Comparison of outcomes and their related risk factors observed in Asian patients with those in Japanese diabetic nephropathy patients
Project/Area Number |
24406028
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 海外学術 |
Research Field |
Kidney internal medicine
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Research Institution | Kanazawa University |
Principal Investigator |
WADA Takashi 金沢大学, 医学系, 教授 (40334784)
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Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Shoichi 名古屋大学, 医学(系)研究科(研究院), 准教授 (10362253)
今井 圓裕 名古屋大学, 医学(系)研究科(研究院), その他 (00223305)
|
Co-Investigator(Renkei-kenkyūsha) |
YASUDA Yoshinari 名古屋大学, 医学(系)研究科(研究院), 准教授 (60432259)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 糖尿病性腎症 / アジア人種 / コホート / 腎機能 / アルブミン尿 / 腎予後 / 心血管病変 / 生命予後 |
Outline of Final Research Achievements |
This study was aimed to compare outcomes and their related risk factors in patients with diabetic nephropathy among Asian countries based on our Japanese database in patients with diabetic nephropathy. Our study strongly showed that the presence of macroalbuminuria increased the adjusted hazard ratios for kidney event (Wada, et al. Clin Exp Nephrol 2014). Diabetic nephropathy score, based on the prognostic factors, well predicted incidence rates per 1000 patient/year for kidney event, cardiovascular events and death. Then, we have established international collaborative research team on diabetic nephropathy among Asian countries. The results of advanced diabetic patients from Taiwanese diabetic cohorts confirmed that albuminuria was of importance for kidney prognosis. In addition, these showed that related prognostic risk factors from our Japanese database were closely relevant to those of Asian diabetic nephropathy patients.
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Report
(4 results)
Research Products
(70 results)
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[Journal Article] Impact of kidney function and urinary protein excretion on intima-media thickness in Japanese patients with type 2 diabetes2015
Author(s)
Nakade Y, Toyama T, Furuichi K, Kitajima S, Miyajima Y, Fukamachi M, Sagara A, Shinozaki Y, Hara A, Shimizu M, Iwata Y, Oe H, Nagahara M, Horita H, Sakai Y, Kaneko S, Wada T
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Journal Title
Clin Exp Nephrol
Volume: in press
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] A new classification of Diabetic Nephropathy 2014: a report from Joint Committee on Diabetic Nephropathy2015
Author(s)
Haneda M, Utsunomiya K, Koya D, Babazono T, Moriya T, Makino H, Kimura K, Suzuki Y, Wada T, Ogawa S, Inaba M, Kanno Y, Shigematsu T, Masakane I, Tsuchiya K, Honda K, Ichikawa K, Shide K
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Journal Title
Clin Exp Nephrol
Volume: 19
Issue: 1
Pages: 1-5
DOI
Related Report
Open Access
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[Journal Article] Pro-inflammatory/Th1 gene expression shift in high glucose stimulated mesangial cells and tubular epithelial cells.2014
Author(s)
Iwata Y, Furuichi K, Hashimoto S, Yokota K, Yasuda H, Sakai N, Kitajima S, Toyama T, Shinozaki Y, Sagara A, Matsushima K, Kaneko S, Wada T.
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Journal Title
Biochem Biophys Res Commun
Volume: 443
Issue: 3
Pages: 969-974
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical impacts of albuminuria and glomerular filtration rate on renal, cardiovascular events, and all-cause mortality in Japanese patients with type 2 diabetes.2014
Author(s)
Wada T, Haneda M, Furuichi K, Babazono T, Yokoyama H, Iseki K, Araki SI, Ninomiya T, Hara S, Suzuki Y, Iwano M, Kusano E, Moriya T, Satoh H, Nakamura H, Shimizu M, Toyama T, Hara A, Makino H; The Research Group of Diabetic Nephropathy, Ministry of Health, Labour, and Welfare of Japan
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Journal Title
Clin Exp Nephrol
Volume: -
Issue: 4
Pages: 613-620
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Impact of kidney function and urinary protein excretion on pulmonary function in Japanese patients with chronic kidney disease.2014
Author(s)
Nakade Y, Toyama T, Furuichi K, Kitajima S, Ohkura N, Sagara A, Shinozaki Y, Hara A, Kitagawa K, Shimizu M, Iwata Y, Oe H, Nagahara M, Horita H, Sakai Y, Kaneko S, Wada T.
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Journal Title
Clin Exp Nephrol
Volume: -
Issue: 5
Pages: 763-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Coordinated Changes in DNA Methylation in Antigen-Specific Memory CD4 T Cells2013
Author(s)
Hashimoto S, Ogoshi K, Sasaki A, Abe J, Qu W, Nakatani Y, Ahsan B, Oshima K, Shand FH, Ametani A, Suzuki Y, Kaneko S, Wada T, Hattori M, Sugano S,Morishita S, Matsushima K
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Journal Title
J Immunol
Volume: 190
Issue: 8
Pages: 4076-4091
DOI
Related Report
Peer Reviewed
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[Journal Article] Adipose tissue-derived stem cells as a regenerative therapy for a mouse steatohepatitis-induced cirrhosis model2013
Author(s)
A Seki, S Y akai, T Komura, A Nasti, K Yoshida, M Higashimoto, M Honda, S Usui, M Takamura, T Takamura, T Ochiya, K Furuichi, T Wada, S Kaneko
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Journal Title
Hepatology
Volume: 58(3)
Issue: 3
Pages: 1133-42
DOI
Related Report
Peer Reviewed
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[Journal Article] Long-term outcomes of Japanese type 2 diabetic patients with biopsy-proven diabetic nephropathy.2013
Author(s)
Shimizu M, Furuichi K, Toyama T, Kitajima S, Hara A, Kitagawa K, Iwata Y, Sakai N, Takamura T, Yoshimura M, Yokoyama H, Kaneko S, Wada T and Kanazawa Study Group for Renal Diseases and Hypertension.
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Journal Title
Diabetes Care
Volume: 36
Issue: 11
Pages: 3655-3662
DOI
Related Report
Peer Reviewed
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[Journal Article] CCL2/CCR2 augments the production of transforming growth factor-beta1, type 1 collagen and CCL2 by human CD45-/collagen 1-positive cells under high glucose concentrations.2013
Author(s)
Hara A, Sakai N, Furuichi K, Sakai Y, Takeya M, Bucala R, Mukaida N, Takuwa Y, Matsushima K, Kaneko S, Wada T.
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Journal Title
Clin Exp Nephrol.
Volume: 17
Issue: 6
Pages: 793-804
DOI
Related Report
Peer Reviewed
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[Journal Article] Research Group of Diabetic Nephropathy, Ministry of Health, Labour, and Welfare of Japan. Japan Diabetic Nephropathy Cohort Study : study design, methods, and implementation2013
Author(s)
Furuichi K1, Shimizu M, Toyama T, Koya D, Koshino Y, Abe H, Mori K, Satoh H, Imanishi M, Iwano M, Yamauchi H, Kusano E, Fujimoto S, Suzuki Y, Okuda S, Kitagawa K, Iwata Y, Kaneko S, Nishi S, Yokoyama H, Ueda Y, Haneda M, Makino H, Wada T
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Journal Title
Clin Exp Nephrol
Volume: 17
Issue: 6
Pages: 819-826
DOI
Related Report
Peer Reviewed
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[Journal Article] Validation of a newly proposed histopathological classification in Japanese patients with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis.2013
Author(s)
Iwakiri T, Fujimoto S, Kitagawa K, Furuichi K, Yamahana J, Matsuura Y, Yamashita A, Uezono S, Shimao Y, Hisanaga S, Tokura T, Wada T, Kitamura K, Asada Y.
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Journal Title
BMC Nephrol
Volume: 14
Issue: 1
Pages: 125-125
DOI
Related Report
Peer Reviewed
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[Journal Article] Adipose tissue derived stromal stem cell therapy in murine ConA-derived hepatitis is dependent on myeloid-lineage and CD4+ T-cell suppression.2013
Author(s)
Higashimoto M, Sakai Y, Takamura M, Usui S, Nasti A, Yoshida K, Seki A, Komura T, Honda M, Wada T, Furuichi K, Ochiya T, Kaneko S.
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Journal Title
Eur J Immunol
Volume: 43
Issue: 11
Pages: 2956-68
DOI
Related Report
Peer Reviewed
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[Journal Article] Glycoprotein hyposialylation gives rise to a nephrotic-like syndrome that is prevented by sialic acid administration in GNE V572L point-mutant mice2012
Author(s)
Ito, M., Sugihara, K., Asaka, T., Toyama, T., Yo sh ih ar a, T., Furuichi, K., Wada, T. and Asano, M.
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Journal Title
PLoS ONE
Volume: 7
Issue: 1
Pages: 1-13
DOI
Related Report
Peer Reviewed
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[Presentation] 糖尿病性腎症の管理2012
Author(s)
古市賢吾, 和田隆志
Organizer
第42回日本腎臓学会西部学術大会
Place of Presentation
沖縄コンベンションセンター(沖縄)(招待講演)
Year and Date
2012-10-26
Related Report
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[Presentation] 糖尿病性腎症2012
Author(s)
和田隆志
Organizer
第42回日本腎臓学会東部学術大会
Place of Presentation
朱鷺メッセ(新潟)(招待講演)
Year and Date
2012-10-14
Related Report
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