| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
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| Outline of Final Research Achievements |
During this study we collected from affected after Chernobyl fallout territories of Belarus and Ukraine paraffin-embedded tissues, frozen samples (if available) and blood samples from the most aggressive (young age of exposure and short-latent period) pediatric PTCs (operated from 1990 and until October 1998), which are not included in the Chernobyl Tissue Bank and established the Paraffin Tissue Bank. For all collected PTC samples we made data base of patients includes demographic, clinical and morphological information.
Using RNA-NGS technique we discovered a new RET rearrangement (TBL1XR1/RET) in pediatric PTC from Belarus. In vitro irradiation of human thyroid cells was able to induce TBL1XR1/RET rearrangement. The occurrence of TBL1XR1/RET rearrangement in PTC of sporadic and radiation-related etiology suggests that it may likely be induced by different genotoxic insults, one of which could be ionizing radiation.
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