Relationship between periodontal infection and HIV infection in Kenya using simultaneous microsphere-based multiplex assays

• Project/Area Number: 24406034
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 海外学術
• Research Field: Periodontal dentistry
• Research Institution: Nagasaki University
• Principal Investigator: NAKAYAMA Koji 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (80150473)
• Co-Investigator(Kenkyū-buntansha): KANEKO Satoshi 長崎大学, 熱帯医学研究所, 教授 (00342907) ; HARA Yoshitaka 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (60159100) ; FUJII Yoshito 長崎大学, 熱帯医学研究所, 助教 (10404237)
• Co-Investigator(Renkei-kenkyūsha): TSUKUBA Tomoko (KADOWAKI Tomoko) 長崎大学, 医歯薬学総合研究科(歯学系), 准教授 (70336080)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
• Keywords: 歯周病原細菌感染 / HIVに対する抗体価 / エイズ / 歯周病 / HIV / ＨＩＶ / HIV感染 / 歯周病原細菌 / ケニア

Outline of Final Research Achievements

We investigated the relationship between levels of plasma antibodies against 4 bacterial species of periodontal pathogens and a level of plasma antibody against HIV in 242 blood samples randomly collected from the general population older than 20 years in Mbita region of Kenya. As a result, we found that groups with higher levels of anti-HIV showed lower levels of anti-periodontal pathogens. This tendency was observed in the relationship between anti-HIV and anti-other pathogens. These results indicate that general suppression of antibody production by HIV infection affects production of anti-periodontal pathogens antibodies.

Research Products

• [Journal Article] Serological surveillance development for tropical infectious diseases using simultaneous microsphere-based multiplex assays and finite mixture models. (2014)
  • Author(s): Fujii Y, Kaneko S, Nzou SM, Mwau M, Njenga SM, Tanigawa C, Kimotho J, Mwangi AW, Kiche I, Matsumoto S, Niki M, Osada-Oka M, Ichinose Y, Inoue M, Itoh M, Tachibana H, Ishii K, Tsuboi T, Yoshida LM, Mondal D, Haque R, Hamano S, Changoma M, Hoshi T, Kamo K, Karama M, Miura M, Hirayama K.
  • Journal Title: PLoS Negl Trop Dis Volume: 8 Issue: 7 Pages: 1-15
  • DOI: 10.1371/journal.pntd.0003040
  • NAID: 120006986460
  • Peer Reviewed / Open Access
• [Journal Article] Analysis of a Lys-specific serine endopeptidase secreted via the type IX secretion system in Porphyromonas gingivalis. (2014)
  • Author(s): Nonaka M, Shoji M, Kadowaki T, Sato K, Yukitake H, Naito M, Nakayama K
  • Journal Title: FEMS Microbiology Letters Volume: in press Issue: 1 Pages: 60-68
  • DOI: 10.1111/1574-6968.12426
  • Peer Reviewed / Open Access
• [Presentation] ケニアにおけるHIV感染と歯周病原細菌感染との関係 (2014)
  • Author(s): 中山浩次
  • Organizer: 第５６回歯科基礎医学会総会
  • Place of Presentation: 福岡国際会議場（福岡市）
  • Year and Date: 2014-09-25 – 2014-09-27