• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Suport of Infection Control of MDRAb in Thailand

Research Project

Project/Area Number 24406022
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section海外学術
Research Field Public health/Health science
Research InstitutionOsaka University

Principal Investigator

TOMONO Kazunori  大阪大学, 医学(系)研究科(研究院), 教授 (40202204)

Co-Investigator(Kenkyū-buntansha) OISHI Kazunori  国立感染症研究所, 感染症疫学センター, センター長 (80160414)
SEKI Masafumi  大阪大学, 医学部付属病院, 講師 (80432970)
AKEDA Yukihiro  大阪大学, 微生物病研究所, 特任講師(常勤) (60444527)
Research Collaborator HAMAGUCHI Shigeto  
YAMAMOTO Norihisa  
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywords院内感染 / 多剤耐性アシネトバクター・バウマニ / ICU / 薬剤耐性菌 / アシネトバクター / タイ国 / アウトブレイク
Outline of Final Research Achievements

Multi-drugs-resistant A. baumannii (MDRAb) is associated with high morbidity and mortality as well as longer hospital stays in a hospital. We established a MDRAb-LAMP method for detecting blaOXA-23-positive MDRAb, which accounts for approximately 95% of MDRAb in Thailand. In this study, we evaluated the efficacy of rapid detection and intervention for nosocomial infection among ICU patients in Thai hospital. All the patients screened for MDRAb with both culture and LAMP by rectal swab and/or sputum (intubated patients only) on admission, weekly and on discharge. By using LAMP method as surveillance, we were able to reduce the rate of MDRAb transmission from 26.8 to 13.8 cases per 1000 patient days (p=0.03).MDRAb-LAMP enabled us to find positive patients and start appropriate interventions earlier and we were able to clarify the effect of rapid detection to reduce nosocomial infection.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • Research Products

    (51 results)

All 2015 2014 2013 2012 Other

All Journal Article (30 results) (of which Peer Reviewed: 25 results,  Open Access: 4 results) Presentation (19 results) Book (2 results)

  • [Journal Article] Mycobacterium avium complex-associated peritonitis with CAPD after unrelated bone marrow transplantation.2014

    • Author(s)
      Miyashita E, Yoshida H, Mori D, Nakagawa N, Miyamura T, Ohta H, Seki M, Tomono K, Hashii Y, Ozono K
    • Journal Title

      Pediatr Int

      Volume: 56(6) Issue: 6

    • DOI

      10.1111/ped.12463

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Presence of neutrophil extracellular traps and citrullinated histone h3 in the bloodstream of critically ill patients2014

    • Author(s)
      Hirose T, Hamaguchi S, Matsumoto N, et a
    • Journal Title

      PLoS One

      Volume: Nov 13;9(11) Issue: 11 Pages: e111755-e111755

    • DOI

      10.1371/journal.pone.0111755

    • NAID

      120006986309

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protective properties of a fusion pneumococcal surface protein A (PspA) vaccine against pneumococcal challenge by five different PspA clades in mice.Vaccine.2014

    • Author(s)
      Piao Z, Akeda Y, Takeuchi D, Ishii KJ, Ubukata K, Briles DE, Tomono K, Oishi K
    • Journal Title

      Vaccine

      Volume: 32(43) Pages: 5607-13

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antibiotic susceptibility survey of blood-borne MRSA isolates in Japan from 2008 through 2011.2014

    • Author(s)
      Hanaki H, Cui L, Ikeda-Dantsuji Y, Nakae T, Honda J, Yanagihara K, Takesue Y, Matsumoto T, Sunakawa K, Kaku M, Tomono K, Fukuchi K, Kusachi S, Mikamo H, Takata T, Otsuka Y, Nagura O, Fujitani S, Aoki Y, Yamaguchi Y, Tateda K, Kadota J, Kohno S, Niki Y.
    • Journal Title

      J Infect Chemother.

      Volume: 20(9) Issue: 9 Pages: 527-34

    • DOI

      10.1016/j.jiac.2014.06.012

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distribution of Candida species isolated from blood cultures in hospitals in Osaka, Japan.2014

    • Author(s)
      Morii D, Seki M, Binongo JN, Ban R, Kobayashi A, Sata M, Hashimoto S, Shimizu J, Morita S, Tomono K
    • Journal Title

      J Infect Chemother.

      Volume: 20(9) Issue: 9 Pages: 558-62

    • DOI

      10.1016/j.jiac.2014.05.009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel Anti-Microbial Peptide SR-0379 Accelerates Wound Healing via the PI3 Kinase/Akt/mTOR Pathway.2014

    • Author(s)
      Tomioka H., et.al.
    • Journal Title

      PLoS One

      Volume: Mar27;9(3) Issue: 3 Pages: e92597-e92597

    • DOI

      10.1371/journal.pone.0092597

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neutrophil extracellular traps in bronchial aspirates: a quantitative analysis2014

    • Author(s)
      Hamaguchi S., et.al.
    • Journal Title

      European Respiratory Journal

      Volume: 印刷中 Issue: 6 Pages: 1709-18

    • DOI

      10.1183/09031936.00139813

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Correlation between outbreaks of multidrug-resistant Pseudomonas aeruginosa infection and use of bronchoscopes suggested by epidemiological analysis.2014

    • Author(s)
      Machida H, Seki M, Yoshioka N, Yabuno K, Miyawaki K, Yoshida H, Yamamoto N, Hamaguchi S,Tomono K
    • Journal Title

      Biol Pharm Bull

      Volume: 37(1) Pages: 26-30

    • NAID

      130003382093

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肺炎の迅速原因菌検査 グラム染色2014

    • Author(s)
      朝野 和典
    • Journal Title

      呼吸研究

      Volume: 33:9 Pages: 942-944

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 呼吸器感染症の治療と予防 ストップ肺炎キャンペーン2014

    • Author(s)
      朝野 和典
    • Journal Title

      日本胸部臨床

      Volume: 73

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 結核2014

    • Author(s)
      朝野 和典
    • Journal Title

      感染症道場メディカルレビュー社

      Volume: Vol3.No.3 Pages: 55-56

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 院内感染2014

    • Author(s)
      朝野 和典
    • Journal Title

      臨床雑誌 内科

      Volume: Vol.113No.6 Pages: 997-999

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 医療・介護関連肺炎(NHCAP)の概念と診療2014

    • Author(s)
      朝野 和典 関 雅文
    • Journal Title

      日本内科学会誌

      Volume: 102 Pages: 2882-2887

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Correlation between outbreaks of multidrug-resistant Pseudomonas aeruginosa infection and use of bronchoscopes suggested by epidemiological analysis.2014

    • Author(s)
      Machida H., et.al.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 37 Pages: 26-30

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of neutrophil extracellular traps in blood of patients with systemic inflammatory response syndrome.2013

    • Author(s)
      Hamaguchi S., Hirose T., Akeda Y., Matsumoto N. et al.
    • Journal Title

      J. Int. Med. Res.

      Volume: 41 Issue: 1 Pages: 162-168

    • DOI

      10.1177/0300060513475958

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pneumorachis associated with multiorgan infection due to Citrobacter koseri.2013

    • Author(s)
      Yamamoto N., Takegawa R., Seki M., Takahashi K., Tahara K., Hirose T., Hamaguchi S., Irisawa T., Matsumoto N. et al.
    • Journal Title

      Diagn. Microbiol. Infect. Dis.

      Volume: 77 Issue: 4 Pages: 370-372

    • DOI

      10.1016/j.diagmicrobio.2013.08.017

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical practice guidelines for nursing- and healthcare-associated pneumonia (NHCAP)2013

    • Author(s)
      Kohno S., et.al
    • Journal Title

      Respiratory Investigation

      Volume: 51 Issue: 2 Pages: 103-126

    • DOI

      10.1016/j.resinv.2012.11.001

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-dose, short-interval daptomycin regimen was safe and well tolerated in three patients with chronic renal failure2013

    • Author(s)
      Yabuno S., et.al
    • Journal Title

      Clinical Pharmacology

      Volume: 5 Pages: 161-166

    • DOI

      10.2147/cpaa.s53681

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fatal sepsis caused by an unusual Klebsiella species that was misidentified by an automated identification system.2013

    • Author(s)
      Seki M., et. al.
    • Journal Title

      Journal of Medical Microbiology

      Volume: (印刷中) Issue: 5 Pages: 801-803

    • DOI

      10.1099/jmm.0.051334-0

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pneumococcal polysaccharide vaccination in rheumatoid arthritis patients receiving tocilizumab therapy.2013

    • Author(s)
      Mori S., et.al.
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: (印刷中) Issue: 8 Pages: 1362-1366

    • DOI

      10.1136/annrheumdis-2012-202658

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low opsonic activity to the infecting serotype in pediatric patients with invasive pneumococcal disease2013

    • Author(s)
      Oishi T, Ishiwada N, Matsubara K, Nishi J, Chang B, Tamura K, Akeda Y, Ihara T, Nahm MH, Oishi K; the Japanese IPD Study Group
    • Journal Title

      Vaccine

      Volume: 31(5) Issue: 5 Pages: 845-849

    • DOI

      10.1016/j.vaccine.2012.11.010

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nosocomial outbreak of mul〓idrug-resistant Pseudomonas aeruginosa caused by damaged transesophageal echocardiogram probe used in cardiovascular surgical operations2013

    • Author(s)
      Seki M., et. al.
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: (印刷中) Issue: 4 Pages: 677-681

    • DOI

      10.1007/s10156-012-0542-0

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fifteen Streptococcus suis serotypes identified by multiplex PCR.2012

    • Author(s)
      Kerdsin A
    • Journal Title

      Journal of Medical Microbiology

      Volume: 61 Issue: 12 Pages: 1669-1672

    • DOI

      10.1099/jmm.0.048587-0

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional cloning of Vibrio parahaemolyticus type III secretion system 1 in Escherichia coli K-12 strain as a molecular syringe.2012

    • Author(s)
      Akeda Y, Kimura T, Yamasaki A, Kodama T, Iida T, Honda T, Oishi K.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 427(2) Issue: 2 Pages: 242-7

    • DOI

      10.1016/j.bbrc.2012.09.018

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Case of invasive nontypable Haemophilus influenzac respiratory tract infection with a large quanity of neutrophil extracellular traps in sputum2012

    • Author(s)
      Hamaguchi S., et. al.
    • Journal Title

      Journal of Inflammation Research

      Volume: 5 Pages: 137-140

    • DOI

      10.2147/jir.s39497

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between the Consumption of Meropenem or Doripenem and Meropenem Susceptibility of <i>Pseudomonas aeruginosa</i> in a University Hospital in Japan2012

    • Author(s)
      Miyawaki K., et. al.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 35 Issue: 6 Pages: 946-949

    • DOI

      10.1248/bpb.35.946

    • NAID

      130001872178

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methicillin-resistant Staphylococcus aureus bacteremia at a university hospital in Japan2012

    • Author(s)
      Isobe M., et. al.
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: 18 Issue: 6 Pages: 841-847

    • DOI

      10.1007/s10156-012-0423-6

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loading regimen required to rapidly achieve therapeutic trough plasma concentration of teicoplanin and evaluation of clinical features2012

    • Author(s)
      Seki M., et. al.
    • Journal Title

      Clinical Pharmacology

      Volume: 4 Pages: 71-75

    • DOI

      10.2147/cpaa.s37528

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic changes in the expression of neutrophil extracellular traps in acute respiratory infections2012

    • Author(s)
      Hirose T., et. al.
    • Journal Title

      American Journal of Repiratory and Critical Care Medicine

      Volume: 15 Issue: 10 Pages: 1130-1131

    • DOI

      10.1164/ajrccm.185.10.1130

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Limited detectability of linezolid-resistant Staphylococcus aureus by the Etest method and its improvement using enriched media2012

    • Author(s)
      Ikeda-Dantsuji Y., et. al.
    • Journal Title

      Journal of Medical Microbiology

      Volume: 61 Issue: 7 Pages: 998-1002

    • DOI

      10.1099/jmm.0.043695-0

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] The role of neutrophil extracellular traps against soft tissue infections2015

    • Author(s)
      Yamamoto N, Ojima M, Hamaguchi S,Hirose T, Takagawa R, Matsumoto N, Irisawa T, seki M, Tasaki O, ShimazuT, Tomono K
    • Organizer
      35Th INTERNATIONAL SYMPOSIUM ON intensive care and EMERGENCY MEDICINE
    • Place of Presentation
      Square Brussels Meeting Centreブリュッセル(ベルギー)
    • Year and Date
      2015-03-16 – 2015-03-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Nosocomial Transmission of Carbapenem-Resistant Acinetobacter baumannii (CRAb) among ICU2014

    • Author(s)
      Yamamoto N,Hamaguchi S, Akeda Y, Anusak Kerdsin,Santanirand Pitak, Seki M, Kumthorn Malathum, Oishi K, Tomono K
    • Organizer
      IDWeeK2014
    • Place of Presentation
      The Pennsylvania Convention Centerフィラデルフィア(アメリカ)
    • Year and Date
      2014-10-07 – 2014-10-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Direct LAMP assy from clinical sample for Carbapenem resistant A. baumannii2014

    • Author(s)
      Hamaguchi S,Yamamoto N, Akeda Y, Anusak Kerdsin,Santanirand Pitak, Seki M, Kumthorn Malathum, Oishi K, Tomono K
    • Organizer
      ERS Annual Congress Munich 2014
    • Place of Presentation
      Internationales Congress Centerミューヘン (ドイツ)
    • Year and Date
      2014-09-06 – 2014-09-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肺炎球菌に対する乳幼児期の血清疫学調査2014

    • Author(s)
      濱口重人,明田幸宏,朝野和典,大石和徳
    • Organizer
      第88回日本感染症学会
    • Place of Presentation
      ヒルトン福岡シーホーク(福岡県福岡市)
    • Year and Date
      2014-06-18 – 2014-06-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] LAMP法を用いた多剤耐性アシネトバクター・バウマニ検出法の確立2014

    • Author(s)
      山本倫久,濱口重人,明田幸宏,関雅文,大石和徳、朝野和典
    • Organizer
      第88回日本感染症学会
    • Place of Presentation
      ヒルトン福岡シーホーク(福岡県福岡市)
    • Year and Date
      2014-06-18 – 2014-06-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] 当院における血液培養検体からのカンジダ属菌の検出状況2014

    • Author(s)
      宮脇康至,薮野佳小里,関雅文,三輪芳弘,朝野和典
    • Organizer
      第62回日本化学療法学会
    • Place of Presentation
      ヒルトン福岡シーホーク(福岡県福岡市)
    • Year and Date
      2014-06-18 – 2014-06-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] メロぺネム1日6g投与の有効性・安全性の評価2014

    • Author(s)
      宮脇康至,薮野佳小里,関雅文,三輪芳弘,朝野和典
    • Organizer
      第62回日本化学療法学会
    • Place of Presentation
      ヒルトン福岡シーホーク(福岡県福岡市)
    • Year and Date
      2014-06-18 – 2014-06-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] LAMP法を用いた多剤耐性アシネトバクター・バウマニ検出法の確立2014

    • Author(s)
      山本 倫久、他
    • Organizer
      第87回日本細菌学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Quantitative Analysis of Neutrophil Extracellular Traps in Acute Respiratory Infection2013

    • Author(s)
      濱口重人、他
    • Organizer
      第53回日本呼吸器学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Neutrophil extracellular traps were found in the sputum of the patients of nontypeable Haemophilus influenza pneumonia.2013

    • Author(s)
      山本倫久、他
    • Organizer
      第53回日本呼吸器学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Neutrophil Extracellular Traps In Acute Respiratory Infection: A Quantitative Analysis In Sputum2013

    • Author(s)
      濱口重人、他
    • Organizer
      American Thoracic Society 2013
    • Place of Presentation
      Philadelphia(アメリカ)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The Pathophysiological Comparison of Secondary Pneumococcal Pneumonia After H1N1 Pandemic 2009 or H1N1 New Caledonia Influenza Virus Infection.2013

    • Author(s)
      山本倫久、他
    • Organizer
      American Thoracic Society 2013
    • Place of Presentation
      Philadelphia(アメリカ)
    • Related Report
      2013 Annual Research Report
  • [Presentation] LAMP 法を用いた多剤耐性アシネトバクター・バウマニ検出法の確立2013

    • Author(s)
      濱口 重人、他
    • Organizer
      第82回日本感染症学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Rapid and Simple Detection of Carbapenem Resistant Acinetobacter baumannii by Loop-Mediated Isothermal Amplification Method2013

    • Author(s)
      山本 倫久、他
    • Organizer
      53rd Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Place of Presentation
      Denver(アメリカ)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Hibワクチン免疫マウスにおける抗PRP IgG ELISA, 血清殺菌能測定法の確立2012

    • Author(s)
      明田幸宏, 他
    • Organizer
      第16回日本ワクチン学会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] インフルエンザウイルスの相違による二次性細菌性肺炎の病態比較2012

    • Author(s)
      明田幸宏, 他
    • Organizer
      第55回日本感染症学会中日本地方会
    • Place of Presentation
      アクロス福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] マイクロアレイを用いたインフルエンザウイルス感染に伴う二次性細菌性肺炎発症に関与する宿主および細菌性因子の網羅的解析2012

    • Author(s)
      明田幸宏, 他
    • Organizer
      第86回日本感染症学会総会
    • Place of Presentation
      長崎ブリックホール
    • Related Report
      2012 Annual Research Report
  • [Presentation] Hibワクチン免疫マウスにおける抗PRP IgG ELISA, 血清殺菌能測定法の確立2012

    • Author(s)
      明田幸宏, 他
    • Organizer
      第16回日本ワクチン学会
    • Place of Presentation
      第16回日本ワクチン学会
    • Related Report
      2012 Annual Research Report
  • [Presentation] LAMP法を用いた多剤耐性アシネトバクター・バウマニ検出法の確立

    • Author(s)
      濱口 重人、他
    • Organizer
      第66回細菌学会関西支部会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Book] 呼吸器疾患診療最新ガイドライン2014

    • Author(s)
      朝野和典
    • Publisher
      総合医学社
    • Related Report
      2014 Annual Research Report
  • [Book] 糖尿病研修ノート2014

    • Author(s)
      朝野 和典
    • Publisher
      診断と治療社
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2012-04-24   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi