| Project/Area Number |
24406025
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 海外学術 |
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| Research Field |
Legal medicine
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAJIMA Katsuyuki 群馬大学大学院, 保健学研究科, 客員教授 (10444051)
OKAJIMA Fumikazu 群馬大学, 生体調節研究所, 教授 (30142748)
OSAWA Motoki 東海大学, 医学部, 教授 (90213686)
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| Research Collaborator |
NAKANO Takamitsu 群馬大学, 医学部, 非常勤講師
BRUGADA Ramon スペイン・ジローナ大学, 心臓血管系疾患遺伝子研究所, 教授
SIRISUP Nantana タイ・チュラロンコン大学, 医学部, 准教授
CHUTIVONGSE Panuwat タイ・チュラロンコン大学, 医学部, 医師
IASLAM Mohammed N. マレーシア・国立マラ工科大学, 医学部, 教授
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2012: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Keywords | ポックリ病 / Lai-Tai / 突然死 / 東南アジア / 不整脈 / Brugada症候群 / 冠動脈攣縮 / 脂質代謝 |
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| Outline of Final Research Achievements |
Pokkuri Death Syndrome (PDS) is a sudden unexpected nocturnal death of unknown cause in mostly young males that has been reported in Japan and other South-Asian countries. Together with the counterpart of this study in Thailand, we have shown that Lai-Tai, a sudden death syndrome in Thailand, has similar autopsy findings with PDS in Japan. As for the background it was more like that of PDS in postwar period. Most Lai-Tai cases were found in heavy physical labor workers with poor economic and sanitary conditions. Genetic analysis of SC5NA, responsible for Brugada syndrome and other sudden arrhythmic death causing disease was performed. We have found some mutations in our PDS cases and now are preparing for the functional analysis. As for the Lai-Tai cases, they are under genetic analysis.
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