• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of the Brain Operating Principles by Analyzing Large Scale Neuron-Astrocyte Networks with Genetic Algorithm

Research Project

Project/Area Number 24500365
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Bioinformatics/Life informatics
Research InstitutionThe Institute of Statistical Mathematics

Principal Investigator

TAMURA Yoshiyasu  統計数理研究所, モデリング研究系, 教授 (60150033)

Co-Investigator(Kenkyū-buntansha) SOMEYA Hiroshi  東海大学, 情報理工学部, 講師 (00333518)
OKU Yoshitaka  兵庫医科大学, 医学部, 教授 (20252512)
OKADA Yasumasa  独立行政法人国立病院機構村山医療センター(臨床研究センター), 電気生理学研究室, 室長 (80160688)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsカルシウムイメージング / アストロサイト
Outline of Final Research Achievements

By calcium imaging, we recorded activities of neurons and astrocytes in the brainstem respiratory center of the rat and mouse, and found a subset of astrocytes of which activities preceded inspiratory neural output. By time series analysis of the imaging data and neural respiratory output and by computer simulation of the rhythm generating neuron-astrocyte networks, we concluded that respiratory rhythm is generated by loosely coupled intrinsically oscillating neurons and astrocytes.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (42 results)

All 2015 2014 2013 2012 Other

All Journal Article (10 results) (of which Peer Reviewed: 8 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (32 results)

  • [Journal Article] Anatomical and functional pathways of rhythmogenic inspiratory premotor information flow originating in the pre-Bötzinger complex in the rat medulla2014

    • Author(s)
      Koshiya N, Oku Y, Yokota S, Oyamada Y, Yasui Y, Okada Y
    • Journal Title

      Neuroscience

      Volume: 268 Pages: 194-211

    • DOI

      10.1016/j.neuroscience.2014.03.002

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Pixel timing correction in time-lapsed calcium imaging using point scanning microscopy2014

    • Author(s)
      Boiroux D, Oke Y, Miwakeichi F, Oku Y
    • Journal Title

      Journal Neuroscience Methods

      Volume: 30, 237 Pages: 60-68

    • DOI

      10.1016/j.jneumeth.2014.08.008

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The hypoxic ventilatory response and TRPA1 antagonism in conscious mice2014

    • Author(s)
      Mieczyslaw Pokorski, Kotaro Takeda, Yutaka Sato and Yasumasa Okada
    • Journal Title

      Acta Physiologica

      Volume: 210 Issue: 4 Pages: 928-938

    • DOI

      10.1111/apha.12202

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 各種病態における呼吸困難感の出現・知覚機序とその対策2013

    • Author(s)
      岡田泰昌、梅田啓
    • Journal Title

      呼吸と循環

      Volume: 61 Pages: 444-454

    • NAID

      40019684654

    • Related Report
      2013 Research-status Report 2012 Research-status Report
  • [Journal Article] COPDの呼吸困難感に対する対策2013

    • Author(s)
      岡田泰昌、武田湖太郎、梅田啓
    • Journal Title

      呼吸器内科

      Volume: 23 Pages: 610-617

    • NAID

      40019753724

    • Related Report
      2013 Research-status Report
  • [Journal Article] Striking a Mean- and Parent-centric Balance in Real-valued Crossover Operators2013

    • Author(s)
      染谷博司
    • Journal Title

      IEEE Transactions on Evolutionary Computation

      Volume: 17 Issue: 6 Pages: 737-754

    • DOI

      10.1109/tevc.2012.2200255

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Standardization of size, shape and internal structure of spinal cord images: comparison of three transformation methods2013

    • Author(s)
      Yasuhisa Fujiki, Shigefumi Yokota, Yasumasa Okada, Yoshitaka Oku, Yoshiyasu Tamura, Makio Ishiguro, Fumikazu Miwakeichi
    • Journal Title

      PLos One

      Volume: 8 Pages: 76415-8

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Preinspiratory calcium rise in putative pre-Botzinger complex astrocytes2012

    • Author(s)
      Okada Y, Sasaki T, Oku Y, Takahashi N, Seki M, Ujita S, Tanaka KF, Matsuki N, Ikegaya Y.
    • Journal Title

      J Physiol

      Volume: 590 Pages: 4933-4944

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 正確さの比較:Bland-Altman解析による呼吸器内科領域代替検査法の検証2012

    • Author(s)
      梅田 啓, 岡田 泰昌
    • Journal Title

      呼吸と循環

      Volume: 60 Pages: 840-848

    • NAID

      40019390146

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 単一試行生体イメージングデータ解析のためのAR型モデルに基づく時空間フィルタリング法2012

    • Author(s)
      三分一 史和、越久 仁敬、岡田 泰昌、川合 成治、田村 義保、石黒 真木夫
    • Journal Title

      統計数理

      Volume: 60 Pages: 149-157

    • NAID

      120006020413

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Astrocytes mediate short-term plasticity of breathing2015

    • Author(s)
      Okada Y, Takeda K, Someya H, Oku Y, Miwakeichi F, Ishiguro M, Tamura Y, Pokorski M.
    • Organizer
      Experimental Biology 2015
    • Place of Presentation
      Boston, USA
    • Year and Date
      2015-03-28 – 2015-04-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] Anatomy of the respiratory rhythmogenic kernel: preBotzinger complex of the medulla. In Symposium “延髄脊髄呼吸調節機構: 形態と機能の統合的理解”2015

    • Author(s)
      Okada Y, Yokota S
    • Organizer
      第120回日本解剖学会総会・全国学術集会 第92回日本生理学会大会 合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] アストロサイト活性化阻害は高度低酸素による換気と脳波信号の抑制を増強する(Blockade of astrocytic activation augments hypoxia-induced depression of ventilation and EEG)2015

    • Author(s)
      福士勇人、武田湖太郎、長谷部洋平、堀内城、岡田泰昌
    • Organizer
      第120回日本解剖学会総会・全国学術集会 第92回日本生理学会大会 合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Loose regularities of calcium bursting sequence among inspiratory cells in the pre-Botzinger complex during rhythmic burst.(Pre-Botzinger complex領域における自発的同期活動時の呼吸性細胞の活性化順序の緩やかな規則性)2015

    • Author(s)
      Oke Y, Bouiroux D, Miwakeichi F, Oku Y
    • Organizer
      第92回日本生理学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Connectomics of the inspiratory center: Anatomical tract and propagation dynamics from the preBotzinger complex2014

    • Author(s)
      Okada Y, Oku Y, Yokota S, Oyamada Y, Yasui Y, Koshiya N
    • Organizer
      Society for Neuroscience Meeting 2014 (Neuroscience2014)
    • Place of Presentation
      Washington DC
    • Year and Date
      2014-12-15 – 2014-12-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Effect of Incomplete Smoking Cessation with Varenicline or Nicotine Patch on Vascular Endothelial Function as Assessed by Flow-Mediated Vasodilation2014

    • Author(s)
      Umeda A, Kato T, Mochizuki T, Watanabe T, Yamane T, Miyagawa K, Takeda H, Okada Y
    • Organizer
      9th Congress of the Asian Pacific Society of Respirology (APSR 2014)
    • Place of Presentation
      Bali, Indonesia
    • Year and Date
      2014-11-13 – 2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Connectivity of the respiratory network by using Granger causality2014

    • Author(s)
      Boiroux D, Oke Y, Miwakeichi F, Oku Y
    • Organizer
      XIIIth Oxford Breathing Meeting
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2014-10-27 – 2014-10-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Flexible bursting sequence among inspiratory cells in the pre-Botzinger complex revealed by wide-field Ca2+ imaging2014

    • Author(s)
      Oke Y, Bouiroux D, Miwakeichi F, Oku Y
    • Organizer
      XIIIth Oxford Breathing Meeting
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2014-10-27 – 2014-10-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Potentially false positive detection of respiratory rhythmic astrocytic activity in the Pre-Botzinger Complex2014

    • Author(s)
      Oku Y, Miwakeichi F, Hülsmann S
    • Organizer
      XIIIth Oxford Breathing Meeting
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2014-10-27 – 2014-10-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] From chaotic recruitment of the pre-Botzinger complex (pre-BotC) to functional connectomics of inter-pre-BotC tract and pan-network premotor pathways2014

    • Author(s)
      Koshiya N, Oku Y, Okada Y, Smith JC
    • Organizer
      The XIIIth Oxford Breathing Meeting, Respiratory and Cardiovascular
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2014-10-26 – 2014-10-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Active roles of meduIlary astrocytes in respiratory rhythm generation and plasticity2014

    • Author(s)
      Okada Y
    • Organizer
      The XIIIth Oxford Breathing Meeting, Respiratory and Cardiovascular
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2014-10-26 – 2014-10-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Significance of astrocytic activation in hypoxic responses of ventilation and higher brain function2014

    • Author(s)
      Fukushi I, Takeda K, Hasebe Y, Horiuchi J, Okada Y
    • Organizer
      The XIIIth Oxford Breathing Meeting, Respiratory and Cardiovascular
    • Place of Presentation
      Sydney, Australia
    • Year and Date
      2014-10-26 – 2014-10-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] Network Connectivity of the Respiratory Rhythm-generating Kernel2014

    • Author(s)
      Oku Y, Lal A, Oke Y, Boiroux D
    • Organizer
      24th Annual Conference of Japanese Neural Network Society(日本神経回路学会第24回全国大会)
    • Place of Presentation
      函館
    • Year and Date
      2014-08-27 – 2014-08-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 中等度および高度低酸素、高酸素、高二酸化炭素に対する換気応答におけるTRPA1チャネルの意義2014

    • Author(s)
      岡田泰昌、武田湖太郎、Mieczyslaw Pokorski
    • Organizer
      平成26年度生理学研究所研究会『TRPチャネル研究を通じて見えてきた新たな生理学への光』
    • Place of Presentation
      岡崎
    • Year and Date
      2014-06-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Prevalence of diabetes and impaired glucose tolerance in patients with sleep apnea syndrome2014

    • Author(s)
      Umeda A, Yamane T, Ieieri T, Miyashita Y, Sato A, Ueda R, Takeuchi J, Iwamoto T, Yonemaru M, Okada Y
    • Organizer
      The 54th Annual Meeting of the Japanese Respiratory Society (第54回日本呼吸器学会学術講演会)
    • Place of Presentation
      大阪
    • Year and Date
      2014-04-25 – 2014-04-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Dose-dependent suppression of respiration by systemically administered DMSO.2014

    • Author(s)
      Fukushi I, Takeda K, Pokorski M, Oyamada Y, Okada Y
    • Organizer
      The 54th Annual Meeting of the Japanese Respiratory Society (第54回日本呼吸器学会学術講演会)
    • Place of Presentation
      大阪
    • Year and Date
      2014-04-25 – 2014-04-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Pokorski M. Post-hypoxic potentiation of breathing is induced by sustained activation of astrocytes.2014

    • Author(s)
      Okada Y, Fukushi I, Takeda K, Oyamada Y, Oku Y, Miwakeichi F, Someya H, Ishiguro M, Tamura Y
    • Organizer
      The 54th Annual Meeting of the Japanese Respiratory Society (第54回日本呼吸器学会学術講演会)
    • Place of Presentation
      大阪
    • Year and Date
      2014-04-25 – 2014-04-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 呼吸中枢の解剖・生理・病態生理 (Respiratory Center: Anatomy, Physiology and Pathophysiology).2014

    • Author(s)
      岡田泰昌
    • Organizer
      第54回日本呼吸器学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2014-04-25 – 2014-04-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Severe hypoxia-induced ventilatory depression analyzed by spectrography of EEG and respiratory output2014

    • Author(s)
      Fukushi I, Kuniya M, Maeno Y, Muraoka Y, Takeda K, Okada Y.
    • Organizer
      The 91st Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Research-status Report
  • [Presentation] Effects of systemic administration of TRPA1 channel antagonist on nociceptive and respiratory control systems2013

    • Author(s)
      Okada Y, Takeda K, Oyamada Y, M. Pokorski
    • Organizer
      The 36th Annual Meeting of the Japan Neuroscience Society(Neuro2013)
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Research-status Report
  • [Presentation] DMSO:A potential detriment for nociception and respiration.2013

    • Author(s)
      Takeda K, Pokorski M, Oyamada Y, Okada Y.
    • Organizer
      The 36th Annual Meeting of the Japan Neuroscience Society (Neuro2013),
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Research-status Report
  • [Presentation] Effects of TRPA1 channel antagonism on hypoxic and hypercapnic ventilatory responses2013

    • Author(s)
      Takeda K, Pokorski M, Sato Y, Oyamada Y, Okada Y.
    • Organizer
      The 43rd annual meeting of the Society for Neuroscience (Neuroscience2013)
    • Place of Presentation
      San Diego
    • Related Report
      2013 Research-status Report
  • [Presentation] 人為的なコドン再定義から考える遺伝暗号の進化2013

    • Author(s)
      坂本 健作、向井 崇人、大竹 和正、染谷 博司
    • Organizer
      第15回日本RNA学会
    • Place of Presentation
      愛媛
    • Related Report
      2013 Research-status Report
  • [Presentation] Respiratory rhythm is driven by astrocytes in the preBotzinger complex2013

    • Author(s)
      Okada Y
    • Organizer
      The 90th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Effects of DMSO on nociception and respiratory control2013

    • Author(s)
      Takeda K, Pokorski M, Oyamada Y, Okada Y
    • Organizer
      The 90th Annual Meeting of the Physiological Society of Japan
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Post-hypoxic potentiation of breathing is mediated by astrocytes2013

    • Author(s)
      Okada Y, Takeda K, Oyamada Y, Oku Y, Miwakeichi F, Someya H, Ishiguro M, Tamura Y, Pokorski M
    • Organizer
      The XI European Meeting on Glial Cells in Health and Disease
    • Place of Presentation
      Berlin
    • Related Report
      2012 Research-status Report
  • [Presentation] Sensory information processing by astrocytes and neurons in the spinal cord dorsal horn via P2X receptors: voltage-imaging, patch clamp and anatomical analyses2012

    • Author(s)
      Okada Y, Aoyama R, Yokota S, Yasui Y, Fukuda K, Shinozaki Y, Yoshida H, Nakamura M, Chiba K, Yasui Y, Kato F, Toyama Y.
    • Organizer
      Purine 2012
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] Anatomical identification of intrinsically chemosensitive astrocytes and neurons in the ventral medulla2012

    • Author(s)
      Okada Y, Yokota S, Oku Y
    • Organizer
      FENS Forum 2012
    • Place of Presentation
      Barcelona
    • Related Report
      2012 Research-status Report
  • [Presentation] P2X receptor-mediated nociceptive information processing by astrocytes and neurons in the dorsal horn: voltage imaging, patch clamp recording and immunostaining analyses.2012

    • Author(s)
      Okada Y, Aoyama R, Yokota S, Yasui Y, Fukuda Y, Shinozaki Y, Yoshida H, Nakamura M, Chiba K, Yasui Y, Kato F, Toyama Y
    • Organizer
      A satellite event of the FENS Forum 2012
    • Place of Presentation
      Barcelona
    • Related Report
      2012 Research-status Report
  • [Presentation] Spatial averaging of dynamic voltage imaging data by standardizing the shape, size and internal structure of multiple samples2012

    • Author(s)
      Fujiki Y, Okada Y, Oku Y, Yokota S, Tamura Y, Ishiguro M, Miwakeichi F.
    • Organizer
      35th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] 生体イメージングデータ解析のための時空間フィルタリング法.2012

    • Author(s)
      三分一 史和,越久 仁敬,岡田 泰昌,川合 成治,田村 義保,石黒 真木夫
    • Organizer
      第17回認知神経科学会学術集会、シンポジウムII「機能画像と高次脳機能」
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Post-hypoxic potentiation of breathing is mediated by astrocytes,

    • Author(s)
      Okada Y, Takeda K, Oyamada Y, Oku Y, Miwakeichi F, Someya. H, Ishiguro M, Tamura Y, Mieczyslaw. P.
    • Organizer
      XI European Meeting on Glial Cells in Health and Disease
    • Place of Presentation
      Berlin
    • Related Report
      2013 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi