| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
Olfactory bulb (OB) interneurons, such as periglomerular cells and granule cells, are generated in the subventricular zone of lateral ventricle and integrated into the pre-existing neural circuit throughout the life. However, it remains unknown how the interneurons migrate and are integrated into the pre-existing neural circuit within the OB.
To study the migration process of interneurons in the OB, we performed the time-lapse imaging of slice cultures. Although it was previously reported that blood vessels act as a scaffold for the interneurons, we found that some interneurons moved along blood vessels, but others utilized another interneuron as a scaffold to migrate radially within the OB. These results suggest that cell-cell interactions between interneurons play an important role of the neuronal migration in the OB.
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