| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
We have previously demonstrated that VEGF-mediated enhancement of adult neurogenesis leads to alteration in affective behaviors including antidepressant-/anxiolytic-like effect and reduction of aggressive behaviors in mice. In this study, we used a drug-inducible gene expression system to artificially facilitate cell division of neural stem cells in mice. We found that administration of the inducer enhanced adult neurogenesis in subgranular zone in the hippocampus. Neurogenesis was particularly active around capillaries. Mice were tested in several behavioral paradigms. We found that facilitation of neurogenesis for 3 weeks was not sufficient to improve spatial memory. In contrast, anxiolytic-like behavior was observed in mice, implying that affective behavior may be more susceptible to enhancement of adult neurogenesis.
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