| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
We have developed a novel algorithm for designing functional RNAs with conformational changes such as artificial riboswitches. By using the method developed in the present study, by virtue of a multi-objective genetic algorithm which was employed in the present study, we can design RNA sequences which not only have multistable structures but also have various specified features such as an energy barrier height and the GC content without empirical weight parameters among the objective functions. We compared the present method with the previous design methods (RNAdesign and Frnakenstein) and found that the present method shows comparable or better design performances compared to the previous methods.
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