000); Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
• Keywords: トリクロロエチレン / 重症薬疹 / 過敏性症候群 / ヒトヘルペスウイルス6型 / 有機溶剤 / 過敏症症候群 / ﾄﾘｸﾛﾛｴﾁﾚﾝ / ﾋﾄﾍﾙﾍﾟｽｳｨﾙｽ６型 / ﾋﾄﾍﾟﾙﾍﾟｽｳｨﾙｽ6型 / 皮膚障害 / 遺伝子多型 / 尿中代謝物 / 生物学的モニタリング

Outline of Final Research Achievements

Trichloroethylene is a solvent used worldwide to degrease industrial products such as metal parts and circuit boards. Generalized hypersensitivity dermatitis accompanying hepatitis, which is internationally called as occupational trichloroethylene hypersensitivity syndrome, has occurred in China since late 1990’s. This project aimed at clarifying risk factors for occurring and developing this disease. Exposure dose, individual susceptible factors, and biomarkers for reactivation of latent human herpesvirus 6 were investigated. Finally, an occupational exposure standard to prevent this disease was proposed.

Research Products

• [Int'l Joint Research] 広東省職業病防治院(中国)
• [Journal Article] Recommendation of Occupational Exposure Limits (2015-2016) (2015)
  • Author(s): Ｅｎｄｏ Ｇ， Ｉｃｈｉｈａｒａ Ｇ ｅｔ ａｌ．The Japan Society for Occupational Health
  • Journal Title: Journal of Occupational Health Volume: 57 Issue: 4 Pages: 394-417
  • DOI: 10.1539/joh.ROEL2015
  • NAID: 130005106139
  • ISSN: 1341-9145, 1348-9585
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sex Differences in Metabolism of Trichloroethylene and Trichloroethanol in Guinea Pigs (2013)
  • Author(s): Hibino Y, Wang H, Naito H, Zhao N, Wang D, Jia X, Li H, Song X, Liu L, Huang Y, Ito Y, Huang H, Kamijima M, Nakajima T
  • Journal Title: Journal of Occupational Health Volume: 55 Issue: 6 Pages: 443-449
  • DOI: 10.1539/joh.13-0091-OA
  • NAID: 10031203865
  • ISSN: 1341-9145, 1348-9585
  • Peer Reviewed / Open Access
• [Journal Article] Occupational trichloroethylene hypersensitivity syndrome: Human herpesvirus 6 reactivation and rash phenotypes (2013)
  • Author(s): Kamijima M, Wang H, Yamanoshita O, Ito Y, Xia L, Yanagiba Y, Chen C, Okamura A, Huang Z, Qiu X, Song X, Cai T, Liu L, Ge Y, Deng Y, Naito H, Yoshikawa T, Tohyama M, Li L, Huang H, Nakajima T
  • Journal Title: J. Occup Health Volume: 72 Issue: 3 Pages: 443-449
  • DOI: 10.1016/j.jdermsci.2013.07.003
  • Peer Reviewed
• [Journal Article] 有機溶剤トリクロロエチレンによる職業性過敏症症候群 (2012)
  • Author(s): 上島通浩、王海蘭、那須民江
  • Journal Title: アレルギー・免疫 Volume: 19 Pages: 299-309
• [Presentation] トリクロロエチレンによるHypersensitivity-患者の曝露濃度から許容濃度再考の必要性を考察する- (2016)
  • Author(s): 那須民江、王棟、王海蘭、山ノ下理、伊藤由起、内藤久雄、上島通浩
  • Organizer: 第89回日本産業衛生学会
  • Place of Presentation: 福島県文化センター（福島市）
  • Year and Date: 2016-05-24
• [Presentation] トリクロロエチレン曝露量とHLA遺伝型に対する皮膚過敏症への影響 (2015)
  • Author(s): 山ノ下理、上島通浩、王海蘭、伊藤由紀、内藤久雄、那須民江
  • Organizer: 平成27年度 日本産業衛生学会東海地方会学会
  • Place of Presentation: 名古屋大学（名古屋市）
  • Year and Date: 2015-11-14
• [Presentation] トリクロロエチレンによるHypersensitivity－15年間の日中共同研究による患者の曝露濃度推移の考察－ (2015)
  • Author(s): 那須民江、王棟、王海蘭、山ノ下理、伊藤由紀、内藤久雄、上島通浩
  • Organizer: 平成27年度 日本産業衛生学会東海地方会学会
  • Place of Presentation: 名古屋大学（名古屋市）
  • Year and Date: 2015-11-14
• [Presentation] トリクロロエチレンによる重症皮膚肝障害の個体感受性マーカーと尿中代謝物との関連性の解析. (2014)
  • Author(s): 山ノ下理、王海蘭、内藤久雄、伊藤由起、王棟、上島通浩、黄漢林、那須民江.
  • Organizer: 第87回日本産業衛生学会
  • Place of Presentation: 岡山ｺﾝﾍﾞﾝｼｮﾝｾﾝﾀｰ（岡山県・岡山市）
  • Year and Date: 2014-05-21 – 2014-05-24
• [Presentation] トリクロロエチレンによる重症皮膚肝障害の個体感受性マーカーと尿中代謝物との関連性の解析 (2014)
  • Author(s): 山ノ下理、王海蘭、内藤久雄、伊藤由起、王棟、上島通浩、黄漢林、那須民江.
  • Organizer: 第87回日本産業衛生学会
  • Place of Presentation: 岡山コンベンションセンター（岡山）
• [Presentation] Not only trichloroethylene but also trichloroethanol may have sensitizing potential in Guinea Pig. (2013)
  • Author(s): Naito H, Hibino Y, Zhao N, Li H, Song X, Liu L, Huang Y, Wang H, Ito Y, Kamijima M, Nakajima T
  • Organizer: XIII International Congress of Toxicology
  • Place of Presentation: COEX convention center (Seoul, Korea）
• [Presentation] Human herpesvirus 6 reactivation in trichloroethylene-induced hypersensitivity dermatitis (2013)
  • Author(s): Kamijima M, Yamanoshita O,Ito Y,Nakajima T
  • Organizer: 8th International Conference on HHV-6&7
  • Place of Presentation: UIC Espaces Congrès（Paris France)
• [Presentation] Human herpesvirus 6 reactivation in trichloroethylene-induced hypersen sitivity dermatitis. (2013)
  • Author(s): Kamijima M Yamanoshita O, Ito Y, Nakajima T, et al.
  • Organizer: 8th International Conference on HHV-6&7
  • Place of Presentation: Paris
• [Book] Chapter 3 Hypersensitivity Dermatitis and Hepatitis.In: Trichloroethylene：Toxicity and Health Risks. (2014)
  • Author(s): Michihiro Kamijima,Hailan Wang, Osamu Yamanoshita, Yuki Ito, Tamie Nakajima.
  • Publisher: Humama Press
• [Book] Trichloroethylene：Toxicity and Health Risks Molecular and Integrative Toxicology. (2014)
  • Author(s): Kamijima M,Yamanoshita O,Nakajima T et al.
  • Total Pages: 245
  • Publisher: Humama Press
• [Remarks] 名古屋市立大学大学院医学研究科環境労働衛生学分野ホームページ「研究内容」
  • URL: http://www.med.nagoya-cu.ac.jp/hygiene.dir/study.html