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Statistics in medicine when time lags between the start of the exposure and death are very long

Research Project

Project/Area Number 24500349
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Statistical science
Research InstitutionThe Institute of Statistical Mathematics (2014)
Teikyo University (2012-2013)

Principal Investigator

FUNATOGAWA Ikuko  統計数理研究所, 大学共同利用機関等の部局等, 准教授 (80407931)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords喫煙 / 喫煙開始年齢 / 肺癌 / 繰り返し横断調査 / 出生コホート
Outline of Final Research Achievements

There are long time lags between smoking initiation and smoking-attributed mortality, and smoking habits complexly differ across birth cohorts. These make the impacts of smoking on mortality unclear. Long-term changes in smoking initiation and smoking prevalence are shown focusing on birth cohorts, and contrasted to the changes in lung cancer mortality in later ages in Japan and Great Britain. We discussed statistical issues and approaches when time lags between the start of the exposure and death are very long. Lung cancer mortality in Japanese male cohorts was relatively low given the high prevalence of smoking, and early initiation was uncommon in these cohorts. However, early initiation of smoking has become more common in both sexes. The risks in the distant future should not be underestimated.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (23 results)

All 2015 2014 2013 2012 Other

All Journal Article (7 results) (of which Acknowledgement Compliant: 2 results,  Peer Reviewed: 3 results) Presentation (15 results) (of which Invited: 3 results) Book (1 results)

  • [Journal Article] 母集団薬物動態解析の基礎:線形混合効果モデル・非線形混合効果モデルの数理2015

    • Author(s)
      船渡川伊久子,船渡川隆
    • Journal Title

      計量生物学

      Volume: 印刷中

    • NAID

      130005097963

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] 近年の日本における肺癌発生の推移と関連因子2014

    • Author(s)
      船渡川伊久子
    • Journal Title

      健康管理

      Volume: 722 Pages: 19-25

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] 小児・思春期の発育についての疫学的検討2014

    • Author(s)
      船渡川伊久子
    • Journal Title

      思春期学

      Volume: 32 Pages: 145-149

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Trends in smoking and lung cancer mortality in Japan, by birth cohort, 1949-2010.2013

    • Author(s)
      Funatogawa I, Funatogawa T, Yano E
    • Journal Title

      Bulletin of the World Health Organization

      Volume: 91 Issue: 5 Pages: 332-340

    • DOI

      10.2471/blt.12.108092

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The first generation in which many women began smoking. (Letter)2013

    • Author(s)
      Funatogawa I
    • Journal Title

      Lancet

      Volume: 381 Issue: 9876 Pages: 1455-1455

    • DOI

      10.1016/s0140-6736(13)60918-6

    • Related Report
      2013 Research-status Report
  • [Journal Article] Trends in smoking and lung cancer mortality in Japan, by birth cohort, 1949-20102013

    • Author(s)
      Funatogawa I, Funatogawa T, Yano E
    • Journal Title

      Bulletin of the World Health Organization

      Volume: 印刷中

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impacts of early smoking initiation: long-term trends of lung cancer mortality and smoking initiation from repeated cross-sectional surveys in Great Britain2012

    • Author(s)
      Funatogawa I, Funatogawa T, Yano E
    • Journal Title

      BMJ Open

      Volume: 2 Issue: 5 Pages: 1-6

    • DOI

      10.1136/bmjopen-2012-001676

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Smoking statistics in the mid-1920s birth cohorts2014

    • Author(s)
      Ikuko Funatogawa
    • Organizer
      35th annual conference of international society for clinical biostatistics
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2014-08-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Non-monotonic trends in smoking statistics2014

    • Author(s)
      Ikuko Funatogawa
    • Organizer
      35th annual conference of international society for clinical biostatistics
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2014-08-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Statistical issues arising when the interval between initiation of exposure and death is more than half a century2013

    • Author(s)
      Ikuko Funatogawa, Takashi Funatogawa
    • Organizer
      34th annual conference of the International Society for Clinical Biostatistics
    • Place of Presentation
      LMU (Ludwig-Maximilaus-Universitat) (ドイツ、ミュンヘン)
    • Related Report
      2013 Research-status Report
  • [Presentation] 曝露開始から死亡までが超長期の場合の統計学的問題

    • Author(s)
      船渡川伊久子、船渡川隆
    • Organizer
      2013年度日本計量生物学会年会
    • Place of Presentation
      パルセいいざか(福島)
    • Related Report
      2013 Research-status Report
  • [Presentation] 日本の出生コホート別喫煙開始年齢と喫煙率及び肺癌死亡の長期トレンドと統計的問題

    • Author(s)
      船渡川伊久子、船渡川隆
    • Organizer
      第24回日本疫学会学術総会
    • Place of Presentation
      日立システムズホール仙台(仙台)
    • Related Report
      2013 Research-status Report
  • [Presentation] 近年の日本における肺癌発生の推移と関連因子

    • Author(s)
      船渡川伊久子
    • Organizer
      第22回呼吸器疾患フォーラム
    • Place of Presentation
      交通ビル地下ホール(東京)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Statistical approach when time lags between the start of the exposure and death are very long

    • Author(s)
      Ikuko Funatogawa, Takashi Funatogawa
    • Organizer
      Environmental Health Conference 2013
    • Place of Presentation
      Congress Center Basel (バーゼル、スイス)
    • Related Report
      2013 Research-status Report
  • [Presentation] Statistical issues in Smoking and Health

    • Author(s)
      Ikuko Funatogawa
    • Organizer
      5th Asia-Pacific Conference on Public Health
    • Place of Presentation
      Seoul Olympic Parktel (韓国、ソウル)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 英国の出生コホート別喫煙開始年齢と肺癌死亡の長期トレンドに基づく早期喫煙開始のインパクト

    • Author(s)
      船渡川伊久子、船渡川隆、矢野栄二
    • Organizer
      第23回日本疫学会学術総会
    • Place of Presentation
      大阪大学(大阪)
    • Related Report
      2012 Research-status Report
  • [Presentation] 企画セッション:統計学初級中級講座 マルチレベル解析と繰り返し測定データの解析 医学分野を中心とした連続型反応の経時データ解析

    • Author(s)
      船渡川伊久子
    • Organizer
      2012年度統計関連学会連合大会
    • Place of Presentation
      北海道大学(北海道)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 無作為化臨床試験の前値を共変量とした共分散分析で共分散と後値の分散が群間で異なる場合

    • Author(s)
      船渡川隆、船渡川伊久子
    • Organizer
      2012年度統計関連学会連合大会
    • Place of Presentation
      北海道大学(北海道)
    • Related Report
      2012 Research-status Report
  • [Presentation] 反応に基づく投与量変更を行った経時測定データからの尤度を用いた用量反応関係

    • Author(s)
      船渡川伊久子、船渡川隆
    • Organizer
      2012年度統計関連学会連合大会
    • Place of Presentation
      北海道大学(北海道)
    • Related Report
      2012 Research-status Report
  • [Presentation] Analysis of Covariance in Randomized Clinical Trials with Pre- and Post- Treatment Measurements

    • Author(s)
      Takashi Funatogawa, Ikuko Funatogawa
    • Organizer
      XXVIth International Biometric Conference
    • Place of Presentation
      Kobe International Conference Center (神戸)
    • Related Report
      2012 Research-status Report
  • [Presentation] Dose-Response Relationship from Longitudinal Data with Response-Dependent Dose-Modification Using Likelihood Method

    • Author(s)
      Ikuko Funatogawa, Takashi Funatogawa
    • Organizer
      XXVIth International Biometric Conference
    • Place of Presentation
      Kobe International Conference Center (神戸)
    • Related Report
      2012 Research-status Report
  • [Presentation] Likelihood based estimation for an effect of a time-varying covariate

    • Author(s)
      Ikuko Funatogawa, Takashi Funatogawa
    • Organizer
      33rd annual conference of the International Society for Clinical Biostatistics
    • Place of Presentation
      Grieghallen (ノルウェー、ベルゲン)
    • Related Report
      2012 Research-status Report
  • [Book] 経時データ解析2015

    • Author(s)
      船渡川伊久子,船渡川隆
    • Publisher
      朝倉書店
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-31   Modified: 2019-07-29  

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