Dopamine-depedent activity transition in the indirect pathway of basal ganglia
| Project/Area Number |
24500372
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | パーキンソン病 / 大脳基底核 / 視床下核 / 淡蒼球 / 数理モデル / 神経回路モデル / ドーパミン |
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| Outline of Final Research Achievements |
In patients of Parkinson's disease, one of representative motor disorders, an abnormal pattern of neural activity are frequently observed, which has been thought to have a close relationship to disordered movements. The abnormal activities are known to be caused by dopamine depletion in the brain, but the detailed mechanism is poorly understood. In the present study, we constructed a mathematical model of the related neural circuit in the indirect pathway of basal ganglia and examined what could be the conditions to cause the abnormal activities in the neural circuit. We found that one of them was specific connection patterns within the neural circuit and the other one is that extraordinarily increased inhibitory inputs from the external segment of globus pallidus to subthalamic induced by dopamine depletion .
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Report
(4 results)
Research Products
(7 results)
