• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Scientific and Practical Approaches to Computationally Hard Problems

Research Project

Project/Area Number 24500023
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Fundamental theory of informatics
Research InstitutionTokyo Denki University

Principal Investigator

Chen Zhi-Zhong  東京電機大学, 理工学部, 教授 (00242933)

Project Period (FY) 2012-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Keywords近似アルゴリズム / 固定パラメータアルゴリズム / バイオインフォマティクス / 組み合わせ最適化 / ハプロタイプアセンブリー / 網状ネットワーク / 生物系統樹のrSPR距離 / 中心列問題 / 生物系統樹のrSPR距離問題 / 最多内部頂点スパニング木問題 / scaffolding / グラフアルゴリズム / 完全マッチング / ハミルトンパス / 乱択アルゴリズム / アルゴリズムの設計と解析 / 最大一致森問題 / 網状ネットワーク問題 / ハプロタイプ組立問題 / Closest文字列問題 / 共有中心列問題 / 固有パラメータアルゴリズム / NP困難性
Outline of Final Research Achievements

We mainly studied several important and fundamental combinatorial optimization problems in bioinformatics such as the rSPR distance problem of two phylogenetic trees, the reticulate network problem of multiple phylogenetic trees, and the closest string problem. All the studied problems are computationally hard and various algorithms had been designed for them before. In this project, we designed new algorithms for the problems and not only rigorously analyzed the theoretical performance of our new algorithms but also implemented them and compared their practical performance against the previous bests. Our results show that the new algorithms are the bests not only in theory but also in practice.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (22 results)

All 2017 2016 2015 2014 2013 2012

All Journal Article (13 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 13 results,  Acknowledgement Compliant: 6 results) Presentation (9 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Algorithms for Pedigree Comparison2017

    • Author(s)
      Zhi-Zhong Chen, Q. Feng, C. Shen, J. Wang, and L. Wang
    • Journal Title

      IEEE/ACM Transactions on Computational Biology and Bioinformatics

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Randomized Fixed-Parameter Algorithms for the Closest String Problem2016

    • Author(s)
      Zhi-Zhong Chen, Bin Ma, and Lusheng Wang
    • Journal Title

      Algorithmica

      Volume: 74 Issue: 1 Pages: 466-484

    • DOI

      10.1007/s00453-014-9952-y

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Better ILP-Based Approaches to Haplotype Assembly2016

    • Author(s)
      Zhi-Zhong Chen, F. Deng, C. Shen, Y. Wang, and L. Wang
    • Journal Title

      Journal of Computational Biology

      Volume: 23 Issue: 7 Pages: 537-552

    • DOI

      10.1089/cmb.2015.0035

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Faster exact computation of rSPR distance2015

    • Author(s)
      Zhi-Zhong Chen
    • Journal Title

      Journal of Combinatorial Optimization

      Volume: 29 Issue: 3 Pages: 605-635

    • DOI

      10.1007/s10878-013-9695-8

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The Parameterized Complexity of the Shared Center Problem2014

    • Author(s)
      Zhi-Zhong Chen
    • Journal Title

      Algorithmica

      Volume: 69 Issue: 2 Pages: 269-293

    • DOI

      10.1007/s00453-012-9730-7

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Parameterized and Approximation Algorithms for Finding Two Disjoint Matchings2014

    • Author(s)
      Zhi-Zhong Chen
    • Journal Title

      Theoretical Computer Science

      Volume: 556 Pages: 85-93

    • DOI

      10.1016/j.tcs.2014.03.030

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Exact algorithms for haplotype assembly from whole-genome sequence data2013

    • Author(s)
      Zhi-Zhong Chen
    • Journal Title

      Bioinformatics

      Volume: 29 Issue: 16 Pages: 1938-1945

    • DOI

      10.1093/bioinformatics/btt349

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] An Ultrafast Tool for Minimum Reticulate Networks2013

    • Author(s)
      Zhi-Zhong Chen
    • Journal Title

      Journal of Computational Biology

      Volume: 20 Issue: 1 Pages: 38-41

    • DOI

      10.1089/cmb.2012.0240

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Fast Tool for Minimum Hybridization Networks2012

    • Author(s)
      Zhi-Zhong Chen
    • Journal Title

      BMC Bioinformatics

      Volume: 13(155) Issue: 1 Pages: 1-11

    • DOI

      10.1186/1471-2105-13-155

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Simultaneous Identification of Duplications, Losses, and Lateral Gene Transfers2012

    • Author(s)
      Zhi-Zhong Chen
    • Journal Title

      IEEE/ACM Transactions on Computational Biology and Bioinformatics

      Volume: 9 Issue: 5 Pages: 1515-1523

    • DOI

      10.1109/tcbb.2012.79

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Algorithms for Reticulate Networks of Multiple Phylogenetic Trees2012

    • Author(s)
      Zhi-Zhong Chen
    • Journal Title

      IEEE/ACM Transactions on Computational Biology and Bioinformatics

      Volume: 9 Issue: 2 Pages: 372-384

    • DOI

      10.1109/tcbb.2011.137

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mutation Region Detection for Closely Related Individuals without a Known Pedigree2012

    • Author(s)
      Zhi-Zhong Chen
    • Journal Title

      IEEE/ACM Transactions on Computational Biology and Bioinformatics

      Volume: 9 Issue: 2 Pages: 499-510

    • DOI

      10.1109/tcbb.2011.134

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Three-String Approach to the Closest String Problem2012

    • Author(s)
      Zhi-Zhong Chen
    • Journal Title

      Journal of Computer and System Sciences

      Volume: 78 Issue: 1 Pages: 164-178

    • DOI

      10.1016/j.jcss.2011.01.003

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] An Approximation Algorithm for Maximum Internal Spanning Tree2017

    • Author(s)
      Zhi-Zhong Chen
    • Organizer
      The 11th International Conference and Workshops on Algorithms and Computation (WALCOM'2017)
    • Place of Presentation
      Hsinchu, Taiwan
    • Year and Date
      2017-03-29
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An Approximation Algorithm for rSPR Distance2016

    • Author(s)
      Zhi-Zhong Chen
    • Organizer
      The 22nd International Computing and Combinatorics Conference (COCOON'2016)
    • Place of Presentation
      Ho Chi Minh city, Vietnam
    • Year and Date
      2016-08-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Better Approximation Algorithms for Scaffolding Problems.2016

    • Author(s)
      Zhi-Zhong Chen
    • Organizer
      The 10th International Frontiers of Algorithmics Workshop (FAW'2016)
    • Place of Presentation
      Qingdao, China
    • Year and Date
      2016-06-30
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Algorithms for Pedigree Comparison2016

    • Author(s)
      Zhi-Zhong Chen
    • Organizer
      The Fourteenth Asia Pacific Bioinformatics Conference (APBC)
    • Place of Presentation
      San Francisco
    • Year and Date
      2016-01-11
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Randomized and Parameterized Algorithms for the Closest String Problem2014

    • Author(s)
      Zhi-Zhong Chen
    • Organizer
      The 25th Annual Symposium on Combinatorial Pattern Matching
    • Place of Presentation
      The Headquarters of Yandex, Moscow, Russia
    • Year and Date
      2014-06-16 – 2014-06-18
    • Related Report
      2014 Research-status Report
  • [Presentation] Identifying duplications and lateral gene transfers simultaneously and rapidly2013

    • Author(s)
      Zhi-Zhong Chen
    • Organizer
      CIBCB 2013
    • Place of Presentation
      Singapore
    • Related Report
      2013 Research-status Report
  • [Presentation] Faster Exact Computation of rSPR Distance2013

    • Author(s)
      Zhi-Zhong Chen
    • Organizer
      FAW-AAIM 2013
    • Place of Presentation
      Dalian, China
    • Related Report
      2013 Research-status Report
  • [Presentation] Parameterized and Approximation Algorithms for Finding Two Disjoint Matchings2013

    • Author(s)
      Zhi-Zhong Chen
    • Organizer
      COCOA 2013
    • Place of Presentation
      Chengdu, China
    • Related Report
      2013 Research-status Report
  • [Presentation] An Improved Approximation Algorithm for the Bandpass-2 Problem2012

    • Author(s)
      Zhi-Zhong Chen
    • Organizer
      The 6th Annual International Conference on Combinatorial Optimization and Applications
    • Place of Presentation
      Helsinki, Finland
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi