Analyses of learning and affective behaviors through induction of adult neurogenesis and
| Project/Area Number |
24500383
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Kyushu University |
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Principal Investigator |
Udo Hiroshi 九州大学, 理学(系)研究科(研究院), 助教 (70363322)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 神経新生 / 脳機能 / 学習・記憶 / 情動 / マウス / 神経 / 海馬 / 行動 / 細胞 / 記憶 |
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| Outline of Final Research Achievements |
We have previously demonstrated that VEGF-mediated enhancement of adult neurogenesis leads to alteration in affective behaviors including antidepressant-/anxiolytic-like effect and reduction of aggressive behaviors in mice. In this study, we used a drug-inducible gene expression system to artificially facilitate cell division of neural stem cells in mice. We found that administration of the inducer enhanced adult neurogenesis in subgranular zone in the hippocampus. Neurogenesis was particularly active around capillaries. Mice were tested in several behavioral paradigms. We found that facilitation of neurogenesis for 3 weeks was not sufficient to improve spatial memory. In contrast, anxiolytic-like behavior was observed in mice, implying that affective behavior may be more susceptible to enhancement of adult neurogenesis.
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Report
(4 results)
Research Products
(8 results)
